Table 3 Subgroup analyses by RT-PCR assay type
RT-PCR assay type | Summary measure of test accuracya (95% CI) | Test for heterogeneity | ||
|---|---|---|---|---|
(χ 2) (df = 24) | (I 2) | p value | ||
CobasTaqMan (n = 17; b19,814) AUC = 0.98 | ||||
 Sensitivity | 0.78 (0.76–0.80) | 205.13 | 92.20% | < 0.001 |
 Specificity | 0.99 (0.99–0.99) | 127.21 | 87.40% | < 0.001 |
 Positive likelihood ratio (PLR) | 41.59 (27.80–62.18) | 98.14 | 83.70% | < 0.001 |
 Negative likelihood ratio (NLR) | 0.18 (0.13–0.23) | 134.36 | 88.10% | < 0.001 |
 Diagnostic odds ratio (DOR) | 273.14 (181.45–411.17) | 47.6 | 66.40% | < 0.001 |
Light Cycler (n = 7; b1159) AUC = 0.97 | ||||
 Sensitivity | 0.85 (0.80–0.88) | 61.71 | 90.30% | < 0.001 |
 Specificity | 0.99 (0.98–0.99) | 10.09 | 40.50% | 0.121 |
 Positive likelihood ratio (PLR) | 21.65 (6.82–68.72) | 17.45 | 65.60% | 0.008 |
 Negative likelihood ratio (NLR) | 0.17 (0.08–0.38) | 63.77 | 90.60% | < 0.001 |
 Diagnostic odds ratio (DOR) | 150.52 (31.97–708.78) | 20.35 | 70.50% | < 0.002 |
Cepheid and others (n = 22; b14,839) AUC = 0.99 | ||||
 Sensitivity | 0.78 (0.77–0.80) | 729.43 | 97.10% | < 0.001 |
 Specificity | 0.99 (0.99–0.99) | 299.13 | 93.00% | < 0.001 |
 Positive likelihood ratio (PLR) | 38.50 (19.65–75.42) | 234.62 | 91.00% | < 0.001 |
 Negative likelihood ratio (NLR) | 0.22 (0.15–0.33) | 594.30 | 96.50% | < 0.001 |
 Diagnostic odds ratio (DOR) | 221.44 (94.94–516.51) | 208.25 | 89.90% | < 0.001 |