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  1. Commentary

    Approaches to interpreting and choosing the best treatments in network meta-analyses

    When randomized trials have addressed multiple interventions for the same health problem, network meta-analyses (NMAs) permit researchers to statistically pool data from individual studies including evidence f...

    L. Mbuagbaw, B. Rochwerg, R. Jaeschke, D. Heels-Andsell, W. Alhazzani, L. Thabane and Gordon H. Guyatt

    Systematic Reviews 2017 6:79

    Published on: 12 April 2017

  2. Protocol

    Therapeutic interventions for alcohol dependence in non-inpatient settings: a systematic review and network meta-analysis (protocol)

    Alcohol dependence is common and serious cause of social and physical harm. However, the optimal management of those with moderate and severe alcohol dependence in primary and community care after detoxificati...

    Hung-Yuan Cheng, Roy G. Elbers, Julian P. T. Higgins, Abigail Taylor, Georgina J. MacArthur, Luke McGuinness, Sarah Dawson, José A. López-López, Sean Cowlishaw, Matthew Hickman and David Kessler

    Systematic Reviews 2017 6:77

    Published on: 11 April 2017

  3. Protocol

    Inter-pregnancy interval and pregnancy outcomes among women with delayed childbearing: protocol for a systematic review

    Women in high resource nations are increasingly delaying childbearing until their thirties. Delayed childbearing poses challenges for the spacing of a woman’s pregnancies. Inter-pregnancy intervals <12 months ...

    Mani Asgharpour, Sofia Villarreal, Laura Schummers, Jennifer Hutcheon, Dorothy Shaw and Wendy V. Norman

    Systematic Reviews 2017 6:75

    Published on: 8 April 2017

  4. Protocol

    Epidemiology and reporting characteristics of overviews of reviews of healthcare interventions published 2012–2016: protocol for a systematic review

    Overviews of systematic reviews (overviews) attempt to systematically retrieve and summarize the results of multiple systematic reviews (SRs) for a given condition or public health problem. Two prior descripti...

    Dawid Pieper, Michelle Pollock, Ricardo M. Fernandes, Roland Brian Büchter and Lisa Hartling

    Systematic Reviews 2017 6:73

    Published on: 7 April 2017

  5. Protocol

    Digoxin versus placebo, no intervention, or other medical interventions for atrial fibrillation and atrial flutter: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis

    Atrial fibrillation is the most common arrhythmia of the heart with a prevalence of approximately 2% in the western world. Atrial flutter, another arrhythmia, occurs less often with an incidence of approximate...

    Naqash J. Sethi, Sanam Safi, Joshua Feinberg, Emil E. Nielsen, Christian Gluud and Janus C. Jakobsen

    Systematic Reviews 2017 6:71

    Published on: 5 April 2017

  6. Protocol

    Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

    The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from ca...

    Ferrán Catalá-López, Brian Hutton, Jane A. Driver, Matthew J. Page, Manuel Ridao, José M. Valderas, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Salvador Martínez, Ricard Gènova-Maleras, Diego Macías-Saint-Gerons, Benedicto Crespo-Facorro, Eduard Vieta, Alfonso Valencia and Rafael Tabarés-Seisdedos

    Systematic Reviews 2017 6:69

    Published on: 4 April 2017

  7. Protocol

    Epidemiology of chronic obstructive pulmonary disease in the global HIV-infected population: a systematic review and meta-analysis protocol

    Evidence suggests a relationship between human immunodeficiency virus (HIV) infection and chronic obstructive pulmonary disease (COPD). Although the high burden of COPD and the HIV disease is clearly demonstra...

    Jean Joel R. Bigna, Angeladine Malaha Kenne and Serra Lem Asangbeh

    Systematic Reviews 2017 6:68

    Published on: 29 March 2017

  8. Protocol

    Variables associated with unplanned general adult ICU admission in hospitalised patients: protocol for a systematic review

    Failure to promptly identify deterioration in hospitalised patients is associated with delayed admission to intensive care units (ICUs) and poor outcomes. Existing vital sign-based Early Warning Score (EWS) al...

    James Malycha, Tim Bonnici, Katarina Sebekova, Tatjana Petrinic, Duncan Young and Peter Watkinson

    Systematic Reviews 2017 6:67

    Published on: 28 March 2017

  9. Protocol

    The effectiveness of health care provider physical activity recommendations in cancer survivors: a systematic review and meta-analysis protocol

    Cancer survivors face a range of negative physical and psychological effects that can be mitigated by participating in physical activity. Despite this, most do not meet recommended levels. Health care provider...

