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Table 1 Most commonly used therapies for treatment of diabetic neuropathy

From: Pharmacologic interventions for painful diabetic neuropathy: an umbrella systematic review and comparative effectiveness network meta-analysis (Protocol)

Class Medication Minimum effective dose (total daily dose)
Tricyclics Amitriptyline 50 mg
  Desipramine 100 mg
  Imipramine 100 mg
  Nortriptyline 50 mg
Selective serotonin  reuptake inhibitors Duloxetine 60 mg
  Paroxetine 40 mg
  Venlafaxinea 75 mg
Anticonvulsants Carbamazepine 600 mg
  Gabapentin 900 mg
  Lamotriginea 100 mg
  Oxcarbazepinea 600 mg
  Pregabalin 150 mg
  Sodium valproatea 400 mg
  Topiramatea 100 mg
Topical analgesics Capsaicin 0.0075%  
  Doxepina  
  Lidocaine 5% patcha  
  Mexiletinea  
  Pentoxifylinea  
Analgesic opiates Morphinea 15 mg
  Oxycodone 20 mg
  Tapentadola 100 mg
  Tramadol 100 mg
Aldose reductase  inhibitorsa Epalrestat 150 mg
  Ranirestat 20 mg
  Fidarestat 1 mg
  Ponalrestat 600 mg
  Sorbinil 250 mg
Various Lacosamidea 100 mg
  1. aNo dose recommended by the American Diabetes Association.