QUADAS2 tool domain | RoB based on number of studies | RoB based on sample size | RoB based on effective sample size | ||||||
---|---|---|---|---|---|---|---|---|---|
Risk of bias | Low | Unclear | High | Low | Unclear | High | Low | Unclear | High |
Patient selection | 41% | 31% | 28% | 60% | 22% | 18% | 61% | 22% | 17% |
Index test | 0% | 41% | 59% | 0% | 54% | 46% | 0% | 53% | 47% |
Reference standard | 78% | 82% | 0% | 85% | 15% | 0% | 85% | 15% | 0% |
Flow and timing | 81% | 13% | 6% | 85% | 7% | 8% | 85% | 7% | 9% |