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  1. The objective of the study is to conduct a systematic review to compare the effects of high-dose chemotherapy (HDCT) with autologous haematopoietic stem cell transplantation (HSCT) versus standard-dose chemoth...

    Authors: Caroline Main, Jayne S. Wilson, Simon P. Stevens, Aimee E. Houlton, Martin English, Pamela R. Kearns, Bob Phillips, Barry Pizer, Sophie Wilne and Keith Wheatley

    Citation: Systematic Reviews 2015 4:168

    Content type: Protocol

    Published on:

  2. Transplantation improves survival and the quality of life of patients with end-stage organ failure. Infection, due to surgical issues, host factors such as diabetes, immunosuppression, and hypogammaglobulinemi...

    Authors: Juthaporn Cowan, Brian Hutton, Nicholas Fergusson, Alexandria Bennett, Jason Tay, D. William Cameron and Greg A. Knoll

    Citation: Systematic Reviews 2015 4:167

    Content type: Protocol

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  3. Several options are available for the treatment of chronic rhinosinusitis (CRS), but disease control remains elusive for many patients. Recently, literature has emerged describing anti-IgE monoclonal antibody ...

    Authors: Chris J. Hong, Adrian C. Tsang, Jason G. Quinn, James P. Bonaparte, Adrienne Stevens and Shaun J. Kilty

    Citation: Systematic Reviews 2015 4:166

    Content type: Research

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  4. Head injury represents an extremely common presentation to emergency departments (ED), but not all patients present immediately after injury. There is evidence that clinical deterioration following head injury...

    Authors: Carl Marincowitz, Christopher M. Smith and William Townend

    Citation: Systematic Reviews 2015 4:165

    Content type: Research

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  5. Cardiovascular diseases (CVDs), including myocardial infarction, heart failure, peripheral arterial disease and strokes, are highly prevalent conditions and are associated with high morbidity and mortality. Ca...

    Authors: Neil Heron, Frank Kee, Michael Donnelly, Mark A. Tully and Margaret E. Cupples

    Citation: Systematic Reviews 2015 4:164

    Content type: Protocol

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  6. Many randomised trials have count outcomes, such as the number of falls or the number of asthma exacerbations. These outcomes have been treated as counts, continuous outcomes or dichotomised and analysed using...

    Authors: Peter Herbison, M. Clare Robertson and Joanne E. McKenzie

    Citation: Systematic Reviews 2015 4:163

    Content type: Research

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  7. Fluid administration to critically ill patients remains the subject of considerable controversy. While intravenous fluid given for resuscitation may be life-saving, a positive fluid balance over time is associ...

    Authors: Jonathan A. Silversides, Andrew J. Ferguson, Daniel F. McAuley, Bronagh Blackwood, John C. Marshall and Eddy Fan

    Citation: Systematic Reviews 2015 4:162

    Content type: Protocol

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  8. Non-union of fractured bone is a major cause of morbidity in the orthopaedic population. Despite this, optimal management of non-union is still unclear and remains a significant clinical challenge. Research co...

    Authors: Sarah K. Stewart, Philippa M. Bennett, Sarah A. Stapley, Janine Dretzke, Danai Bem and Jowan G. Penn-Barwell

    Citation: Systematic Reviews 2015 4:161

    Content type: Protocol

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  9. Healthcare consumers, researchers, patients and policy makers increasingly use systematic reviews (SRs) to aid their decision-making process. However, the conduct of SRs can be a time-consuming and resource-in...

    Authors: Alexander Tsertsvadze, Yen-Fu Chen, David Moher, Paul Sutcliffe and Noel McCarthy

    Citation: Systematic Reviews 2015 4:160

    Content type: Commentary

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  10. Landmark studies in adult-onset type 1 diabetes (T1D) populations indicate that improved glycaemic control through use of intensive insulin therapy is strongly associated with reduced risk for the development ...

    Authors: Veena Mazarello Paes, Dimitrios Charalampopoulos, Amal R. Khanolkar, David Taylor-Robinson, Russell Viner, Julie Edge, Terence Stephenson and Rakesh Amin

    Citation: Systematic Reviews 2015 4:159

    Content type: Protocol

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  11. The matching of critical care service supply with demand is fundamental for the efficient delivery of advanced life support to patients in urgent need. Mismatch in this supply/demand relationship contributes t...

