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Table 1 Summary of the findings of the 18 eligible articles on CA 15-3 determination from thawed human biosamples

From: The impact of different preanalytical methods related to CA 15-3 determination in frozen human blood samples: a systematic review

  No. of studies [reference]
Study type
 Retrospective study 17 [22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38]
 Prospective study 1 [39]
Biospecimen type
 Serum 14 [22,23,24,25,26,27,28,29,30,31,32, 34, 35, 39]
 Plasma 1 [33]
 Serum and plasma 1 [36]
 Serum and pleural effusion 1[37]
 Serum and saliva 1 [38]
Storage temperature (°C)
 − 80 9 [26,27,28,29,30, 32, 34, 35, 38]
 − 20 6 [22,23,24,25, 37, 39]
 − 70 1 [31]
 − 85 1 [33]
 − 20; − 70 1 [36]
Patient status/disease
 Breast cancer 14 [22,23,24,25,26,27,28,29, 31,32,33,34,35, 38]
 Pleural effusion 1 [37]
 Adnexal masses and ovarian cancer 1 [30]
 Pregnancy 1 [39]
 Multiple disease 1 [36]
Measurement unit
 U/mL 15 [22,23,24,25,26,27,28,29,30, 32,33,34, 36, 38, 39]
 ng/mL 2 [35, 37]
 U/L 1 [31]
Kit or instrument
 CLEIA 4 [27, 28, 34, 35]
 EIA 3 [25, 29, 39]
 ELISA 3 [22, 37, 38]
 HumaReader Plus made by HUMAN GmbH 2 [23, 24]
 MEIA 2 [30, 31]
 RIA 2 [26, 32]
 CMIA 1 [33])
 Vista vs Advia Centaur 1 [36]