Skip to main content

Table 1 Demographic data for 75 randomised controlled trials (RCTs) of non-individualised homeopathy: 21 excluded from meta-analysis shown by italics at first author's name

From: Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis

# First author Year Category Condition Acute/ Chronic Participants’ demographics Study setting Potency ≥12C Hom. type Funding source Free of vested interest a
A42 Aabel 2001 Allergy and Asthma Seasonal allergic rhinitis Acute Patients treated for hay fever due to birch pollen allergy Specialist outpatient department in Norway Y Isopathy Research Council of Norway. Homeopathic remedy and placebo tablets were gift from DCG, Gothenburg, Sweden N
A43 Aabel 2000 Allergy and Asthma Seasonal allergic rhinitis Acute Patients treated for hay fever due to birch pollen allergy Specialist outpatient department in Norway Y Isopathy Research Council of Norway. Homeopathic remedy and placebo tablets were gift from DCG, Gothenburg, Sweden N
A44 Aabel 2000 Allergy and Asthma Seasonal allergic rhinitis Acute Patients treated for hay fever due to birch pollen allergy Specialist outpatient department in Norway Y Isopathy Research Council of Norway. Homeopathic remedy and placebo tablets were gift from DCG, Gothenburg, Sweden N
A47 Baker 2003 Mental Disorder Anxiety Acute Anxious students, aged 18-60 years University, Australia N Single ‘Brauer Biotherapies Pty Ltd (Adelaide) manufactured the homeopathic preparation specifically for the study’ U
A48 Balzarini 2000 Dermatology Radiodermatitis Acute Patients with dermatitis caused by radiotherapy for breast cancer Rehabilitation and palliative care department, Italy Mixed Combn. None stated U
A49 Beer 1999 Obstetrics and Gynaecology Induction of labour Acute Women (at least 18 years old) between 38 and 42 weeks’ gestation and cervical dilation (≤3 cm) Akademisches Lehrkrankenhaus der RWTH Aachen N Single None stated U
A50 Belon 2006 Toxicology Arsenic toxicity Chronic People at high risk of arsenic contamination Rural village, India Y Single Hom pharm N
A51 Belon 2007 Toxicology Arsenic toxicity Chronic People at high risk of arsenic contamination Rural village, India Y Single Hom pharm N
A52 Bergmann (a) 2000 Obstetrics and Gynaecology Female infertility: oligomenorrhoea Chronic Women, age 18 - 40 Universitäts-Frauenklinik Heidelberg N OTC complex None stated U
A52 Bergmann (b) 2000 Obstetrics and Gynaecology Female infertility: amenorrhoea Chronic Women, age 18 - 40 Universitäts-Frauenklinik Heidelberg N OTC complex None stated U
A53 Bernstein 2006 Dermatology Psoriasis Acute Patients with psoriasis Dermatology Centre in the USA N Single “Supported in part” by Apollo Pharmaceuticals Inc., manufacturers of Reliéva N
A55 Berrebi 2001 Obstetrics and Gynaecology Postpartum lactation Acute Women immediately after childbirth and who did not wish to breast-feed Childbirth unit, university hospital, Toulouse, France N Combn. Hom pharm N
A56 Bignamini 1987 Cardiovascular Hypertension Chronic Elderly males or females with hypertension Two old people’s homes, Italy Y Single “We thank Laboratoires Boiron for material provided” U
A59 Cialdella 2001 Mental Disorder Withdrawal of benzodiazepines Chronic Men and women aged >18 years, taking BZD for >3 mo. GP practices in France (multi-centre) N OTC complex b External (hom pharm / govt.) N
A60 Clark 2000 Musculoskeletal Plantar fasciitis Acute Patients treated with heel pain due to fasciitis Podiatry clinic, England Y Single None stated U
A272 Colau 2012 Obstetrics and Gynaecology Menopausal syndrome Chronic Women aged ≥50 years; experienced amenorrhea for >12 months; spontaneously complained of hot flashes that had started <2 years previously 35 gynaecologist private practices in France N OTC complex Hom pharm. N
