UK NSC criteria
1. The condition should be an important health problem as judged by its frequency and/or severity. The epidemiology, incidence, prevalence and natural history of the condition should be understood, including development from latent to declared disease, and/or there should be robust evidence about the association between the risk or disease marker and serious or treatable disease
What is the incidence of VP in the UK? If possible, data to be stratified by presence or absence of risk factors
What percentage of VP cases identified in the second trimester will resolve by late pregnancy?
What is the risk of adverse perinatal outcomes in pregnancies associated with VP?
What is the incidence of VCI in the UK? If possible, data to be stratified by presence or absence of risk factors
What is the risk of adverse perinatal outcomes in pregnancies associated with VCI?
4. There should be a simple, safe, precise and validated screening test
How effective is second-trimester transabdominal sonography for detecting VP?
How effective is second-trimester transabdominal sonography for detecting VCI?
9. There should be an effective intervention for patients identified through screening, with evidence that intervention at a presymptomatic phase leads to better outcomes for the screened individual compared with usual care
10. There should be agreed evidence-based policies covering which individuals should be offered interventions and the appropriate intervention to be offered
What is the most effective management pathway for women with screen-detected VP?
What is the most effective management pathway for women with screen-detected VCI?