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Table 2 Search strategy example used in PubMed database

From: Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism—protocol for a systematic review

Number

Search terms

Number of articles

1

Hypothyroidism OR thyroid stimulating hormone OR TSH OR levothyroxine OR LT4 OR thyroid replacement therapy [Title] [Abstract]

5443

2

Food OR Soy OR Coffee OR Caffeine OR Fibre [Title] [Abstract]

65014

3

Comorbid OR comorbidity OR lactose intolerance OR coeliac disease OR celiac disease OR pernicious anaemia OR Vitamin B12 deficiency OR anaemia gastritis OR type 2 diabetes OR pancreatic disease OR pancreatitis OR liver disease [Title] [Abstract]

62790

4

Concomitant OR compliance OR adherence OR levothyroxine AND dose [Title] [Abstract]

56842

5

Attitudes OR perceptions [Title] [Abstract]

26370

6

Co-administration OR proton pump inhibitors OR omeprazole OR lansoprazole OR lanthanum carbonate OR calcium AND medication OR antacids OR sevelamer hydrochloride OR cholestyramine OR colesevelam OR ferrous sulphate OR aluminium hydroxide [Title] [Abstract]

4819

7

OATP1 OR MCT OR UGT OR FOXE OR deiodinase OR polymorphism [Title] [Abstract]

32483

8

1 AND 2

890

9

1 AND 3

205

10

1 AND 4

202

11

1 AND 5

10

12

1 AND 6

18

13

1 AND 7

153