Table 2 Key questions for the evidence summary and relationship to UK NSC screening criteria
Area | UK NSC criteria | Question(s) |
|---|---|---|
The condition | 1. The condition should be an important health problem as judged by its frequency and/or severity. The epidemiology, incidence, prevalence and natural history of the condition should be understood, including development from latent to declared disease, and/or there should be robust evidence about the association between the risk or disease marker and serious or treatable disease | What is the incidence of VP in the UK? If possible, data to be stratified by presence or absence of risk factors |
What percentage of VP cases identified in the second trimester will resolve by late pregnancy? | ||
What is the risk of adverse perinatal outcomes in pregnancies associated with VP? | ||
What is the incidence of VCI in the UK? If possible, data to be stratified by presence or absence of risk factors | ||
What is the risk of adverse perinatal outcomes in pregnancies associated with VCI? | ||
The test | 4. There should be a simple, safe, precise and validated screening test | How effective is second-trimester transabdominal sonography for detecting VP? |
How effective is second-trimester transabdominal sonography for detecting VCI? | ||
The intervention | 9. There should be an effective intervention for patients identified through screening, with evidence that intervention at a presymptomatic phase leads to better outcomes for the screened individual compared with usual care 10. There should be agreed evidence-based policies covering which individuals should be offered interventions and the appropriate intervention to be offered | What is the most effective management pathway for women with screen-detected VP? |
What is the most effective management pathway for women with screen-detected VCI? |