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Table 4 Design features used for assessment of risk of bias

From: Systematic reviews of observational studies of Risk of Thrombosis and Bleeding in General and Gynecologic Surgery (ROTBIGGS): introduction and methodology

Domaina

Low risk of bias

High risk of bias

Sampling

Consecutive patient recruitment or administrative database with random sampling

Non-consecutive patient recruitment or administrative database with non-random sampling

Thromboprophylaxis documentation

Reporting of patients’ thromboprophylaxis

No reporting of patients’ thromboprophylaxis

Source of information

Prospective data collection by study investigators

Retrospective duplicate chart reviews with good documentation of agreement between reviewers

Retrospective duplicate chart reviews without documentation of agreement between reviewers

Administrative database information

Recruitment years

Studies with the majority of patient recruitment years 2010 or after

Studies with the majority of patient recruitment years 2009 or before

Specification of length of follow-up

Studies that clearly define the time period of follow-up (up to 3 months)

Studies that do not clearly define the time period of follow-up

Study type

International multicenter; Multicenter in one country; Single center, not single surgeon

Single surgeon series

Overall risk of biasa

No high risk of bias domains: Very low risk of bias

One high risk of bias domain: Low risk of bias

Two high risk of bias domains: Moderate risk of bias

Three or more high risk of bias domains: High risk of bias

  1. aWe will use the overall risk of bias as eligibility criteria when there are a sufficient number of patients in studies with low risk of bias for a given procedure