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Table 7 Included study characteristics

From: Use of programme theory to understand the differential effects of interventions across socio-economic groups in systematic reviews—a systematic methodology review

Author

Intervention

Population/setting

Outcomes (relevant to SES)

Type of synthesis

Type of studies included

No. of studies included in review

Did review aim to consider ‘what works, for SES’? (Method of analysis)

SES focus

Backholer et al. [28]

Sugar-sweetened beverage tax

High-income countries

Differential effects on beverage purchases and consumption, weight, amount paid in SSB taxes

Narrative

Any study design

11

Bambra et al. [29]a; Hillier-Brown et al. [31]

Individual-, community- and societal-level interventions aimed at reducing inequalities in obesity

Children (0–18 years) in any setting in any country

Targeted/differential effects on proxy for body fat (weight and height, BMI, waist measurement/waist-to-hip proportion, percentage body fat content, skinfold thickness, ponderal index in relation to childhood obesity)

Meta-analysis/narrative

RCT, nRCT, prospective/retrospective cohort studies, prospective repeat cross-sectional studies

76 (25 measured differential effects by SES)

(descriptive analysis, sensitivity analysis)

Bambra et al. [29]a; Cairns et al. [32]; Hillier-Brown et al. [30]

Individual-, community- and societal-level interventions aimed at reducing inequalities in obesity

Adults (≥ 18 years) in any setting in any country

Targeted/differential effects on proxy for body fat (weight and height, BMI, waist measurement/ waist-to-hip proportion, percentage body fat content, skinfold thickness, ponderal index in relation to childhood obesity)

Meta-analysis/narrative

RCT, nRCT, prospective/retrospective cohort studies, prospective repeat cross-sectional studies

103 (36 measured differential effects by SES)

(descriptive analysis, sensitivity analysis)

Beauchamp et al. [33]

Public health obesity prevention

Interventions addressed everyone across the social gradient

Differential effects on change in anthropometric outcomes

Narrative

Any study design

14

(descriptive analysis)

Boelsen-Robinson et al. [34]

Whole of community obesity prevention

Interventions across different socio- economic strata

Differential effects on behavioural change, energy balance, anthropometric outcomes

Narrative

Any study design

13

(descriptive analysis)

Brown et al. [36]b, c; Brown et al. [35]

Community pharmacy delivered interventions focused on alcohol misuse, smoking cessation and weight management

People of any age in any country

Targeted/differential effects on behavioural outcome (e.g. quit rate, change in alcohol intake), weight loss interventions had to report anthropometric outcome

Meta-analysis/narrative

RCTs, nRCTs, CBAs, ITS and repeated measure studies

24

(descriptive analysis)

Brown et al. [37]

Population-level tobacco control

Adults (≥ 18 years) or studies which measured children’s reports of parental smoking in a country at stage 4 of the tobacco epidemic or in the WHO European Region

Differential effects on smoking related outcomes: Social norms/attitudes, exposure to second-hand smoke, policy reach, use of quitting services, quit attempts, smoking prevalence, morbidity

Narrative

All primary study designs, including: RCT, non-RCT, cohort studies, cross-sectional, qualitative

117

Brown et al. [38]

Individual-level smoking cessation interventions undertaken in Europe since 1995

Adults (≥ 18 years) based in a WHO European Region country

Differential effects on smoking cessation

Narrative

All primary research designs, including RCT, non-RCT, cohort studies, cross-sectional, qualitative

29

Brown et al. [39]

Population-level interventions/policy- and individual-level cessation support

Participants (birth–25 years) in a country in the WHO European Region or non-European country at stage 4 of the tobacco epidemic

Differential effects on smoking-related outcomes: Intentions/ attitudes/perceptions, exposure to second-hand smoke, smoking behaviour, sensitivity to price, initiation, relapse, cessation rates, smoking prevalence, morbidity

Narrative

All primary research designs, including RCT, non-RCT, cohort studies, cross-sectional, qualitative

38

Bull et al. [40]

Interventions targeting a change in smoking, eating and/or physical activity behaviours

Adults (≥ 18 years) of low income and from the general population

Behavioural outcomes relevant to smoking cessation, healthy eating and physical activity

