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Table 1 Characteristics of studies included in systematic review and meta-analysis for protective efficacy against travelers’ diarrhea

From: Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis

Author Country of traveler Country of travel Population Study design Antibiotic evaluated Dose and frequency No. of patientsin allregimens Duration of therapy Protective Efficacy
Studies reviewed and included in meta-analysis
Johnson et al. (1986) [24] USA Mexico Language school R, DB, PC Norfloxacin 400 mg daily 115 14 days 88%*
Wistrom et al. (1987) [31] Sweden Africa, Asia, South America NS R, DB, PC Norfloxacin 200 mg bid 115 5 to 21 days 84%*
Scott et al. (1990) [34] USA/ Italy Egypt Military R, DB, PC Norfloxacin 400 mg daily 222 7 days 93%*
Rademaker et al. (1989) [30] The Netherlands Tunisia Leisure R, DB, PC Ciprofloxacin 500 mg daily 53 8 days 94%*
Heck et al. (1994) [33] USA Central and South America Volunteering R, DB, PC Ciprofloxacin 500 mg daily 278 5 to14 days 85%*
DuPont et al. (2005) [26] USA Mexico Language school R, DB, PC Rifaximin 200 mg daily, bid, tid 210 14 days 73%*,a
Armstrong et al. (2010) [25] USA Turkey Military R, DB, PC Rifaximin 1,100 mg daily 95 14 days 67%
Martinez-Sandoval et al. (2010) [28] USA Mexico Language school R, DB, PC Rifaximin 600 mg daily 201 14 days 68%*
Flores et al. (2011) [27] USA Mexico Language school R, DB, PC Rifaximin 550 mg daily 98 14 days 28%
Other studies of relevance reviewed but not included in meta-analysis
Parry et al. (1994) [29] UK Nepal Himalayan expedition R, DB, PC Ciprofloxacin 250 mg daily 21 28 days NA
Taylor et al. (2006) [32] NA NA Volunteers R, DB, PC Rifaximin 200 mg tid 25 3 days NA
  1. aRifaximin groups combined. Note: Studies are listed in chronological order by an antibiotic studied. bid = twice daily; tid = three times daily; R, DB, PC = randomized, double-blind, placebo-controlled; NA = not available; NS = not specified. *Statistically significant.