Table 2 Summary of study design and outcomes of included studies

Andrews et al. [77]

Cohort—retrospective

Healed at 3 and 12 months

Boutoille et al. [38]

Case control

Medical Outcome Study Short Form 36 (MOS SF-36)

Brown et al. [17]

Cohort—retrospective

Volpicelli ambulatory scale

Mortality at 1, 3, 5 years

Czerniecki et al. [76]

Cohort—prospective

Locomotor capabilities index 5

Czerniecki et al. [34]

Cohort—prospective

Locomotor capabilities index 5

Dillingham and Pezzin [66]

Cohort—retrospective

Reamputation at 1 year

Mortality at 1 year

Dillingham et al. [28]

Cohort—retrospective

Mortality at 1 year

Evans et al. [18]

Cohort—retrospective

Healed at 1 year

Reamputation at 1 year

Mortality at 2 years

Glaser et al. [65]

Cohort—retrospective

Reamputation at 1 and 5 years

Mortality at 1, 3, 5 years

Griffin et al. [59]

Cohort—retrospective

Mortality at 30 days and 1 year

Hambleton et al. [63]

Case control

Mortality at 3 and 6 months and 1 and 5 years

Izumi et al. [27, 67]

Cohort—retrospective

Reamputation at 1, 3, 5 years

Mortality at 10 months and 5 years

Jindeel and Narahara [68]

Cohort—retrospective

Mortality at 1 and 5 years

Jones and Marshall [69]

Cohort—retrospective

Mortality at 3 and 5 years

Kono and Muder [70]

Cohort—retrospective

Reamputation at 6 months and 3 year

Mortality at 3 years

Kristensen et al. [61]

Cohort—retrospective

Mortality at 30 days and 1 year

Lakstein et al. [64]

Cohort—retrospective

Healed at 3 weeks

Reamputation at 4 weeks

Marzen-Groller et al. [75]

Cohort^a

Modified functional independence measure

Mayfield et al. [71]

Cohort—retrospective

Mortality at 30 days and 5 years

Norvell et al. [33]

Cohort—prospective

Locomotor capabilities index 5

Peters et al. [35]

Cohort—retrospective

Sickness impact profile

Sickness impact profile

Quigley et al. [36]

Cross-sectional

Medical Outcome Study Short Form 36 (MOS SF-36 version 2)

Sandnes et al. [72]

Cohort—retrospective

Mortality at 30 days, 1 and 5 years

Sheahan et al. [73]

Cohort—retrospective

Mortality at 30 days, 1 and 5 years

Stone et al. [74]

Cohort—retrospective

Healed at 3 months

Mortality at 60 days, 1, 3 and 5 years

Vamos et al. [60]

Cohort—retrospective

Mortality at 30 days and 1 year

Winell et al. [62]

Cross-sectional

Mortality at 2 years

Younger et al. [58]

Case control

Reamputation at 1 year