    Jennifer Brunet, Amanda Wurz, Connor O’Rielly, Doris Howell, Mathieu Bélanger and Jonathan Sussman

    Systematic Reviews 2017 6:66

    Published on: 27 March 2017

  10. Research

    The risk associated with spinal manipulation: an overview of reviews

    Spinal manipulative therapy (SMT) is a widely used manual treatment, but many reviews exist with conflicting conclusions about the safety of SMT. We performed an overview of reviews to elucidate and quantify t...

    Sabrina Mai Nielsen, Simon Tarp, Robin Christensen, Henning Bliddal, Louise Klokker and Marius Henriksen

    Systematic Reviews 2017 6:64

    Published on: 24 March 2017

  11. Protocol

    An evaluation of the comparative effectiveness of geriatrician-led comprehensive geriatric assessment for improving patient and healthcare system outcomes for older adults: a protocol for a systematic review and network meta-analysis

    Comprehensive geriatric assessment (CGA) is an integrated model of care involving a geriatrician and an interdisciplinary team and can prioritize and manage complex health needs of older adults with multimorbi...

    Charlene Soobiah, Caitlin Daly, Erik Blondal, Joycelyne Ewusie, Joanne Ho, Meghan J. Elliott, Rossini Yue, Jayna Holroyd-Leduc, Barbara Liu, Sharon Marr, Jenny Basran, Andrea C. Tricco, Jemila Hamid and Sharon E. Straus

    Systematic Reviews 2017 6:65

    Published on: 24 March 2017

  12. Research

    Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis

    A rigorous systematic review and meta-analysis focused on randomised controlled trials (RCTs) of non-individualised homeopathic treatment has not previously been reported. We tested the null hypothesis that th...

    Robert T. Mathie, Nitish Ramparsad, Lynn A. Legg, Jürgen Clausen, Sian Moss, Jonathan R. T. Davidson, Claudia-Martina Messow and Alex McConnachie

    Systematic Reviews 2017 6:63

    Published on: 24 March 2017

  13. Research

    Convergent and sequential synthesis designs: implications for conducting and reporting systematic reviews of qualitative and quantitative evidence

    Systematic reviews of qualitative and quantitative evidence can provide a rich understanding of complex phenomena. This type of review is increasingly popular, has been used to provide a landscape of existing ...

    Quan Nha Hong, Pierre Pluye, Mathieu Bujold and Maggy Wassef

    Systematic Reviews 2017 6:61

    Published on: 23 March 2017

  14. Protocol

    Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism—protocol for a systematic review

    Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adve...

    Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce and Scott Wilkes

    Systematic Reviews 2017 6:60

    Published on: 21 March 2017

  15. Protocol

    Economic evaluation of interventions delivered by primary care providers to improve neurodevelopment in children aged under 5 years: protocol for a scoping review

    Frequently cited benefit-cost ratios suggest that interventions to improve neurodevelopment have high economic returns when implemented during pregnancy and early childhood. However, there are many challenges ...

    Karen M. Edmond, Natalie A. Strobel, Kimberley McAuley, Elizabeth Geelhoed and Lisa Hurt

    Systematic Reviews 2017 6:59

    Published on: 21 March 2017

  16. Protocol

    Impact of different dietary approaches on glycemic control and cardiovascular risk factors in patients with type 2 diabetes: a protocol for a systematic review and network meta-analysis

    Dietary advice is one of the cornerstones in the management of type 2 diabetes mellitus. The American Diabetes Association recommended a hypocaloric diet for overweight or obese adults with type 2 diabetes in ...

    Lukas Schwingshackl, Anna Chaimani, Georg Hoffmann, Carolina Schwedhelm and Heiner Boeing

    Systematic Reviews 2017 6:57

    Published on: 20 March 2017

  17. Methodology

    Five shared decision-making tools in 5 months: use of rapid reviews to develop decision boxes for seniors living with dementia and their caregivers

    Decision support tools build upon comprehensive and timely syntheses of literature. Rapid reviews may allow supporting their development by omitting certain components of traditional systematic reviews. We thu...

    Moulikatou Adouni Lawani, Béatriz Valéra, Émilie Fortier-Brochu, France Légaré, Pierre-Hugues Carmichael, Luc Côté, Philippe Voyer, Edeltraut Kröger, Holly Witteman, Charo Rodriguez and Anik M. C. Giguere

    Systematic Reviews 2017 6:56

    Published on: 15 March 2017

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