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  1. Chronic kidney disease-mineral and bone disorders (CKD-MBD) have been associated with poor health outcomes, including diminished quality and length of life. Standard management for CKD-MBD includes phosphate-r...

    Authors: Nigar Sekercioglu, Jason W. Busse, Reem A. Mustafa, Gordon H. Guyatt and Lehana Thabane
    Citation: Systematic Reviews 2016 5:2
  2. Research with a focus on Aboriginal and Torres Strait Islander Australian’s (hereafter referred to as Indigenous1) needs is crucial to ensure culturally appropriate evidence-based strategies are developed to impr...

    Authors: Sara Farnbach, Anne-Marie Eades and Maree Lisa Hackett
    Citation: Systematic Reviews 2015 4:189
  3. Up to 90 % of people with scleroderma have gastrointestinal (GI) problems such as constipation, bloating, diarrhea, and malabsorption. These problems significantly impair quality of life. Our objective was to ...

    Authors: Brian Younho Hong, Raymond Giang, Lawrence Mbuagbaw, Maggie Larche and Lehana Thabane
    Citation: Systematic Reviews 2015 4:188
  4. Suicidal behaviour is a complex phenomenon with a multitude of risk factors. Brain-derived neurotrophic factor (BDNF), a protein crucial to nervous system function, may be involved in suicide risk. The objecti...

    Authors: Rebecca B. Eisen, Stefan Perera, Laura Banfield, Rebecca Anglin, Luciano Minuzzi and Zainab Samaan
    Citation: Systematic Reviews 2015 4:187
  5. The mental health of children and adolescents is a key area of health concern internationally. Previous empirical studies suggest that resilience may act as a protective mechanism towards the development of me...

    Authors: Julia Dray, Jenny Bowman, Luke Wolfenden, Elizabeth Campbell, Megan Freund, Rebecca Hodder and John Wiggers
    Citation: Systematic Reviews 2015 4:186
  6. The long-term management of chronic diseases requires adoption of complex dietary recommendations, which can be facilitated by regular coaching to support sustained behaviour change. Telehealth interventions c...

    Authors: Jaimon T. Kelly, Dianne P. Reidlinger, Tammy C. Hoffmann and Katrina L. Campbell
    Citation: Systematic Reviews 2015 4:185
  7. Tobacco and alcohol are recognised as the major risk factors for both oral cavity (mouth) and oropharyngeal (throat) cancers, with increasing acceptance of the role of human papillomavirus (HPV) in the aetiolo...

    Authors: Sweta Mathur, David I. Conway, Heather Worlledge-Andrew, Lorna M.D. Macpherson and Alastair J. Ross
    Citation: Systematic Reviews 2015 4:184
  8. Testicular cancer is primarily treated with the surgical removal of the affected testis. About 50 % of testicular cancer patients present with a stage I seminoma. If no chemo- or radiotherapy as adjuvant treat...

    Authors: Frank Kunath, Annabel Spek, Katrin Jensen, Friedemann Zengerling and Stefanie Schmidt
    Citation: Systematic Reviews 2015 4:182
  9. Improving health-care outcomes for people living with dementia when they are admitted to hospital is a policy priority. Dementia friendly interventions in health care promote inclusion of patients and carers i...

    Authors: Melanie Handley, Frances Bunn and Claire Goodman
    Citation: Systematic Reviews 2015 4:180
  10. Whilst nutrition is vital to survival in health, the precise role of nutrition during critical illness is controversial. More specifically, the exact amount of energy that is required during critical illness t...

    Authors: Emma J. Ridley, Andrew R. Davies, Carol Hodgson, Adam Deane, Michael Bailey and D. James Cooper
    Citation: Systematic Reviews 2015 4:179
  11. A physically active lifestyle plays a preventative role in the development of various chronic diseases and mental health conditions. Unfortunately, few adults achieve the minimum amount of physical activity an...

    Authors: Christina C. Loitz, Robert J. Potter, Jessica L. Walker, Nicole C. McLeod and Nora J. Johnston
    Citation: Systematic Reviews 2015 4:178
  12. The risk of developing cardiovascular disease is directly correlated to one’s resting blood pressure (BP), age, and biological sex. Resting BP can be reduced using handgrip exercise training, but the impact of...

