Data extraction category | Specific information to extract |
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Study characteristics | Author(s); year of publication, study design (randomized controlled trial or prospective cohort). |
Characteristics of animal model | Species; strain; gender; total number of animals; number of animals in each experimental cohort; number of animals excluded; age (in total and per experimental cohort); weight (in total and per experimental cohort); and physiological characteristics reported by the authors at baseline before application of interventions (in total and per experimental cohort). |
Details of injury induced in animals | Specifics of the injury that was induced; mechanism of producing the injury model (as described by authors); anatomical location of the injury or injuries (e.g., polytrauma model vs. single/more localized type of injury); and injury severity (e.g., specific grade of liver injury). |
Details of treatment employed | Whether an entire damage control paradigm or an individual intervention or adjunct was tested; the specific treatment that was evaluated; and the definition of damage control surgery. Additional details collected are based on a modified version of the elements of experimental procedures outlined in the Animal Research: Reporting In Vivo Experiments (ARRIVE) guidelines: how, when, where, and why[66]: How? Specific method of employment of treatment tested and how long it was applied for. When? How long after injury was induced was the intervention(s)/adjunct(s) implemented? Where? Laboratory setting, surgical theater, or alternate setting as described by author(s). Why? To evaluate the purpose of testing the treatment. |
Consequences of damage control surgery and/or definitive surgery to animals | Mortality; changes in post-injury physiological parameters, including estimated volumes and/or rates of blood loss, laboratory surrogates of blood loss (complete blood counts, hemoglobin concentrations, and/or hematocrits); and several physiologic measurements, including blood pressures (mean arterial (MAP), systolic, and diastolic), heart rates, urinary outputs, and core body temperatures, and arterial lactate, base deficit/excess, and pH values, prothrombin and partial thromboplastin times, international normalized ratios, and thromboelastography (TEG) results/activated clotting times. |