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Table 1 Review eligibility criteria

From: A protocol for a systematic review for perioperative pregabalin use

Study characteristic Inclusion criteria Exclusion criteria
Patient population · Adults undergoing elective surgical procedures · Non-surgical use, such as anti-epileptic, chronic pain, psychiatric conditions, generalized anxiety disorder
   · Trauma, burns without surgery
   · Other painful medical conditions, such as diabetic peripheral neuropathy, post herpetic neuralgia, fibromyalgia
Intervention- Treatment · Oral pregabalin (any dose) administered before and/or after surgery with or without background multimodal analgesia · Gabapentin
  · Studies of pregabalin in combination with another drug will also be included but excluded in sensitivity analyses  
Intervention- Comparison · Placebo or any specific analgesic (including pregabalin in a different dose or gabapentin) with any route of administration, except sedatives and hypnotics (for example, acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, tricyclic antidepressants)  
  · Comparators may or may not have been added on to background multimodal analgesia.  
Study design · Randomized controlled trials · Case studies
   · Observational studies
   · Retrospective study
   · Non-randomized
   · Non controlled
   · Expert opinion
Setting · Inpatient with or without extension to outpatient settings · Exclusively outpatient
Timing · 48 to 24 hours before surgery to 7 days (for acute pain) and up to 6 months postsurgery (for chronic postoperative pain)