Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

Table 1 Classification systems (adapted from the 2013 CTFPHC guideline review and other sources) [26,27,28,29]

Cytology			Histology
Dysplasia	Bethesda	BSCC	CIN	SIL
Atypia	ASCUS	Borderline change in squamous cells	Atypia
Atypia	ASCUS	Borderline change in endocervical cells	Atypia
HPV effect	LSIL	Low-grade dyskaryosis	HPV effect	LSIL
Mild dysplasia	LSIL	Low-grade dyskaryosis	CIN 1	LSIL
Moderate dysplasia	HSIL	High-grade dyskaryosis (moderate)	CIN 2	HSIL
Severe dysplasia		High-grade dyskaryosis (severe)	CIN 3
Carcinoma in situ		High-grade dyskaryosis/?invasive squamous carcinoma
Cancer	Cancer	?Glandular neoplasia of endocervical type	Cancer	AIS
Cancer	Cancer	?Glandular neoplasia (non-cervical)	Cancer	AIS

AIS adenocarcinoma in situ, ASCUS atypical squamous cells of undetermined significance, BSCC British Society for Clinical Cytology, CIN cervical intraepithelial neoplasia, HSIL high-grade squamous intraepithelial lesion (also used for histological diagnoses CIN 2, CIN 3, and carcinoma in situ), LSIL low-grade squamous intraepithelial lesion, SIL squamous intraepithelial lesion

ISSN: 2046-4053