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Table 1 Population Intervention Context Outcomes Study Design (PICOS)

From: Snakebite associated thrombotic microangiopathy: a protocol for the systematic review of clinical features, outcomes, and role of interventions

Population

Humans (all ages) sustaining a snakebite with TMA features as defined by either histological biopsy or definite blood film features of microangiopathy (schistocytes or red cell fragments)

Intervention

Plasmapheresis

Context

Attending for medical care in any setting worldwide

Primary outcome

Dialysis-free survival

Secondary outcomes

Acute kidney injury

Other end organ damage

Overall survival

Study design

All studies reporting original data