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Table 4 Correlation analysis of lesion recurrence or progression with clinical and therapeutic factors

From: Diagnosis and treatment of Rosai-Dorfman disease of the spine: a systematic literature review

Clinical and therapeutic factors* Recurrence and/or progression of spinal lesions
Yes No p value
Age (n = 54) 36.2 ± 21.8 34.1 ± 18.5 0.758
Focal lesion conditions (n = 51)
 Focally constrained 5(11.4%) 39(88.6%) 0.033#
 Focally concurrent 3(42.9%) 4(57.1%)  
Involved organs (n = 33)
 Single 1(6.7%) 14(93.3%) 0.346
 Multiple 4(22.2%) 14(77.8%)
Treatment options (n = 54)
 Surgery 8(17.8%) 37(82.2%) 0.754
 Non-surgery 2(22.2%) 7(77.8%)  
Surgical strategies (n = 45)
 Total resection 2(9.1%) 20(90.9%) 0.243
 Non-total resection 6(26.1%) 17(73.9%)
Non-surgery therapies (n = 54)
 Yes 4(28.6%) 10(71.4%) 0.261
 No 6(15.0%) 34(85.0%)
  1. Non-surgery therapies include radiotherapy, steroids and/or chemotherapy. Focally constrained lesions mean isolated lesions focally constrained to the dura, intrabony region, or intramedullary region. Focally concurrent lesions mean lesions invading multiple spinal components
  2. *Only data documented in the original literature were included
  3. #Statistically significant at p < 0.05, two-tailed Pearson’s chi-squared test