Skip to main content

Table 1 Most commonly used therapies for treatment of diabetic neuropathy

From: Pharmacologic interventions for painful diabetic neuropathy: an umbrella systematic review and comparative effectiveness network meta-analysis (Protocol)

Class

Medication

Minimum effective dose (total daily dose)

Tricyclics

Amitriptyline

50 mg

 

Desipramine

100 mg

 

Imipramine

100 mg

 

Nortriptyline

50 mg

Selective serotonin  reuptake inhibitors

Duloxetine

60 mg

 

Paroxetine

40 mg

 

Venlafaxinea

75 mg

Anticonvulsants

Carbamazepine

600 mg

 

Gabapentin

900 mg

 

Lamotriginea

100 mg

 

Oxcarbazepinea

600 mg

 

Pregabalin

150 mg

 

Sodium valproatea

400 mg

 

Topiramatea

100 mg

Topical analgesics

Capsaicin 0.0075%

 
 

Doxepina

 
 

Lidocaine 5% patcha

 
 

Mexiletinea

 
 

Pentoxifylinea

 

Analgesic opiates

Morphinea

15 mg

 

Oxycodone

20 mg

 

Tapentadola

100 mg

 

Tramadol

100 mg

Aldose reductase  inhibitorsa

Epalrestat

150 mg

 

Ranirestat

20 mg

 

Fidarestat

1 mg

 

Ponalrestat

600 mg

 

Sorbinil

250 mg

Various

Lacosamidea

100 mg

  1. aNo dose recommended by the American Diabetes Association.