Table 1 Table of PICO

Population

This review will focus on adults with type-2 diabetes mellitus. Studies reporting on adult T2DM patients aged more than 18 years old will be included. Intervention including mixed population age will be included only if the data can be separated. There will be no restriction on the severity of T2DM of subjects in the study.

Intervention

Any intervention or program utilizing self-administered meal replacements will be considered. A meal replacement is defined as prepackaged food products, drinks, or meals that are designed to replace one or more meals and provide a defined amount of energy [20].

Comparator

No comparator is required for this review.

Outcome

Any studies that report the outcome related to the health status of the T2DM subject, including glycemic control, weight reduction, or side effects.