    Authors: S. Abolfazi Soltani, Armann Ingolfsson, David A. Zygun, Henry T. Stelfox, Lisa Hartling, Robin Featherstone, Dawn Opgenorth and Sean M. Bagshaw

    Citation: Systematic Reviews 2015 4:158

    Content type: Protocol

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  12. Smoking cessation before surgery reduces postoperative complications, and the benefit is positively associated with the duration of being abstinent before a surgical procedure. A key issue in providing preoper...

    Authors: Fujian Song, Tracey J. Brown, Annie Blyth, Vivienne Maskrey, Iain McNamara and Simon Donell

    Citation: Systematic Reviews 2015 4:157

    Content type: Research

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  13. The reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework was developed to determine potential public health impact of interventions (i.e., programs, policy, and practice). The pur...

    Authors: Samantha M. Harden, Bridget Gaglio, Jo Ann Shoup, Kimberlee A. Kinney, Sallie Beth Johnson, Fabiana Brito, Kacie C. A. Blackman, Jamie M. Zoellner, Jennie L. Hill, Fabio A. Almeida, Russell E. Glasgow and Paul A. Estabrooks

    Citation: Systematic Reviews 2015 4:155

    Content type: Research

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  14. Nebulised dornase alfa is used off-label in critically ill patients. We aimed to assess the benefits and harms of nebulised dornase alfa versus placebo, no prophylaxis, or hypertonic saline on patient-importan...

    Authors: Casper Claudius, Anders Perner and Morten Hylander Møller

    Citation: Systematic Reviews 2015 4:153

    Content type: Research

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  15. Current health and social care systems are providing suboptimal and fragmented care to the growing dementia population. Interventions aiming to coordinate care services for individuals with dementia and their ...

    Authors: Amy Backhouse, Chris Dickens, David Richards and Rose McCabe

    Citation: Systematic Reviews 2015 4:156

    Content type: Protocol

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  16. Though often used to control outbreaks, the efficacy of ward closure is unclear. This systematic review sought to identify studies defining and describing ward closure in outbreak control and to determine impa...

    Authors: Holly Wong, Katherine Eso, Ada Ip, Jessica Jones, Yoojin Kwon, Susan Powelson, Jill de Grood, Rose Geransar, Maria Santana, A. Mark Joffe, Geoffrey Taylor, Bayan Missaghi, Craig Pearce, William A. Ghali and John Conly

    Citation: Systematic Reviews 2015 4:152

    Content type: Research

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  17. Management and choice of sedation is important during critical illness in order to reduce patient suffering and to facilitate the delivery of care. Unfortunately, medications traditionally used for sedation in...

    Authors: Gennie Jing Wang, Emilie Belley-Coté, Lisa Burry, Mark Duffett, Timothy Karachi, Dan Perri, Waleed Alhazzani, Frederick D’Aragon, Hannah Wunsch and Bram Rochwerg

    Citation: Systematic Reviews 2015 4:154

    Content type: Protocol

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  18. Sepsis from burn injuries can result from colonisation of burn wounds, especially in large surface area burns. Reducing bacterial infection will reduce morbidity and mortality, and mortality for severe burns c...

    Authors: Johnny Kwei, Fenella D. Halstead, Janine Dretzke, Beryl A. Oppenheim and Naiem S. Moiemen

    Citation: Systematic Reviews 2015 4:150

    Content type: Protocol

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  19. Traumatic brain injury (TBI) is a leading cause of death and disability around the world. Management based on Brain Trauma Foundation (BTF) guidelines is widely accepted and thought to improve outcome. The obj...

    Authors: Yahya H Khormi, Ibrahim Gosadi, Sandra Campbell, Ambikaipakan Senthilselvan, Cian O’kelly and David Zygun

    Citation: Systematic Reviews 2015 4:149

    Content type: Protocol

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  20. Network meta-analysis is increasingly used to allow comparison of multiple treatment alternatives simultaneously, some of which may not have been compared directly in primary research studies. The majority of ...