Meta-analysis

RCTs and cluster RCTs

35

Cleland et al. [41]

Any intervention focused on increasing physical activity

Community-dwelling socio-economically disadvantaged women (19–64 years)

Physical activity outcome, or closely related (e.g. cardiorespiratory fitness)

Meta-analysis

RCTs, nRCTs

19

(subgroup-analysis, meta-regression)

Everson-Hock et al. [42]

Community-based physical activity and dietary

Adults (18–74 years) from a low SES group within the UK

Effectiveness, acceptability

Narrative (mixed-methods)

Quantitative intervention studies, qualitative evaluations of interventions, qualitative studies assessing beliefs and perceptions of physical activity

35

Gardner, et al. [43]

Interventions that aimed to increase mammography use

Asymptomatic low-income women

Uptake of mammography

Meta-analysis

RCT

21

(subgroup and meta-regression)

Hill et al. [44]

Tobacco control

Adults (≥ 18 years) in countries at an advanced stage of the tobacco epidemic

Targeted/differential effects on smoking related outcomes

Narrative

Reviews and primary research

84

Hollands et al. [45]c

Portion, package or tableware size

Adults and children directly engaged with manipulated products

Differential effects on behavioural outcomes (consumption or selection of food, alcohol, or tobacco products)

Meta-analysis/narrative

RCTs

70

(meta-regression)

Kader et al. [46]

Universal parental support targeting children’s health behaviours

At least one parent/caregiver of a child 2–18 years. with or without their child

Targeted/differential effects on children’s dietary habits, physical activity, sedentary behaviour, weight status

Narrative

Prospective studies assessing effectiveness of a controlled intervention

35 (6 with SES focus)

Kendrick et al. [47]

Home safety interventions

Children and young people (≤ 19 years) and their families

Differential effects on self-reported or medically attended injury in children/young people

Meta-analysis (IPD)/narrative

RCTs, nRCTs, CBA

98

Kristjansson et al. [48]

Supplementary feeding

Children (3 months–5 years) from socio-economically disadvantaged groups or all socio-economic groups with results stratified by SES

Targeted/differential effects on physical (growth), psychosocial health in children

Meta-analysis/narrative

RCTs, c-RCTs, CCT, CBA, ITS

32

(sub-group analysis and process evaluation)

Laba et al. [49]

Strategies to increase patient adherence to cardiovascular medications

Socioeconomically disadvantaged adults with prescribed medications for prevention/treatment of cardiovascular disease

Targeted/differential effects on patient adherence

Narrative

RCTs, quasi-RCTs

14

(descriptive analysis)

Laws et al. [50]

Obesity prevention

Healthy children (0–5 years from) socioeconomically disadvantaged or Indigenous families

Targeted/differential effects on anthropometric measures, child/family diet, parental feeding practices related to obesity, physical activity, sedentary behaviours

Narrative

Any study design

32

(descriptive analysis)

Magnee et al. [51]

Obesity prevention

Participants included within studies identified from a systematic inventory (1990–2007) of Dutch obesity prevention interventions

Differential effects on anthropometric measures, obesity-related behavioural outcomes (e.g. diet, physical activity)

Narrative

Studies selected from a systematic inventory (1990–2007) of Dutch obesity prevention interventions

26

McGill et al. [52]

Promotion of healthy eating

Healthy populations (any age/gender)

Differential effects on dietary intake

Narrative

Any study design measuring effects of intervention

36

(descriptive analysis)

McLean et al. [20]d

Reminder systems for scheduled health service encounters

Examined differential effectiveness across particular subgroups of the population (age, gender, ethnic group, SES, etc.)

