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Table 9 Stage 3 or 4 sleep (%) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Baseline AHI (SD) [eligibility] Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change (final) Net difference or difference 95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32] 11035671 58 (6) [≥10] 12.7 (5.3) 2 months (XO) APAP 25 44 min (36) 43 -9 min nd NS 0 B
     CPAP 25 44 min (36) 52      
Hussain 2004 [20] 15072173 47 (36) [> 15] 11.1 (6.4) 1 month (XO) APAP 10 14 (25) -4.0 -8 -18.32 to 2.32 nd 0 C
     CPAP 10 14 (25) 4.0      
Konermann 1998 [31] 9515848 38 (14) [> 20] nd 3 to 6 months (PL) APAP 25 13.2 (12.2) 14 7.8 1.8 to 13.7b < 0.01 4 B
     CPAP 23 11.4 (10.4) 6.2      
Meurice 2007 [13] 17638595 55 (10) [nd] 11.8 (4.9) 6 months (PL) APAP (AutoSet) 15 25.5 (14.7) -4.4 -5.2 -13.51 to 3.11 nd 15 B
     CPAP 14 17.1 (7) 0.8      
Nolan 2007 [14] 17326544 15 (8) [≥5) 12.3 (4) 2 months (XO) APAP 29 13.7 (7.8) 1.3 0.3 -3.29 to 3.89b 0.87 15 B
     CPAP 29 13.7 (7.8) 1.0      
Randerath 2001 [26] 11254519 35 (26) [≥10] 11.1 (5.1) 1.5 months (XO) APAP 52 14 (11) 0 -1 -3.45 to 1.45 NS 12 B
     CPAP 52 14 (11) 1.0      
Resta 2004 [24] 15679008 47 (11) [> 30] 13.9 (3.2) 1 month (PL) APAP 10 19.8 (10.9) 14 7.3 -2.35 to 16.95 nd 0 C
     CPAP 10 22.8 (12.5) 6.7      
Sériès 1997 [27] 9341056 44 (20) [nd] 15.5 (4.5) 0.75 months (PL) APAPc 12 nd ndd - - NS 0 C
     CPAP 12 nd nd      
     APAPe 12 nd ndd - - NS   
     CPAP 12 nd nd      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP; continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dDirections of changes not reported in the study. eMeasured effective pressure.