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Table 8 Rapid eye movement sleep (%) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Baseline AHI (SD) [eligibility] Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change (final) Net difference or difference 95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32] 11035671 58 (6) [≥10] 12.7 (5.3) 2 months (XO) APAP 25 16 (5) 5 -1 nd nd 0 B
     CPAP 25 16 (5) 6      
Hussain 2004 [20] 15072173 47 (36) [> 15] 11.1 (6.4) 1 month (XO) APAP 10 15 (7.0) 4.0 -1 -4.72 to 2.72 nd 0 C
     CPAP 10 17.6 (5.1) 2.0      
Konermann 1998 [31] 9515848 38 (14) [> 20] nd 3 to 6 months (PL) APAP 25 8.2 (8.1) 11.9 7.1 nd NS 4 B
     CPAP 23 5.4 (6.0) 4.8      
Meurice 2007 [13] 17638595 55 (10) [nd] 11.8 (4.9) 6 months (PL) APAP (AutoSet) 15 18.9 (6.6) -2.4 -2.9 -7.49 to 1.69 nd 15 B
     CPAP 14 19.1 (5.9) 0.5      
Nolan 2007 [14] 17326544 15 (8) [≥5) 12.3 (4) 2 months (XO) APAP 29 17.6 (5.1) -0.5 -2.5 -5.11 to 0.11b 0.06 15 B
     CPAP 29 17.6 (5.1) 2.0      
Planes 2003 [29] 12683473 59 (17) [≥30] 15.1 (3.9) 2 months (PL) APAP 16 12.4 (7.0) 4.2 0.5 -5.44 to 6.44 nd 14 C
     CPAP 14 13.7 (9.3) 3.7      
Randerath 2001 [26] 11254519 35 (26) [≥10] 11.1 (5.1) 1.5 months (XO) APAP 52 11 (8) 6.0 1 -0.63 to 2.63 nd 12 B
     CPAP 52 11 (8) 5.0      
Resta 2004 [24] 15679008 47 (11) [> 30] 13.9 (3.2) 1 month (PL) APAP 10 15.0 (8.1) 6.7 -2 -10.31 to 6.31 nd 0 C
     CPAP 10 15.9 (4.2) 8.7      
Sériès 1997 [27] 9341056 44 (20) [nd] 15.5 (4.5) 0.75 months (PL) APAPc 12 nd ndd - - NS 0 C
     CPAP 12 nd nd      
     APAPe 12 nd ndd - - NS   
     CPAP 12 nd nd      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dDirections of changes not reported in the study. eMeasured effective pressure.