Table 1 Review inclusion and exclusion criteria

Participants

Patients diagnosed with subclinical hypothyroidism, no demographic or etiological restrictions

Pregnant women

Children and adolescents

Diagnosis of overt hypothyroidism

Intervention

Management of SCH, i.e. treatment using levothyroxine or follow-up without treatment

No reported treatment status

Comparator

No restriction on comparison or control groups

Outcomes

Cardiovascular outcomes

Cerebrovascular outcomes

Quality of life measures

Frailty fractures

All-cause mortality

Other reported outcomes (secondary)

No reporting of any of the primary outcomes of interest

Study design

Quantitative systematic reviews and meta-analyses of empirical research

Any other study types (e.g. narrative reviews, scoping reviews, qualitative syntheses)

Review characteristics

Articles in any language

Any period of study or date of publication