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Table 2 Summary of study design and outcomes of included studies
| Author | Study design | Outcomes | |||||
|---|---|---|---|---|---|---|---|
| Wound healing | Ipsilateral reamputation | Quality of life | Functional ability | Mobility | Proportionate mortality | ||
| Andrews et al. [77] | Cohort—retrospective | Healed at 3 and 12 months | |||||
| Boutoille et al. [38] | Case control | Medical Outcome Study Short Form 36 (MOS SF-36) | |||||
| Brown et al. [17] | Cohort—retrospective | Volpicelli ambulatory scale | Mortality at 1, 3, 5 years | ||||
| Czerniecki et al. [76] | Cohort—prospective | Locomotor capabilities index 5 | |||||
| Czerniecki et al. [34] | Cohort—prospective | Locomotor capabilities index 5 | |||||
| Dillingham and Pezzin [66] | Cohort—retrospective | Reamputation at 1 year | Mortality at 1 year | ||||
| Dillingham et al. [28] | Cohort—retrospective | Mortality at 1 year | |||||
| Evans et al. [18] | Cohort—retrospective | Healed at 1 year | Reamputation at 1 year | Mortality at 2 years | |||
| Glaser et al. [65] | Cohort—retrospective | Reamputation at 1 and 5 years | Mortality at 1, 3, 5 years | ||||
| Griffin et al. [59] | Cohort—retrospective | Mortality at 30 days and 1 year | |||||
| Hambleton et al. [63] | Case control | Mortality at 3 and 6 months and 1 and 5 years | |||||
| Izumi et al. [27, 67] | Cohort—retrospective | Reamputation at 1, 3, 5 years | Mortality at 10 months and 5 years | ||||
| Jindeel and Narahara [68] | Cohort—retrospective | Mortality at 1 and 5 years | |||||
| Jones and Marshall [69] | Cohort—retrospective | Mortality at 3 and 5 years | |||||
| Kono and Muder [70] | Cohort—retrospective | Reamputation at 6 months and 3 year | Mortality at 3 years | ||||
| Kristensen et al. [61] | Cohort—retrospective | Mortality at 30 days and 1 year | |||||
| Lakstein et al. [64] | Cohort—retrospective | Healed at 3 weeks | Reamputation at 4 weeks | ||||
| Marzen-Groller et al. [75] | Cohorta | Modified functional independence measure | |||||
| Mayfield et al. [71] | Cohort—retrospective | Mortality at 30 days and 5 years | |||||
| Norvell et al. [33] | Cohort—prospective | Locomotor capabilities index 5 | |||||
| Peters et al. [35] | Cohort—retrospective | Sickness impact profile | Sickness impact profile | ||||
| Quigley et al. [36] | Cross-sectional | Medical Outcome Study Short Form 36 (MOS SF-36 version 2) | |||||
| Sandnes et al. [72] | Cohort—retrospective | Mortality at 30 days, 1 and 5 years | |||||
| Sheahan et al. [73] | Cohort—retrospective | Mortality at 30 days, 1 and 5 years | |||||
| Stone et al. [74] | Cohort—retrospective | Healed at 3 months | Mortality at 60 days, 1, 3 and 5 years | ||||
| Vamos et al. [60] | Cohort—retrospective | Mortality at 30 days and 1 year | |||||
| Winell et al. [62] | Cross-sectional | Mortality at 2 years | |||||
| Younger et al. [58] | Case control | Reamputation at 1 year | |||||