    Authors: Danielle C. Bentley, Cindy H. Nguyen and Scott G. Thomas
    Citation: Systematic Reviews 2015 4:176
  13. Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other...

    Authors: Rosemary J. Chakiath, Philip J. Siddall, John E. Kellow, Julia M. Hush, Mike P. Jones, Anna Marcuzzi and Paul J. Wrigley
    Citation: Systematic Reviews 2015 4:175
  14. Fatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. Some evidence has been reported for interventions for fatigue during active treatment. However, to date, the...

    Authors: Teresa Corbett, Declan Devane, Jane C. Walsh, AnnMarie Groarke and Brian E. McGuire
    Citation: Systematic Reviews 2015 4:174
  15. Helping people make well-informed decisions about dysvascular partial foot amputation is becoming increasingly important as improvements in diabetes care and vascular surgery make more distal amputations incre...

    Authors: Michael P Dillon, Stefania Fatone and Matthew Quigley
    Citation: Systematic Reviews 2015 4:173

    The Erratum to this article has been published in Systematic Reviews 2016 5:1

  16. The recent Ebola epidemic in western Africa developed into an acute public health emergency of unprecedented level in modern times. The treatment provided in most cases has been limited to supportive care, as ...

    Authors: Hussein Sweiti, Obinna Ekwunife, Thomas Jaschinski and Stefan K. Lhachimi
    Citation: Systematic Reviews 2015 4:171
  17. Probiotics may prevent antibiotic-associated and Clostridium difficile-associated diarrhoea (AAD/CDAD). Many spinal cord injury centre (SCIC) practitioners consider probiotics generically and may not realise that...

    Authors: Samford Wong, Ali Jamous, Jean O’Driscoll, Ravi Sekhar, Mofid Saif, Steve O’Driscoll, Sarah Lewis, Eamonn McKeown and Shashi P. Hirani
    Citation: Systematic Reviews 2015 4:170
  18. The objective of the study is to conduct a systematic review to compare the effects of high-dose chemotherapy (HDCT) with autologous haematopoietic stem cell transplantation (HSCT) versus standard-dose chemoth...

    Authors: Caroline Main, Jayne S. Wilson, Simon P. Stevens, Aimee E. Houlton, Martin English, Pamela R. Kearns, Bob Phillips, Barry Pizer, Sophie Wilne and Keith Wheatley
    Citation: Systematic Reviews 2015 4:168
  19. Transplantation improves survival and the quality of life of patients with end-stage organ failure. Infection, due to surgical issues, host factors such as diabetes, immunosuppression, and hypogammaglobulinemi...

    Authors: Juthaporn Cowan, Brian Hutton, Nicholas Fergusson, Alexandria Bennett, Jason Tay, D. William Cameron and Greg A. Knoll
    Citation: Systematic Reviews 2015 4:167
  20. Several options are available for the treatment of chronic rhinosinusitis (CRS), but disease control remains elusive for many patients. Recently, literature has emerged describing anti-IgE monoclonal antibody ...

    Authors: Chris J. Hong, Adrian C. Tsang, Jason G. Quinn, James P. Bonaparte, Adrienne Stevens and Shaun J. Kilty
    Citation: Systematic Reviews 2015 4:166
  21. Head injury represents an extremely common presentation to emergency departments (ED), but not all patients present immediately after injury. There is evidence that clinical deterioration following head injury...

    Authors: Carl Marincowitz, Christopher M. Smith and William Townend
    Citation: Systematic Reviews 2015 4:165
  22. Cardiovascular diseases (CVDs), including myocardial infarction, heart failure, peripheral arterial disease and strokes, are highly prevalent conditions and are associated with high morbidity and mortality. Ca...

    Authors: Neil Heron, Frank Kee, Michael Donnelly, Mark A. Tully and Margaret E. Cupples
    Citation: Systematic Reviews 2015 4:164
  23. Many randomised trials have count outcomes, such as the number of falls or the number of asthma exacerbations. These outcomes have been treated as counts, continuous outcomes or dichotomised and analysed using...

    Authors: Peter Herbison, M. Clare Robertson and Joanne E. McKenzie
    Citation: Systematic Reviews 2015 4:163
  24. Fluid administration to critically ill patients remains the subject of considerable controversy. While intravenous fluid given for resuscitation may be life-saving, a positive fluid balance over time is associ...