A61 Cornu 2010 Surgery and Anaesthesiology Post-operative bleeding Acute Males or females, >18 years old, for whom elective aortic valve surgery planned University hospital department, France N Combn. Financially supported and assisted in design by Laboratoires Boiron, but ‘conducted in total independence’ U
A62 Diefenbach 1997 Respiratory Infection Bronchitis Acute Patients (M/F) with bronchitis 4 doctors’ practices in Germany N OTC complex None stated U
A63 Ernst 1990 Cardiovascular Varicose veins Acute Varicose veins in the legs Rehabilitation clinic in Austria N OTC complex None stated U
A64 Ferley 1989 Respiratory Infection Influenza Acute Age ≥12 years, flu-like symptoms, temp ≥38C General practices in Rhône-Alpes region, France Y aIsopathy None stated U
A67 Frass 2005 Respiratory Infection Tracheal secretions Acute Patients with accumulation of heavy secretions in the trachea Intensive Care Unit at a university hospital in Austria Y Single None stated U
A68 Freitas 1995 Allergy and Asthma Childhood asthma Chronic Children aged 12 mo to 12 years, with a mild to severe asthma crisis in the previous 6 mo. Outpatient clinic in São Paulo, Brazil N Single None stated U
A69 Friese 2007 Ear, Nose and Throat Sinusitis Acute Patients from 18 - 65 (m/f) 10 medical centres in Ukraine N OTC complex None stated U
A70 Friese 1997 Ear, Nose and Throat Adenoid Acute Children (M/F) between age 4 and 10 Universitäts Kinderklinik Tübingen Mixed Combn. Remedies were gift from hom pharm. N
A74 Gerhard (a) 1998 Obstetrics and Gynaecology Female infertility: amenorrhoea Chronic Women with secondary amenorrhoea University hospital, Germany N OTC complex Direct support from the company that provided the homeopathic medicine for the trial (senior author is company employee) N
A74 Gerhard (b) 1998 Obstetrics and Gynaecology Female infertility: luteal insufficiency Chronic Women with luteal insufficiency University hospital, Germany N OTC complex Direct support from the company that provided the homeopathic medicine for the trial (senior author is company employee) N
A74 Gerhard (c) 1998 Obstetrics and Gynaecology Female infertility: idiopathic Chronic Women with idiopathic infertility University hospital, Germany N OTC complex Direct support from the company that provided the homeopathic medicine for the trial (senior author is company employee) N
A75 GRECHO 1989 Surgery and Anaesthesiology Post-operative ileus Acute Men and women aged >18 years, having one of several stated operations 12 hospitals in France Mixed Combn. Govt. Y
A274 Harrison 2013 Mental Disorder Insomnia Chronic Males aged 18-40, with chronic primary insomnia: at least 3 days per week for period of 1 mo to 10 years University clinic N Combn. University Y
A76 Hart 1997 Surgery and Anaesthesiology Post-operative pain Acute Patients with abdominal hysterectomy Hospital, England Y Single None stated U
A78 Hitzenberger 2005 Cardiovascular Hypertension Chronic Hypertensive patients (M/F) Not explicitly mentioned N OTC complex The study was funded, but it is not stated by whom U
A79 Hofmeyr 1990 Obstetrics and Gynaecology Postpartum pain Acute Postpartum women with episiotomy or perineal tearing requiring suture University hospital, South Africa N Single b None stated U
A80 Jacobs 2006 Gastroenterology Childhood diarrhoea Acute Children with a history of acute diarrhoea Two municipal clinics, Honduras Y Combn. External (hom research foundation) Y
A81 Jacobs 2007 Tropical Disease Dengue fever symptoms Acute Patients over age 12 with a case definition of dengue Two health centres, Honduras Y Combn. External (hom research foundation); meds ‘furnished’ by hom pharm U
A83 Kaziro 1984 Surgery and Anaesthesiology Post-operative pain/swelling Acute Patients with extraction of impacted wisdom teeth Dental hospital, England Y Single None stated U
A84 Khuda-Bukhsh 2005 Toxicology Arsenic toxicity Chronic People at high risk of arsenic contamination Rural village, India Y Single Hom pharm. N
A85 Khuda-Bukhsh 2011 Toxicology Arsenic toxicity Chronic People at high risk of arsenic contamination Rural village, India Y Single Hom pharm. N
