Fig. 4

a Summary ROC for MID and NID to detect hypoglycaemia (SROC curve, solid curve; study data, circles; summary estimate, triangle; 95% confidence region, contour ellipsoid; venous blood as the reference standard, grey; capillary blood as the reference standard, black). Pooled sensitivity was significantly higher in trials using venous blood as the reference standard, whereas the influence on pooled specificity was not significant. b Summary receiver operating characteristic (SROC) curve for overall diagnostic accuracy to detect hypoglycaemia of MID and NID. SROC, solid curve; study data, circles; summary estimate, triangle; 95% confidence region, contour ellipsoid; high number of participants (> 50), black; low number of participants (≤50), grey. The pooled sensitivity was significantly higher in studies investigating a larger study cohort