    Authors: Jonathan A. Silversides, Andrew J. Ferguson, Daniel F. McAuley, Bronagh Blackwood, John C. Marshall and Eddy Fan
    Citation: Systematic Reviews 2015 4:162
  25. Non-union of fractured bone is a major cause of morbidity in the orthopaedic population. Despite this, optimal management of non-union is still unclear and remains a significant clinical challenge. Research co...

    Authors: Sarah K. Stewart, Philippa M. Bennett, Sarah A. Stapley, Janine Dretzke, Danai Bem and Jowan G. Penn-Barwell
    Citation: Systematic Reviews 2015 4:161
  26. Healthcare consumers, researchers, patients and policy makers increasingly use systematic reviews (SRs) to aid their decision-making process. However, the conduct of SRs can be a time-consuming and resource-in...

    Authors: Alexander Tsertsvadze, Yen-Fu Chen, David Moher, Paul Sutcliffe and Noel McCarthy
    Citation: Systematic Reviews 2015 4:160
  27. Landmark studies in adult-onset type 1 diabetes (T1D) populations indicate that improved glycaemic control through use of intensive insulin therapy is strongly associated with reduced risk for the development ...

    Authors: Veena Mazarello Paes, Dimitrios Charalampopoulos, Amal R. Khanolkar, David Taylor-Robinson, Russell Viner, Julie Edge, Terence Stephenson and Rakesh Amin
    Citation: Systematic Reviews 2015 4:159
  28. The matching of critical care service supply with demand is fundamental for the efficient delivery of advanced life support to patients in urgent need. Mismatch in this supply/demand relationship contributes t...

    Authors: S. Abolfazi Soltani, Armann Ingolfsson, David A. Zygun, Henry T. Stelfox, Lisa Hartling, Robin Featherstone, Dawn Opgenorth and Sean M. Bagshaw
    Citation: Systematic Reviews 2015 4:158
  29. Smoking cessation before surgery reduces postoperative complications, and the benefit is positively associated with the duration of being abstinent before a surgical procedure. A key issue in providing preoper...

    Authors: Fujian Song, Tracey J. Brown, Annie Blyth, Vivienne Maskrey, Iain McNamara and Simon Donell
    Citation: Systematic Reviews 2015 4:157
  30. The reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework was developed to determine potential public health impact of interventions (i.e., programs, policy, and practice). The pur...

    Authors: Samantha M. Harden, Bridget Gaglio, Jo Ann Shoup, Kimberlee A. Kinney, Sallie Beth Johnson, Fabiana Brito, Kacie C. A. Blackman, Jamie M. Zoellner, Jennie L. Hill, Fabio A. Almeida, Russell E. Glasgow and Paul A. Estabrooks
    Citation: Systematic Reviews 2015 4:155
  31. Nebulised dornase alfa is used off-label in critically ill patients. We aimed to assess the benefits and harms of nebulised dornase alfa versus placebo, no prophylaxis, or hypertonic saline on patient-importan...

    Authors: Casper Claudius, Anders Perner and Morten Hylander Møller
    Citation: Systematic Reviews 2015 4:153
  32. Current health and social care systems are providing suboptimal and fragmented care to the growing dementia population. Interventions aiming to coordinate care services for individuals with dementia and their ...

    Authors: Amy Backhouse, Chris Dickens, David Richards and Rose McCabe
    Citation: Systematic Reviews 2015 4:156
  33. Though often used to control outbreaks, the efficacy of ward closure is unclear. This systematic review sought to identify studies defining and describing ward closure in outbreak control and to determine impa...

    Authors: Holly Wong, Katherine Eso, Ada Ip, Jessica Jones, Yoojin Kwon, Susan Powelson, Jill de Grood, Rose Geransar, Maria Santana, A. Mark Joffe, Geoffrey Taylor, Bayan Missaghi, Craig Pearce, William A. Ghali and John Conly
    Citation: Systematic Reviews 2015 4:152
  34. Management and choice of sedation is important during critical illness in order to reduce patient suffering and to facilitate the delivery of care. Unfortunately, medications traditionally used for sedation in...

    Authors: Gennie Jing Wang, Emilie Belley-Coté, Lisa Burry, Mark Duffett, Timothy Karachi, Dan Perri, Waleed Alhazzani, Frederick D’Aragon, Hannah Wunsch and Bram Rochwerg
    Citation: Systematic Reviews 2015 4:154
  35. Sepsis from burn injuries can result from colonisation of burn wounds, especially in large surface area burns. Reducing bacterial infection will reduce morbidity and mortality, and mortality for severe burns c...

    Authors: Johnny Kwei, Fenella D. Halstead, Janine Dretzke, Beryl A. Oppenheim and Naiem S. Moiemen
    Citation: Systematic Reviews 2015 4:150
  36. Traumatic brain injury (TBI) is a leading cause of death and disability around the world. Management based on Brain Trauma Foundation (BTF) guidelines is widely accepted and thought to improve outcome. The obj...

    Authors: Yahya H Khormi, Ibrahim Gosadi, Sandra Campbell, Ambikaipakan Senthilselvan, Cian O’kelly and David Zygun
    Citation: Systematic Reviews 2015 4:149
  37. Network meta-analysis is increasingly used to allow comparison of multiple treatment alternatives simultaneously, some of which may not have been compared directly in primary research studies. The majority of ...

    Authors: Chris Cameron, Bruce Fireman, Brian Hutton, Tammy Clifford, Doug Coyle, George Wells, Colin R. Dormuth, Robert Platt and Sengwee Toh
    Citation: Systematic Reviews 2015 4:147
  38. Meeting the needs of the growing number of older people is a challenge for health and social care services. Home-based interventions aiming to modify health-related behaviours of frail older people have the po...

    Authors: Ana Jovicic, Benjamin Gardner, Celia Belk, Kalpa Kharicha, Steve Iliffe, Jill Manthorpe, Claire Goodman, Vari Drennan and Kate Walters
    Citation: Systematic Reviews 2015 4:151
  39. Patient and public involvement in diabetes research is now actively encouraged in different countries because it is believed that involving people with experience of the condition will improve the quality and ...

    Authors: Janet Harris, Marit Graue, Trisha Dunning, Johannes Haltbakk, Gunhild Austrheim, Nina Skille, Berit Rokne and Marit Kirkevold
    Citation: Systematic Reviews 2015 4:146
  40. A significant proportion of women exceeds or does not meet the Institute of Medicine’s gestational weight gain (GWG) guidelines. Inadequate, excessive GWG or weight loss during pregnancy is associated with an ...

    Authors: Taru Manyanga, Danilo F. da Silva, Zachary M. Ferraro, Alysha L. J. Harvey, Shanna Wilson, Holly N. Ockenden and Kristi B. Adamo
    Citation: Systematic Reviews 2015 4:145
  41. Despite recent improvements, uptake and retention of mothers and infants in prevention of mother-to-child transmission (PMTCT) services remain well below target levels in many low- and middle-income countries ...

    Authors: Lisa M. Puchalski Ritchie, Monique van Lettow, Mina C. Hosseinipour, Nora E. Rosenberg, Sam Phiri, Megan Landes, Fabian Cataldo and Sharon E. Straus
    Citation: Systematic Reviews 2015 4:144
  42. Systematic reviews should provide trustworthy guidance to decision-makers, but their credibility is challenged by the selective reporting of trial results and outcomes. Some trials are not published, and even ...

    Authors: Evan Mayo-Wilson, Susan Hutfless, Tianjing Li, Gillian Gresham, Nicole Fusco, Jeffrey Ehmsen, James Heyward, Swaroop Vedula, Diana Lock, Jennifer Haythornthwaite, Jennifer L. Payne, Theresa Cowley, Elizabeth Tolbert, Lori Rosman, Claire Twose, Elizabeth A. Stuart…
    Citation: Systematic Reviews 2015 4:143

    The Correction to this article has been published in Systematic Reviews 2018 7:48

  43. Several stigma reduction intervention strategies have been developed and tested for effectiveness in terms of increasing human immunodeficiency virus (HIV) test uptake. These strategies have been more effectiv...

    Authors: Subash Thapa, Karin Hannes, Margaret Cargo, Anne Buve and Catharina Mathei
    Citation: Systematic Reviews 2015 4:142

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