Study (observational) | Clearly focused question | Recruited subjects in an acceptable way | Exposure accurately measured to minimize bias | Outcome accurately measured to minimize bias | Identified all important confounding factors | Account of the confounding factors in design and/or analysis? | Was the follow up of subjects complete enough? | Was the follow up of subjects long enough? | Do you believe the results? | Can the results be applied to the local population? | Do the results fit with other available evidence? | Implications of this study for practice? |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Clark et al. [14] | Yes | Yes | Yes | Yes | Yes | Yes | n/a | n/a | Yes | Can’t tell | Yes | Can’t tell |
Shinohara et al. [15] | Yes | Yes | Yes | Yes | Yes | Yes | n/a | n/a | Yes | Can’t tell | Yes | Can’t tell |
Ficarra et al. [16] | Yes | Yes | Yes | Yes | Yes | Yes | n/a | n/a | Yes | Can’t tell | Yes | Can’t tell |
Onishi et al. [17] | Yes | Yes | Yes | Yes | Yes | No | Can’t tell | Yes | Yes | Can’t tell | Yes | Can’t tell |
Wang et al. [18] | Yes | Yes | Yes | Yes | Yes | Yes | n/a | n/a | Yes | Yes | Yes | Yes |
Sandbergen et al. [19] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Watanabe et al. [21] | Yes | Yes | Yes | Yes | Yes | Can’t tell | Yes | Yes | Yes | Can’t tell | Yes | Yes |
Study (RCT) | Clearly focused question | Randomization to intervention | All patients entering study accounted for | A: Patients “blinded” B: Investigators “blinded” C: “People assessing blinded” | Study groups similar at baseline | Did intervention and control group receive same level of care? | Effects of intervention reported comprehensively | Precision of estimate of treatment effect reported | Benefits of intervention outweigh the harms and costs | Can the results be applied to the local population? | Would the intervention provide greater value to the patients in your care that any of the existing interventions? | |
Breau et al. [20] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |