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Table 8 Rapid eye movement sleep (%) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study
PMID
Baseline AHI (SD)
[eligibility]
Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change
(final)
Net difference
or difference
95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32]
11035671
58 (6)
[≥10]
12.7 (5.3) 2 months
(XO)
APAP 25 16
(5)
5 -1 nd nd 0 B
     CPAP 25 16
(5)
6      
Hussain 2004 [20]
15072173
47 (36)
[> 15]
11.1 (6.4) 1 month
(XO)
APAP 10 15 (7.0) 4.0 -1 -4.72 to 2.72 nd 0 C
     CPAP 10 17.6 (5.1) 2.0      
Konermann 1998 [31]
9515848
38 (14)
[> 20]
nd 3 to 6 months
(PL)
APAP 25 8.2
(8.1)
11.9 7.1 nd NS 4 B
     CPAP 23 5.4
(6.0)
4.8      
Meurice 2007 [13]
17638595
55 (10)
[nd]
11.8 (4.9) 6 months
(PL)
APAP (AutoSet) 15 18.9 (6.6) -2.4 -2.9 -7.49 to 1.69 nd 15 B
     CPAP 14 19.1
(5.9)
0.5      
Nolan 2007 [14]
17326544
15 (8)
[≥5)
12.3 (4) 2 months
(XO)
APAP 29 17.6 (5.1) -0.5 -2.5 -5.11 to 0.11b 0.06 15 B
     CPAP 29 17.6 (5.1) 2.0      
Planes 2003 [29]
12683473
59 (17)
[≥30]
15.1 (3.9) 2 months
(PL)
APAP 16 12.4
(7.0)
4.2 0.5 -5.44 to 6.44 nd 14 C
     CPAP 14 13.7 (9.3) 3.7      
Randerath 2001 [26]
11254519
35 (26)
[≥10]
11.1 (5.1) 1.5 months
(XO)
APAP 52 11 (8) 6.0 1 -0.63 to 2.63 nd 12 B
     CPAP 52 11 (8) 5.0      
Resta 2004 [24]
15679008
47 (11)
[> 30]
13.9 (3.2) 1 month
(PL)
APAP 10 15.0
(8.1)
6.7 -2 -10.31 to 6.31 nd 0 C
     CPAP 10 15.9 (4.2) 8.7      
Sériès 1997 [27]
9341056
44 (20)
[nd]
15.5 (4.5) 0.75 months
(PL)
APAPc 12 nd ndd - - NS 0 C
     CPAP 12 nd nd      
     APAPe 12 nd ndd - - NS   
     CPAP 12 nd nd      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dDirections of changes not reported in the study. eMeasured effective pressure.