Table 2 Effects of disulfiram on tumor inhibition rates from animal studies
From: Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
Information of reference | Information of animals | Intervention and tumor inhibition rate | Toxicity evaluation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reference | Country | Tumor | Strain and gender | Old (weeks) | Weight (g) | Animal tumor model | Intervention methods | Negative control | Positive control | Treatment group | Inhibit Rate | Parameter | Outcome |
Peng et al. | China | Lung cancer | Female Balb/C nude mice | 4−5 | 18−22 | 1.0 × 106 A549 cells, SC, right flank | Every 4 days with 4 times, iv | Saline | _ | DSF 10 mg/kg + copper 1.5 mg/kg ig PNpL-DSF/Cu(II)/DDC (1:1, 1mg/kg) | TSR% = 16.6% TSR% = 51.6% | No significant weight loss | Low |
Parikshit et al. | China | Breast cancer | Female Balb/C nude mice | 4−5 | 18 ± 2 | 1.0 × 105 4T1 cells, SC, left armpit | Every 3 days with 6 times, iv | Saline | _ | DSF 15 mg/kg DSF-NLC 15 mg/kg TPGS-DSF-NLC 15 mg/kg | TGI% = 8.49%. TGI% = 29.2% TGI% = 48.24% | No noticeable body weight loss | Safety |
Ji et al. | China | Breast cancer | Female Balb/C nude mice | _ | 20 ± 2 | 8.0 × 105 4T1 cells, SC, right flank | Everyday with 2 weeks, iv or every day with 2 weeks, ig | Saline | PTX (8mg/kg) TSR% = 55.01% | DSF 20 mg/kg ig DSF-NSps 20 mg/kg ig DSF-NSps 20 mg/kg iv DSF-NSps 10 mg/kg iv DSF-NSps 5 mg/kg, iv | TSR% = 0% TSR% = 59.03% TSR% = 80% TSR% = 75.86% TSR% = 69.21% | Weight increased slightly | _ |
Zhou et al. | China | Liver cancer | KunMing mice | 5–6 | _ | 1.5 × 107 H-22 cells, SC, left axilla | Every 3 days with 4 times, iv | Saline | 5-FU (20 mg/kg ) TIR% = 47.4% | DSF NPs 3 mg/mL DSF NPs 40 mg/kg + Cu(OI)2-S 0.3 mg/kg DSF NPs 40 mg/kg + Cu(OI)2-L 0.3 mg/kg | TIR% = 26.8% TIR% = 35.5% TIR% = 50.3% | _ | _ |
Tao et al. | China | Breast cancer | Female Balb/C nude mice | _ | 20 ± 2 | 3.0 × 106 4T1 cells, SC, right flank | Every 2 days with 4 times, iv | Saline | DOX (5 mg/kg ) TIR% = 68.27% | DSF 5 mg/kg DOX 5 mg/kg +DSF 5 mg/kg Co-NPs (DOX 5 mg/kg + DSF 5 mg/kg) | TIR% = 34.81% TIR% = 80.92% TIR% = 89.27% | No significant difference in body weight change | Safety |
Song et al. | China | Lung cancer | Female Balb/C nude mice | 6 | 20.0 | 2.0 × 106 A549DDP cells, SC, right flank | Every 2 days with 4 times, iv | Saline | _ | PGA-CisPt 5.0 mg/kg PGA-CisPt 5.0 mg/kg+ NPs-DSF 10.mg/kg | TSR% = 45.6% TSR% = 75.4% | No body weight changes | Safety |
Hamidreza et al. | Iran | Breast cancer | Female Balb/C nude mice | 5 | _ | 1.0 × 106 4T1 cells, mammary fat pad | 2 weeks, iv | Blank NPs | _ | DFS 10 mg/kg DS-P-NPs 10 mg/kg DS-PPF-NPs 10 mg/kg | TSR% = 17.07% TSR% = 66.67% TSR% = 75% | DS-P-NPs, DS-PPF-NPs groups more reduction weight than the DSF | No sign |
Song et al. | China | Breast cancer | Balb/C mice | 5-6 | _ | 2.0 × 106 4T1 cells, SC, right flank | Every 2 days with 6 times, iv | Saline | _ | DSF 15 mg/kg NP4/5/1 15 mg/kg | TSR% = 0 TSR% = 43.2% | No obvious body weight loss | Safety |
Jennifer et al. | USA | Breast tumor | Female SCID mice | _ | _ | 1.0 × 106 SUM149 cells, SC, flank | Daily, iv | Vehicle | _ | DSF 50 mg/kg DSF 50 mg/kg + Cu 0.5 mg/kg | TIR% = 75% TIR% = 84% | No noticeable body weight change | _ |
Choi et al. | Korea | Atypical teratoid/rhabdoid tumors | Female Balb/C nude mice | 7 | _ | 1.0 ×104 AT/RT cells, SC, _ | Every 5 consecutive days with 3 weeks, ip | DMSO | _ | DSF 100 mg/kg | TSR% = 72.25% | _ | No major |
Vino et al. | China | Malignant Pleural Mesothelioma | Female Balb/C nude mice | 5 | _ | 0.5 × 106 AB12 cells, SC, right flanks | Daily with 17 days, ip | Vehicle | _ | DSF/Cu 50 mg/kg | TSR% = 71.5% | Weight of DSF-Cu group was 75% lower than that of vehicle group | _ |