A86 Kim 2005 Allergy and Asthma Seasonal allergic rhinitis Acute Asthmatic people allergic to house dust mite College of Naturopathic Medicine and Health Sciences, USA N Isopathy Internal / External (hom pharm) N
A88 Kolia-Adam 2008 Mental Disorder Insomnia Chronic Males or females, 18-50 years, suffering from insomnia for > 1 year University health clinic, South Africa Y Single None stated U
A89 Kotlus 2010 Surgery and Anaesthesiology Post-operative bruising Acute Males undergoing upper blepharoplasty University department of ophthalmology, USA Y Combn. Supported in part by external foundation Y
A91 Labrecque 1992 Dermatology Warts Chronic Aged 6-59 years and at least 1 plantar wart untreated during previous 3 months Hospital-based family medicine unit, Canada Mixed Combn. Hospital pharmacy Y
A92 Leaman 1989 Dermatology Minor burns Acute Aged 15-60 years with minor burns within previous 6 h Hospital Accident and Emergency Dept, England Y Single None stated U
A93 Lewith 2002 Allergy and Asthma Allergic asthma Chronic Asthmatic people allergic to house dust mite Hospital clinic, England Y Isopathy Internal / External (charity) / Purchase from hom pharm Y
A94 Lipman 1999 Miscellaneous Snoring Acute People treated for snoring ENT specialist clinic in the USA N OTC complex None stated U
A293 Malapane 2014 Ear, Nose and Throat Tonsillitis Acute Children, aged 6-12 years, with acute viral tonsillitis University department of homeopathy, South Africa N OTC complex None stated U
A95 McCutcheon 1996 Mental Disorder Anxiety Acute Adults with above average anxiety University, USA N OTC complex Hom pharm N
A275 Naidoo 2013 Allergy and Asthma Allergic skin reaction Acute Males or females, aged 18 to 45; positive skin test; living with a cat for a period of ≥ 6 mo; suffering from allergy-like symptoms University health training centre N Combn. None stated U
A100 Oberbaum 2001 Oral/Dental Stomatitis Acute Cancer patients with stomatitis Children’s Medical Centre in Israel N OTC complex None stated U
A101 Oberbaum 2005 Obstetrics and Gynaecology Postpartum bleeding Acute Women after childbirth Medical centre in Israel Mixed Combn. Research foundation Y
A103 Padilha 2011 Toxicology Lead poisoning Acute Workers at risk of lead contamination Clinic of battery plant, Brazil Y Single Explicitly no funding source Y
A104 Papp 1998 Respiratory Infection Influenza Acute Age 12-60 years, specified flu-like symptoms, onset within last 24 h, temp ≥38C General or specialist medical practices, Germany Y a Isopathy None stated U
A105 Paris 2008 Surgery and Anaesthesiology Post-operative analgesic intake Acute Male or female, aged 18-60 years, undergoing surgery of anterior cruciate ligamen University hospital, France N Combn. Hom pharm N
A108 Rahlfs 1976 Gastroenterology Irritable bowel syndrome Acute Patients, male or female, aged 20-60, with diagnosis of irritable bowel syndrome 12 general medical practices in Germany N Single b None stated U
A109 Rahlfs 1978 Gastroenterology Irritable bowel syndrome Acute Patients, male or female, aged 20-60, with diagnosis of irritable bowel syndrome 39 general medical practices in Germany N Single External (hom research foundation) Y
A277 Razlog 2012 Mental Disorder ADHD Chronic School children, aged 5-11, diagnosed with ADHD Primary schools in South Africa N Single University Y
A111 Reilly 1986 Allergy and Asthma Seasonal allergic rhinitis Acute Patients aged over 5 with at least a 2-year history of seasonal rhinitis and current symptoms of grass pollen allergy Two hospital clinics and 26 NHS general practitioners in the UK Y Isopathy External: charity; govt. Y
A112 Reilly 1994 Allergy and Asthma Allergic asthma Chronic Patients aged over 16 with at least a 1-year history of asthma and reactive to inhaled allergens Asthma outpatient clinic, Scotland Y Isopathy External / purchase from hom pharm Y
