Skip to main content

Table 1 Population Intervention Context Outcomes Study Design (PICOS)

From: Snakebite associated thrombotic microangiopathy: a protocol for the systematic review of clinical features, outcomes, and role of interventions

Population Humans (all ages) sustaining a snakebite with TMA features as defined by either histological biopsy or definite blood film features of microangiopathy (schistocytes or red cell fragments)
Intervention Plasmapheresis
Context Attending for medical care in any setting worldwide
Primary outcome Dialysis-free survival
Secondary outcomes Acute kidney injury
Other end organ damage
Overall survival
Study design All studies reporting original data