    Authors: Chris Cameron, Bruce Fireman, Brian Hutton, Tammy Clifford, Doug Coyle, George Wells, Colin R. Dormuth, Robert Platt and Sengwee Toh

    Citation: Systematic Reviews 2015 4:147

    Content type: Commentary

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  21. Meeting the needs of the growing number of older people is a challenge for health and social care services. Home-based interventions aiming to modify health-related behaviours of frail older people have the po...

    Authors: Ana Jovicic, Benjamin Gardner, Celia Belk, Kalpa Kharicha, Steve Iliffe, Jill Manthorpe, Claire Goodman, Vari Drennan and Kate Walters

    Citation: Systematic Reviews 2015 4:151

    Content type: Protocol

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  22. Patient and public involvement in diabetes research is now actively encouraged in different countries because it is believed that involving people with experience of the condition will improve the quality and ...

    Authors: Janet Harris, Marit Graue, Trisha Dunning, Johannes Haltbakk, Gunhild Austrheim, Nina Skille, Berit Rokne and Marit Kirkevold

    Citation: Systematic Reviews 2015 4:146

    Content type: Protocol

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  23. A significant proportion of women exceeds or does not meet the Institute of Medicine’s gestational weight gain (GWG) guidelines. Inadequate, excessive GWG or weight loss during pregnancy is associated with an ...

    Authors: Taru Manyanga, Danilo F. da Silva, Zachary M. Ferraro, Alysha L. J. Harvey, Shanna Wilson, Holly N. Ockenden and Kristi B. Adamo

    Citation: Systematic Reviews 2015 4:145

    Content type: Protocol

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  24. Despite recent improvements, uptake and retention of mothers and infants in prevention of mother-to-child transmission (PMTCT) services remain well below target levels in many low- and middle-income countries ...

    Authors: Lisa M. Puchalski Ritchie, Monique van Lettow, Mina C. Hosseinipour, Nora E. Rosenberg, Sam Phiri, Megan Landes, Fabian Cataldo and Sharon E. Straus

    Citation: Systematic Reviews 2015 4:144

    Content type: Protocol

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  25. Total joint replacement (TJR) procedures have been one of the most rewarding interventions for treating patients suffering from joint disease. However, developing a periprosthetic joint infection (PJI) is a se...

    Authors: Paul E. Beaule, Beverley Shea, Hesham Abedlbary, Nadera Ahmadzai, Becky Skidmore, Ranjeeta Mallick, Brian Hutton, Alexandra C. Bunting, Julian Moran, Roxanne Ward and David Moher

    Citation: Systematic Reviews 2015 4:148

    Content type: Protocol

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    The Erratum to this article has been published in Systematic Reviews 2016 5:103

  26. Systematic reviews should provide trustworthy guidance to decision-makers, but their credibility is challenged by the selective reporting of trial results and outcomes. Some trials are not published, and even ...

    Authors: Evan Mayo-Wilson, Susan Hutfless, Tianjing Li, Gillian Gresham, Nicole Fusco, Jeffrey Ehmsen, James Heyward, Swaroop Vedula, Diana Lock, Jennifer Haythornthwaite, Jennifer L. Payne, Theresa Cowley, Elizabeth Tolbert, Lori Rosman, Claire Twose, Elizabeth A. Stuart…

    Citation: Systematic Reviews 2015 4:143

    Content type: Protocol

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    The Correction to this article has been published in Systematic Reviews 2018 7:48

  27. Several stigma reduction intervention strategies have been developed and tested for effectiveness in terms of increasing human immunodeficiency virus (HIV) test uptake. These strategies have been more effectiv...

    Authors: Subash Thapa, Karin Hannes, Margaret Cargo, Anne Buve and Catharina Mathei

    Citation: Systematic Reviews 2015 4:142

    Content type: Protocol

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  28. In public health, hard-to-reach populations are often recruited by non-probabilistic sampling methods that produce biased results. In order to overcome this, several sampling methods have been improved and dev...

