Fig. 2

Summary of risk of bias judgments (low, probably low, probably high, high) using the OHAT framework for the human studies included in our case series. The justification for risk of bias designations for individual studies are provided in Tables S3-S17. Kappa value was 56% (95% confidence interval 44-66%). Note: Double plus sign indicates low, single plus sign indicates probably low, single minus sign indicates probably high, double minus sign indicates high study quality