Strain
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e.g., Sprague-Dawley versus Fischer 344
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Species
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Rat, mouse, dog, pig, etc.
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Age
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Age in weeks, body weight
|
Gender
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Male versus female versus mix of genders used
|
Model of PAH
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MCT, CH, or SUHx
|
Severity of PAH
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RVSP or mPAP in control group
|
Cell preservation
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Fresh versus fresh from previously cryopreserved versus thawed cryopreserved product
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Tissue source of regenerative cell product
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Bone marrow versus peripheral blood versus cord blood
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Timing of cell administration following induction of PAH
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Early (<2 weeks) versus late (≥2 weeks) intervention
|
Follow-up duration
|
Primary outcome assessed at 1, 2, 3, and 4+ weeks after intervention
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Route of cell administration
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Intravenous versus intratracheal versus intraperitoneal versus intramuscular
|
Dose of cells
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e.g., 1 × 106 cells
|
Type of control
|
PBS versus normal saline versus fibroblasts versus heat-killed cells
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Cell modification
|
Yes versus No
|
Number of participating study centers
|
Single versus multi-center
|