Table 4 Key points

• The included evidence-based clinical practice guidelines (EB-CPGs) showed significant heterogeneity both of evidence and recommendation grading systems; GRADE was the most commonly used.

• About half of the included EB-CPGs were updated in the last 5 years, and one third of them were rated as strongly recommended based in their high AGREE-II performance.

• They were generally deficient in applicability and in providing monitoring tools.

• We summarized 31 risk stratification and 16 therapeutic/preventive recommendations.

• We found 93 strong for and 46 strong against recommendations, all of which were ready to be considered to be implemented or to be interrupted, respectively.

• The level of evidence and strength of recommendation was higher for therapeutic/preventive recommendation than for risk stratification ones.

• We only found 12/53 (55%) strong risk stratification recommendations based on high/moderate level of evidence and 43/78 (55%) for therapeutic/preventive care recommendations.