Differential effects on improving uptake

Thematic/narrative

Effectiveness review: RCTs, SRs

Realist informed review: studies examining effectiveness of outpatient appointment reminders, qualitative/quantitative designs on appointment attendance behaviour, studies of adherence to treatment, theories/ models/frameworks relating to appointment attendance

Effectiveness review: 42

Realist informed review: 463

(descriptive analysis, realist informed review)

Mizdrak et al. [53]

Food/beverage price change

NR

Differential response in purchase of targeted foods

Narrative

Controlled experimental study

8

(descriptive analysis)

Moore et al. [54]

Universal school-based health behaviour

School children (4–18 years)

Differential effects on diet, physical activity, smoking, alcohol

Narrative

RCTs, quasi-experimental studies

20

(content analysis)

Moredich et al. [55]

Physical activity and weight loss

Low-income adult women

Change in weight

Integrative

Intervention studies

7

(descriptive analysis)

Rojas-Garcia et al. [56]

Healthcare interventions to treat depressive disorders

Socially disadvantaged patients with depressive disorders

Reduction of depressive symptoms

Meta-analysis/narrative

Controlled trials including RCTs & quasi-experimental studies

15

(meta-regression)

Sarink et al. [57]

Menu labelling

Adolescents or adults of a low SEP population or analysis stratified by a measure of SEP

Targeted/differential effects on awareness of exposure, understanding, food or energy purchased or consumed, body mass index

Narrative

Quantitative and qualitative

18

SES accounted for

Ciciriello et al. [58]e

Multimedia-based patient education about prescribed or over the counter medications

People of all ages prescribed a particular medication or medication regimen or who had obtained an over-the-counter medication

Patient or carer knowledge about the medication, any measure of skill acquisition related to the medication

Meta-analysis/narrative

RCTs, quasi-RCTs

24

Ejemot-Nwadiaro et al. [59]e

Hand-washing promotion

Adults and children in day care centres or schools, patients in hospitals, communities or households

Episodes of diarrhoea

Meta-analysis/narrative

RCTs, cluster RCTs

22

Gittelsohn et al. [60]

Community-based prepared food sources

NR

Access to and consumption of healthful foods (psychosocial factors (awareness, knowledge, acceptability), behaviour, frequency of use, frequency of purchase, increase in healthful food sales)

Narrative

Some form of written documentation that included a description of the intervention and evaluation

19

Gurol-Urganci et al. [61]e

Mobile phone messaging reminders

All study participants, regardless of age, gender, ethnicity

Rate of attendance at healthcare appointments

Meta-analysis

RCTs

8

Hartmann-Boyce et al. [62]

Self-help

Adults (≥ 18 years) with body mass index ≥ 25 kg/m2

Targeted/differential effects on change in weight

Meta-analysis/narrative

RCTs

23

(meta-regression)

Kroon et al. [63]

Structured self-management education programmes for osteoarthritis (OA)

People diagnosed with OA

Self-management of OA, participant’s positive and active engagement in life, pain, global OA scores, self-reported function, quality of life, withdrawals

Meta-analysis

RCTs, quasi-RCTs

29

Lutge et al. [64]c

Any material inducement to return for TB test results or adhere to or complete anti-TB preventive or curative treatment

People receiving curative treatment for active TB, people receiving preventive therapy for latent TB or people suspected of TB undergoing, and collecting results of, diagnostic tests

Cure or completion of treatment, cases of active TB; completion of prophylactic treatment, number returning to collect test results within the appropriate time frame for that test.

Meta-analysis/narrative

RCTs

12

Pega et al. [65]c

In-work tax credits

Working age adults (18–64 years)

Self-rated general health, mental health or physical distress, mental illness, overweight and obesity, alcohol use, tobacco use

Narrative

CBA, ITS

5

Polec et al. [66]c

Interventions that aimed to increase the ownership and appropriate use of insecticide-treated bednets (ITN)

Children and adults with permanent residence in malarial areas

ITN ownership, appropriate ITN use

Meta-analysis/narrative

RCTs, cluster RCTs, non-RCTs, CBA, ITS

10

  1. Abbreviations: SEP socio-economic position, SES socioeconomic status, RCT randomised controlled trial, nRCT non-randomised controlled trial, quasi-RCT quasi-randomised controlled trial, cluster RCT cluster randomised controlled trial, SR systematic review, CBA controlled before-and-after study, ITS interrupted time series, NR not reported
  2. aTwo studies reported across four publications
  3. bOne study reported in two publications
  4. cSubgroup analysis planned by SES but not undertaken
  5. dOne study undertook two systematic reviews relating to effectiveness and ‘what works, for whom, under what circumstance in relation to SES populations
  6. eData collected on SES variables, but no analysis undertaken