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Table 1 Associations of mutations in P. falciparum with antimalarial resistance

From: Diagnostic accuracy of molecular methods for detecting markers of antimalarial drug resistance in clinical samples of Plasmodium falciparum: protocol for an update to a systematic review and meta-analysis

Gene Associated with susceptibility or resistance to
Chloroquine resistance transporter (pfcrt) Amodiaquine, chloroquine, lumefantrine, quinine
Cytochrome b (pfcytb) Atovaquone
Dihydrofolate reductase (pfdhfr) Cycloguanil, proguanil, pyrimethamine
Dihydropteroate synthase (pfdhps) Sulphadoxine
Kelch 13 (pfk13) Artemisinins
Multi-drug resistance 1 (pfmdr1) Amodiaquine, artemisinins, chloroquine, halofantrine, lumefantrine, mefloquine, piperaquine, quinine
Plasmepsin 2 (pfpm2) Piperaquine
Plasmepsin 3 (pfpm3) Piperaquine