Outcomes | No. of participants (studies) Follow-up | Quality of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects | |
---|---|---|---|---|---|
Risk with placebo | Risk difference with psychostimulants | ||||
Abstinence from illicit amphetamines and methamphetamines (final 2 weeks of treatment) Assessed with: urinalysis | 642 (5 RCTs) | ⨁◯◯◯ Very lowa,b,c,d,e | OR 0.97 (0.65 to 1.45) | 215 per 1000 | 5 fewer per 1000 (64 fewer to 69 more) |
Retention in treatment (end of trial) Follow-up: range 8 to 24 weeks | 1184 (14 RCTs) | ⨁◯◯◯ Very lowb,c,d,e,f | OR 1.20 (0.91 to 1.58) | 480 per 1000 | 46 more per 1000 (23 fewer to 113 more) |