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Table 2 Secondary and safety outcome measures

From: High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis

Outcome or subgroup   Participants Effect estimate
(95% CI)
I 2 (UCI)
Studies Intervention Control
Patient tolerance [26, 30] 2 n = 126 n = 227 SMD − 0.63
(− 1.11, − 0.15)
54%
Intubation [26, 27, 29, 31, 34] 5 113/764 176/841 RR 0.85
(0.70, 1.04)
0% (0%, 74%)
Cardio-respiratory arrest [26,27,28, 34] 3 5/341 13/207 RR 0.65
(0.26, 1.62)
0%
(0%, 87%)
PaO2:FiO2 a [26, 27] 2 n = 520 n = 623 MD − 53.34
(− 71.95, − 34.72)
61%
pHa [26, 27] 2 n = 520 n = 623 MD 0.01 (0.00, 0.01) 36%
PaCO2 a [26, 27] 2 n = 520 n = 623 MD − 0.66
(− 1.47, 0.16)
67%
  1. HFNC high-flow nasal cannulae, I 2 I-squared, UCI uncertainty intervals
  2. aRating at 6–12 h post-randomization