Table 1 Search strategy for research questions: Does early glycaemic control (intervention within two years post diagnosis) in childhood-onset T1D have an impact on subsequent risk of complications in childhood and adulthood? What are the predictors of early glycaemic control?

Childhood or paediatric onset diabetes or juvenile diabetes diagnosis or newly diagnosed children or young persons or young people or children or young or adolescent or teen or youth or adult T1D patient or type 1 diabetes or T1D or type 1 diabetes mellitus or T1DM or DM1 or type 1 or IDDM or insulin dependent or non-insulin dependent or childhood onset diabetes or childhood onset T1D or auto-immune or autoimmune or sudden onset or uncontrolled or labile or brittle

Early diabetes control or HbA1c trajectories or HbA1c trends or glycaemic trajectories or glycosylated or HbA1c or A1c or Hemoglobin A or HbA(1c) level or glycaemic control or glucose control or diabetes control or early intensive intervention or intensive or conventional or standard or regular or optimised or tight control or strict control or usual or routine or therapy or treatment or intervention or management or insulin use or injection or dose insulin injections or intensive therapy or insulin pump

Diabetic or diabetes complications or complications or side effects or adverse events or acute complications or chronic complications or glycaemia or hyper glycaemia or hypo glycaemia or ketosis or diabetic ketoacidosis or DKA or nonketotic hyperosmolar coma or insulin resistance or autoimmune disease or urine albumin or urine albumin creatinine ratio or urine albumin excretion or microalbuminuria or macroalbuminuria or renal disease or diabetic nephropathy or nephropathy or dialysis or foot ulcer or amputation or retinopathy or blindness or vascular disease or vascular complications or microvascular disease or microvascular complications or macrovascular disease or macrovascular complications or cardiovascular disease or MI or myocardial infarction or stroke or coronary artery disease or cerebrovascular disease or peripheral vascular disease or blood pressure or BP or statin or death or mortality or Pathology or metabolism or metabolic memory