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Table 2 AMSTAR ratings of included systematic reviews

From: Prophylactic management of postpartum haemorrhage in the third stage of labour: an overview of systematic reviews

Review title

AMSTAR criteria

Total score (maximum of 11)

“Apriori” design

Duplicate study selection and data extraction

Comprehensive literature search

Status of publication used as an inclusion criterion

List of studies (included and excluded) provided

Characteristics of the included studies provided

Scientific quality of the included studies assessed and documented

Scientific quality of the included studies used appropriately in formulating conclusions

Methods used to combine the findings of studies appropriate

Likelihood of publication bias assessed

Conflict of interest stated

Active management

 Cochrane reviews

  “Fundal pressure versus controlled cord traction as part of the active management of the third stage of labour” (Peña-Martí, 2007 [49])

Yes

Yes

Yes

Yes

Yes

Yes

N/A

N/A

N/A

N/A

Yes

7

  “Active versus expectant management for women in the third stage of labour” (Begley, 2015 [21])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

No

Yes

10

  “Controlled cord traction for the third stage of labour” (Hofmeyr, 2015 [23])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

11

 Non-Cochrane reviews

  “Preventing postpartum hemorrhage in low-resource settings” (McCormick, 2002 [48])

C/A

No

Yes

No

No

No

No

No

No

No

C/A

1

  “Active management of the third stage of labor with and without controlled cord traction: A systematic review and meta-analysis of randomized controlled trials” (Du, 2014 [47])

C/A

Yes

Yes

No

No

Yes

Yes

Yes

Yes

No

C/A

6

Pharmacological management (oxytocin)

 Cochrane reviews

  “Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour” (McDonald, 2004 [24])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

N/A

Yes

10

  “Timing of prophylactic uterotonics for the third stage of labour after vaginal birth” (Soltani, 2010 [27])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

N/A

Yes

10

  “Umbilical vein injection for the routine management of third stage of labour” (Mori, 2012 [25])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

N/A

Yes

10

  “Intramuscular versus intravenous prophylactic oxytocin for the third stage of labour” (Oladapo, 2012 [26])

Yes

Yes

Yes

Yes

Yes

Yes

N/A

N/A

N/A

N/A

Yes

7

  “Carbetocin for preventing postpartum haemorrhage” (Su, 2012 [28])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

11

  “Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage” (Westhoff, 2013 [29])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

11

  “Oxytocin for preventing postpartum haemorrhage (PPH) in non-facility birth settings” (Pantoja, 2016 [51])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

N/A

Yes

10

 Non-Cochrane reviews

  “Carbetocin for the prevention of postpartum hemorrhage: a systematic review and meta-analysis of randomized controlled trials” (Jin, 2016 [50])

C/A

Yes

Yes

No

No

No

Yes

No

Yes

Yes

Yes

6

Pharmacological management (prostaglandins)

 Cochrane reviews

  “Advance misoprostol distribution for preventing and treating postpartum haemorrhage” (Oladapo, 2012 [31])

Yes

Yes

Yes

Yes

Yes

Yes

N/A

N/A

N/A

N/A

Yes

7

  “Prostaglandins for preventing postpartum haemorrhage” (Tunçalp, 2012 [32])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

11

  “Postpartum misoprostol for preventing maternal mortality and morbidity” (Hofmeyr, 2013 [30])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

11

 Non-Cochrane reviews

  “Misoprostol use during the third stage of labor” (Joy, 2003 [53])

C/A

No

Yes

Yes

No

Yes

Yes

No

Yes

No

No

5

  “Misoprostol in preventing postpartum hemorrhage: a meta-analysis” (Langenbach, 2006 [54])

C/A

No

Yes

No

Yes

No

Yes

No

Yes

No

No

4

  “Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects” (Hofmeyr, 2009 [52])

C/A

Yes

Yes

Yes

No

No

C/A

No

Yes

No

Yes

5

  “Misoprostol for prevention and treatment of postpartum haemorrhage: a systematic review” (Olefile, 2013 [55])

C/A

Yes

Yes

C/A

No

Yes

Yes

No

Yes

Yes

Yes

7

Pharmacological management (ergot alkaloids)

 Cochrane reviews

  “Prophylactic use of ergot alkaloids in the third stage of labour” (Liabsuetrakul, 2007 [33])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

N/A

Yes

10

Pharmacological management (tranexamic acid)

 Cochrane reviews

  “Tranexamic acid for preventing postpartum haemorrhage” (Novikova, 2015 [59])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

N/A

Yes

10

 Non-Cochrane reviews

  “Anti-fibrinolytic agents in postpartum haemorrhage: a systematic review” (Ferrer, 2009 [55])

C/A

Yes

Yes

Yes

No

Yes

No

Yes

Yes

No

No

6

  “Efficacy and safety of tranexamic acid administration for the prevention and/or the treatment of post-partum haemorrhage: A systematic review with meta-analysis” (Faraoni, 2014 [56])

C/A

Yes

No

No

No

Yes

Yes

No

Yes

No

Yes

5

  “Prophylactic tranexamic acid in parturients at low risk for post-partum haemorrhage: Systematic review and meta-analysis” (Heesen, 2014 [58])

C/A

Yes

Yes

No

No

Yes

Yes

No

Yes

No

Yes

6

  “Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials” (Ker, 2016 [60])

Yes

No

Yes

Yes

No

Yes

Yes

Yes

No

No

Yes

7

Non-pharmacological management

 Cochrane reviews

  “Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes” (McDonald, 2013 [22])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

11

  “Uterine massage for preventing postpartum haemorrhage” (Hofmeyr, 2013 [61])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

N/A

Yes

10

  “Breastfeeding or nipple stimulation for reducing postpartum haemorrhage in the third stage of labour” (Abedi, 2016 [62])

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

N/A

Yes

10

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Systematic Reviews

ISSN: 2046-4053