Snakebite associated thrombotic microangiopathy: a protocol for the systematic review of clinical features, outcomes, and role of interventions

Table 1 Population Intervention Context Outcomes Study Design (PICOS)

Population	Humans (all ages) sustaining a snakebite with TMA features as defined by either histological biopsy or definite blood film features of microangiopathy (schistocytes or red cell fragments)
Intervention	Plasmapheresis
Context	Attending for medical care in any setting worldwide
Primary outcome	Dialysis-free survival
Secondary outcomes	Acute kidney injury
	Other end organ damage
	Overall survival
Study design	All studies reporting original data

ISSN: 2046-4053