QUADAS2 tool domain | RoB based on number of studies | RoB based on sample size | RoB based on effective sample size | ||||||
---|---|---|---|---|---|---|---|---|---|
Risk of bias | Low | Unclear | High | Low | Unclear | High | Low | Unclear | High |
Patient selection | 46% | 23% | 31% | 92% | 4% | 4% | 92% | 4% | 4% |
Index test | 38% | 46% | 15% | 16% | 81% | 3% | 13% | 84% | 3% |
Reference standard | 77% | 23% | 0% | 25% | 75% | 0% | 22% | 78% | 0% |
Flow and timing | 62% | 15% | 23% | 95% | 2% | 3% | 95% | 2% | 3% |