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Table 3 TMS-specific components of methodological quality

From: The number of stimuli required to reliably assess corticomotor excitability and primary motor cortical representations using transcranial magnetic stimulation (TMS): a systematic review and meta-analysis

Controlled/reported Bastani et al. [22] Christie et al. [23] Doeltgen et al. [25] Lewis et al. [24]
Participant factors
 Age of subjects Y Y Y Y
 Gender of subjects Y Y Y Y
 Handedness of subjects Y Y Y Y
 Subjects prescribed medication N N Y N
 Use of CNS active drugs (e.g. anti-convulsants) N N Y Y
 Presence of neurological/psychiatric disorders N N Y Y
 Any medical conditions N N Y Y
 History of specific repetitive motor activity N N Y N
Methodological factors
 Position and contact of EMG electrodes Y Y Y Y
 Amount of contraction of target muscles Y Y Y Y
 Prior motor activity of the muscle to be tested Y Y Y Y
 Relaxation of muscles other than those tested N N N N
 Coil type (size and geometry) Y Y Y Y
 Coil orientation Y Y Y Y
 Direction of induced current in the brain Y N N Y
 Coil location and stability Y Y Y Y
 Type of stimulator used (e.g. brand) Y Y Y Y
 Stimulation intensity Y Y Y Y
 Pulse shape (monophasic or biphasic) N N N Y
 Determination of optimal hotspot Y Y Y Y
 The time between MEP trials N N N Y
 Time between days of testing Y Y Y Y
 Subject attention (level of arousal) during testing N N N Y
 Method for determining threshold (active/resting) Y Y Y Y
 Number of MEP measures made Y Y Y Y
 Method for determining MEP size during analysis Y Y Y Y
Total score/26 17 16 21 23