Characteristic | Criteria |
---|---|
Population | Patients (including adults and children) with potentially reversible severe acute hypercapnic respiratory failure or being considered for lung transplantation |
Intervention | ECCO2R system including VV and AV setups |
Comparator | Because this systematic review focuses on adverse effects, any comparative and non-comparative studies will be included |
Outcome measure | Any adverse effects including but not limited to arterial, venous and device thrombus formation; plasma leakage from gas exchange device; vascular access damage; infections; complications requiring surgery including lower limb amputation; gas embolism; haemolysis and heparin-induced thrombocytopenia |
Study design |  • Clinical trials and observational studies (including cohort studies, case-control studies, cross-sectional studies and case reports)  • Systematic reviews, meta-analyses and narrative reviews will be included for identification of relevant primary studies |
Language | Only English language literature will be included |