Table 2 A summary of the PICOS elements that comprise the systematic review

Primary care doctors working alone, in group practices and healthcare teams in any country

Any (psychosocial) intervention or combination of interventions developed to improve any element or combination of elements of well-being.

No intervention or usual support and care

Primary: all well-being outcomes related to any of the 20 aspects of well-being identified in Table 1 or combinations thereof including improvement in mental illness, measures of stress, anxiety, depression, addiction and burnout

Randomised controlled trials including cluster randomised trials

Non-randomised controlled trials

Controlled before-and-after trials

Interrupted time series trials

Secondary: physiological outcome measures of improvement in well-being, e.g. cortisol.