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Table 9 Stage 3 or 4 sleep (%) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study
PMID
Baseline AHI (SD)
[eligibility]
Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change
(final)
Net difference
or difference
95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32]
11035671
58 (6)
[≥10]
12.7 (5.3) 2 months
(XO)
APAP 25 44 min (36) 43 -9 min nd NS 0 B
     CPAP 25 44 min (36) 52      
Hussain 2004 [20]
15072173
47 (36)
[> 15]
11.1 (6.4) 1 month
(XO)
APAP 10 14 (25) -4.0 -8 -18.32 to 2.32 nd 0 C
     CPAP 10 14 (25) 4.0      
Konermann 1998 [31]
9515848
38 (14)
[> 20]
nd 3 to 6 months
(PL)
APAP 25 13.2
(12.2)
14 7.8 1.8 to 13.7b < 0.01 4 B
     CPAP 23 11.4
(10.4)
6.2      
Meurice 2007 [13]
17638595
55 (10)
[nd]
11.8 (4.9) 6 months
(PL)
APAP (AutoSet) 15 25.5 (14.7) -4.4 -5.2 -13.51 to 3.11 nd 15 B
     CPAP 14 17.1
(7)
0.8      
Nolan 2007 [14]
17326544
15 (8)
[≥5)
12.3 (4) 2 months
(XO)
APAP 29 13.7 (7.8) 1.3 0.3 -3.29 to 3.89b 0.87 15 B
     CPAP 29 13.7 (7.8) 1.0      
Randerath 2001 [26]
11254519
35 (26)
[≥10]
11.1 (5.1) 1.5 months
(XO)
APAP 52 14 (11) 0 -1 -3.45 to 1.45 NS 12 B
     CPAP 52 14 (11) 1.0      
Resta 2004 [24]
15679008
47 (11)
[> 30]
13.9 (3.2) 1 month
(PL)
APAP 10 19.8 (10.9) 14 7.3 -2.35 to 16.95 nd 0 C
     CPAP 10 22.8
(12.5)
6.7      
Sériès 1997 [27]
9341056
44 (20)
[nd]
15.5 (4.5) 0.75 months
(PL)
APAPc 12 nd ndd - - NS 0 C
     CPAP 12 nd nd      
     APAPe 12 nd ndd - - NS   
     CPAP 12 nd nd      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP; continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dDirections of changes not reported in the study. eMeasured effective pressure.