A113 Robertson 2007 Surgery and Anaesthesiology Post-operative pain Acute Patients over the age of 18 undergoing tonsillectomy Hospital, England Y Single Internal / External (hom pharm) N
A116 Schmidt 2002 Miscellaneous Those benefited by reduced body weight Acute Fasting patients encountering static or increased body weight Hospital for internal and complementary medicine, Germany Y Single “The foundation of the Krankenhaus für Naturheilweisen funded the study, paying salaries or fees to contributors and collaborators.” U
A117 Seeley 2006 Surgery and Anaesthesiology Post-operative bruising Acute Female patients undergoing elective rhytidectomy Hospital, Canada Unknown Single Hom pharm. N
A278 Sencer 2012 Oral/Dental Mucositis Acute Patients aged 3-25 years, undergoing myeloablative haematopoietic SCT for malignant and non-malignant conditions Oncology centres in USA, Canada and Israel N OTC complex Government (NIH) grant Y
A120 Singer 2010 Surgery and Anaesthesiology Post-operative pain Acute Patients (M/F) age > = 18 2 centres N OTC complex Financial support by producing company which ‘supplied the study medication’ but, by contractual agreement, had ‘no control over the flow of the study, the data analysis, or the decision when and where to publish the study findings’ Y
A122 Stevinson 2003 Surgery and Anaesthesiology Post-operative pain/swelling Acute Aged 18–70 years undergoing elective hand surgery for carpal tunnel syndrome Hospital, England Y / N Single b Hom. research foundation / drugs ‘supplied by’ hom pharm U
A123 Taylor 2000 Allergy and Asthma Perennial allergic rhinitis Chronic Patients with allergy to house dust mites, animals, pollens or foods Specialist outpatient department in the UK Y Isopathy External (hom and non-hom charities) Y
A125 Tveiten 1991 Musculoskeletal Muscle soreness Acute Male marathon runners, Norway City of Oslo Y Single None stated U
A126 Tveiten 1998 Musculoskeletal Muscle soreness Acute Marathon runners, Norway City of Oslo Y Single Research Council of Norway. Homeopathic remedy and placebo tablets were gift from hom pharm. N
A128 Vickers 1998 Musculoskeletal Muscle soreness Acute Long-distance runners, aged 18 or over, England London community Y Single Charity / drugs gifted by hom pharm N
A130 Weiser 1994 Ear, Nose and Throat Sinusitis Chronic Patients (M/F) with chronic sinusitis 11 ENT doctors’ practices in Germany N OTC complex b None stated U
A131 Wiesenauer 1985 Allergy and Asthma Seasonal allergic rhinitis Acute Patients treated for hay fever Doctors’ practices in Germany N Single External (hom pharm) N
A132 Wiesenauer 1989 Ear, Nose and Throat Sinusitis Acute Patients (M/F) with acute or chronic sinusitis 47 doctors’ practices N Combn. c Funded by two foundations Y
A133 Wiesenauer 1990 Allergy and Asthma Seasonal allergic rhinitis Acute M/F, all ages 54 doctors’ practices N Single Funded by two foundations Y
A134 Wiesenauer 1991 Rheumatology Rheumatoid arthritis Chronic Patients (m/f), age 18 - 70, with chronic polyarthritis 6 doctors’ practices N OTC complex None stated U
A135 Wiesenauer 1995 Allergy and Asthma Seasonal allergic rhinitis Acute Patients treated for hay fever Doctors’ practices in Germany N Single None stated U
A136 Wolf 2003 Surgery and Anaesthesiology Post-operative pain Acute Age 10 - 65 (M/F), varicose veins Gefäßchirurgische Klinik in Berlin-Buch N Single Remedies were gift from hom pharm. N
A137 Zabolotnyi 2007 Ear, Nose and Throat Sinusitis Acute Patients, aged 18-60 years, treated for acute maxillary sinusitis, with at least 8 d of symptoms ENT specialist clinics, Ukraine N OTC complex None stated U
  1. Y yes, U unclear, N no, Combn. combination, M/F male/female
  2. aVested interest: support (direct, through research sponsorship; indirect, via gifted medicines) from company that provided homeopathic medicines for the trial
  3. bSingle RCT comprising two homeopathy groups
  4. cSingle RCT comprising three homeopathy groups