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Table 5 Arousal index (events/hour) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Baseline AHI (SD) [eligibility] Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change (final) Net difference or difference 95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32] 11035671 58 (6) [≥10] 12.7 (5.3) 2 months (XO) APAP 25 45.6 (25.8) -30.1 1.8 nd NS 0 B
     CPAP 25 45.6 (25.8) -31.9      
Damjanovic 2009 [10] 19129293 44 (25) [≥15] 8.8 (5.18) 3 months (PL) APAP 46 30.6 (22.4) -18.3 -0.2 -7.92 to 7.52 nd 8 B
     CPAP 46 34.5 (21.0) -18.1      
    9 months (PL) APAP 34 30.6 (22.4) -17.7 3.6 -4.09 to 11.29 nd 22  
     CPAP 44 34.5 (21.0) -21.3      
Galetke 2008 [12] 17148931 33 (19) [> 10] 10.3 (5.7) 2 months (XO) APAP 20 17.6 (9.2) -4.0 1.0 -2.52 to 4.52 nd nd C
     CPAP 20 17.6 (9.2) -5.0      
Hussain 2004 [20] 15072173 47 (36) [> 15] 11.1 (6.4) 1 month (XO) APAP 10 17.3 (17.7) -11.4 1.0 -2.5 to 4.5 nd 0 C
     CPAP 10 17.3 (17.7) -12.4      
Konermann 1998 [31] 9515848 38 (14) [> 20} nd 3 to 6 months (PL) APAP 25 16.9 (10.5) -9.5 -3.3 -6.6 to 0b < 0.05 4 B
     CPAP 23 13.3 (13.3) -6.2      
Nolan 2007 [14] 17326544 15 (8) [≥5) 12.3 (4) 2 months (XO) APAP 29 16.0 (14.0) -14.0 -3.0 -5.7 to -0.29b 0.03 15 B
     CPAP 29 16.0 (14.0) -11.0      
Planes 2003 [29] 12683473 59 (17) [≥30] 15.1 (3.9) 2 months (PL) APAP 16 44.4 (19.1)   3.3 -7.14 to 12.74 nd 14 C
     CPAP 14 48.5 (14.2)       
Randerath 2001 [26] 11254519 35 (26) [≥10] 11.1 (5.1) 1.5 months (XO) APAP 52 34 (21.7) -23.1 -1.7 -3.7 to 0.3 nd 12 B
     CPAP 52 34 (21.7) -21.4      
Resta 2004 [24] 15679008 47 (11) [> 30] 13.9 (3.2) 1 month (PL) APAP 10 43.1 (11.9) -35.7 0.1 -8.29 to 8.49 nd 0 C
     CPAP 10 43.1 (9.1) -35.8      
Sériès 1997 [27] 9341056 44 (20) [nd] 15.5 (4.5) 0.75 months (PL) APAPc 12 nd nd - - NS 0 C
     CPAP 12 nd nd      
     APAPd 12 nd nd - - NS   
     CPAP 12 nd nd      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dMeasured effective pressure.