Skip to main content

Table 2 Definitions of outcomes in opioid substitution investigations

From: The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol

Outcome Definition Measurement of variable (units) Statistical estimates and measurement of association of this outcome Studies
Continued illicit drug abuse Abstaining from illicit opioid use throughout treatment. -Urine toxicology screening OR, rate ratio [39, 46, 47, 50, 51]
-Self-reported drug use  
Retention in treatment Proportion or participants completing treatment and days in treatment from beginning of the study until the last day of therapy. -Number of days patient remains in treatment (days) Comparing means (SD), HR, adjusted HR using Cox model, rate ratio, Kaplan-Meier estimator [39, 47, 5254]
Adverse events Reaction to drugs and/or change in health status during course of therapy. -Interviews t-test [30, 39, 51, 54]
-Physical examination
-Randomly recorded at visits
-Total number of adverse events per day