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Table 2 Key questions for the evidence summary and relationship to UK NSC screening criteria

From: Case report: a rapid review approach used by the UK National Screening Committee to inform recommendations on general population screening for vasa praevia

AreaUK NSC criteriaQuestion(s)
The condition1. The condition should be an important health problem as judged by its frequency and/or severity. The epidemiology, incidence, prevalence and natural history of the condition should be understood, including development from latent to declared disease, and/or there should be robust evidence about the association between the risk or disease marker and serious or treatable diseaseWhat is the incidence of VP in the UK? If possible, data to be stratified by presence or absence of risk factors
What percentage of VP cases identified in the second trimester will resolve by late pregnancy?
What is the risk of adverse perinatal outcomes in pregnancies associated with VP?
What is the incidence of VCI in the UK? If possible, data to be stratified by presence or absence of risk factors
What is the risk of adverse perinatal outcomes in pregnancies associated with VCI?
The test4. There should be a simple, safe, precise and validated screening testHow effective is second-trimester transabdominal sonography for detecting VP?
How effective is second-trimester transabdominal sonography for detecting VCI?
The intervention9. There should be an effective intervention for patients identified through screening, with evidence that intervention at a presymptomatic phase leads to better outcomes for the screened individual compared with usual care
10. There should be agreed evidence-based policies covering which individuals should be offered interventions and the appropriate intervention to be offered
What is the most effective management pathway for women with screen-detected VP?
What is the most effective management pathway for women with screen-detected VCI?