Table 3 Subgroup analyses by impact of RT-PCR based assays on lower- and middle-income countries (LMICs) versus upper middle-income countries (UMICs). We will assess sources of data to these graders
Test property | Summary of measure test accuracya (95%) | Test of heterogeneity | ||
|---|---|---|---|---|
Lower-MICs (n = 8; b 2047) AUC = 0.99 |  | χ2 (d.f. = 7) | l2 | p value |
Sensitivity | 65 (58–72) | 44.28 | 84.20 | < 0.001 |
Specificity | 99 (99–99 | 10.46 | 33.10 | 0.1639 |
Positive likelihood ratio (PLR) | 86.61 (46.72–160.53) | 5.97 | 0.0 | 0.5432 |
Negative likelihood ratio (NLR) | 0.367 0.233–0.578 | 29.54 | 76.30 | < 0.001 |
Diagnostic odd ratio (DOR) | 311.43 (106.76–908.51) | 11.25 | 37.8 | 0.1280 |
Upper-MICs (n = 12; b 3487) AUC = 0.99 |  | χ2 (d.f. = 11) | l2 | p value |
Sensitivity | 68 (63–73) | 197.71 | 94.40 | < 0.001 |
Specificity | 97 (96–98) | 291.40 | 96.20 | < 0.001 |
Positive likelihood ratio (PLR) | 80.90 (10.31–634.9) | 247.81 | 95.6 | < 0.001 |
Negative likelihood ratio (NLR) | 0.20 (0.09–0.42) | 228.53 | 95.2 | < 0.001 |
Diagnostic odd ratio (DOR) | 522.72 (107.04–2552.8) | 50.80 | 78.30 | < 0.001 |