Table 1 Review eligibility criteria
From: A protocol for a systematic review for perioperative pregabalin use
Study characteristic | Inclusion criteria | Exclusion criteria |
|---|---|---|
Patient population | · Adults undergoing elective surgical procedures | · Non-surgical use, such as anti-epileptic, chronic pain, psychiatric conditions, generalized anxiety disorder |
|  |  | · Trauma, burns without surgery |
|  |  | · Other painful medical conditions, such as diabetic peripheral neuropathy, post herpetic neuralgia, fibromyalgia |
Intervention- Treatment | · Oral pregabalin (any dose) administered before and/or after surgery with or without background multimodal analgesia | · Gabapentin |
|  | · Studies of pregabalin in combination with another drug will also be included but excluded in sensitivity analyses |  |
Intervention- Comparison | · Placebo or any specific analgesic (including pregabalin in a different dose or gabapentin) with any route of administration, except sedatives and hypnotics (for example, acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, tricyclic antidepressants) |  |
|  | · Comparators may or may not have been added on to background multimodal analgesia. |  |
Study design | · Randomized controlled trials | · Case studies |
|  |  | · Observational studies |
|  |  | · Retrospective study |
|  |  | · Non-randomized |
|  |  | · Non controlled |
|  |  | · Expert opinion |
Setting | · Inpatient with or without extension to outpatient settings | · Exclusively outpatient |
Timing | · 48 to 24 hours before surgery to 7 days (for acute pain) and up to 6 months postsurgery (for chronic postoperative pain) |  |