    Authors: Ana B. Barros, Sonia F. Dias and Maria Rosario O. Martins

    Citation: Systematic Reviews 2015 4:141

    Content type: Research

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  29. In order to enable replication of effective complex interventions, systematic reviews need to provide evidence about their critical features and clear procedural details for their implementation. Currently, fe...

    Authors: Katy Sutcliffe, James Thomas, Gillian Stokes, Kate Hinds and Mukdarut Bangpan

    Citation: Systematic Reviews 2015 4:140

    Content type: Methodology

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  30. Acute kidney injury (AKI) is common and often leads to significant morbidity and/or death. The development of AKI, or complications associated with it, may be due to use of certain medications in at-risk patie...

    Authors: Andrew Morden, Jeremy Horwood, Penny Whiting, Jelena Savovic, Laurie Tomlinson, Thomas Blakeman, Charles Tomson, Alison Richards, Tracey Stone and Fergus Caskey

    Citation: Systematic Reviews 2015 4:139

    Content type: Protocol

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  31. Grey literature is an important source of information for large-scale review syntheses. However, there are many characteristics of grey literature that make it difficult to search systematically. Further, ther...

    Authors: Katelyn Godin, Jackie Stapleton, Sharon I. Kirkpatrick, Rhona M. Hanning and Scott T. Leatherdale

    Citation: Systematic Reviews 2015 4:138

    Content type: Methodology

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  33. Modern resuscitation strategies following haemorrhagic shock are influenced by global haemodynamic parameters such as blood pressure and cardiac output. Microcirculatory dysfunction in this context may persist...

    Authors: David N. Naumann, Janine Dretzke, Sam Hutchings and Mark J. Midwinter

    Citation: Systematic Reviews 2015 4:135

    Content type: Protocol

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  34. The use of information technology in healthcare is fast becoming an alternative and supporting method of providing many forms of services in a healthcare and health management setting. Telephone technology is ...

    Authors: Martin J. Downes, Merehau C. Mervin, Joshua M. Byrnes and Paul A. Scuffham

    Citation: Systematic Reviews 2015 4:134

    Content type: Protocol

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  35. Human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) is an aggressive form of breast cancer and is historically associated with poor outcomes compared with HER2-negative MBC....

    Authors: Eli J. Korner, Anne Morris, Isabel Elaine Allen, Sara Hurvitz, Mary S. Beattie and Bindu Kalesan

    Citation: Systematic Reviews 2015 4:133

    Content type: Protocol

    Published on:

  36. Chronic pain can contribute to disability, depression, anxiety, sleep disturbances, poor quality of life and increased health care costs, with close to 20 % of the adult population in Europe reporting chronic ...

    Authors: Louise J. Geneen, Denis J. Martin, Nicola Adams, Clare Clarke, Martin Dunbar, Derek Jones, Paul McNamee, Pat Schofield and Blair H. Smith

    Citation: Systematic Reviews 2015 4:132

    Content type: Research

    Published on:

  37. Problem alcohol drinking in homeless and vulnerably housed people can lead to malnutrition, which is associated with complications such as alcohol-related brain damage. Homeless alcohol drinkers are likely to ...

    Authors: Helen Thorley, Katie Porter, Clare Fleming, Tim Jones, Joanna Kesten, Elsa Marques, Alison Richards and Jelena Savović

    Citation: Systematic Reviews 2015 4:131

    Content type: Protocol

    Published on:

  38. Patients admitted to the intensive care unit with critical illness often experience significant physical impairments, which typically persist for many years following resolution of the original illness. Physic...

    Authors: Bronwen Connolly, Brenda O’Neill, Lisa Salisbury, Kathryn McDowell and Bronagh Blackwood

    Citation: Systematic Reviews 2015 4:130

    Content type: Protocol

    Published on:

  39. Despite a global increase in contraception use, its prevalence remains low in low- and middle-income countries. One strategy to improve uptake and use of contraception, as an essential complement to policies a...

    Authors: Loubna Belaid, Alexandre Dumont, Nils Chaillet, Vincent De Brouwere, Amel Zertal, Sennen Hounton and Valéry Ridde

    Citation: Systematic Reviews 2015 4:124

    Content type: Protocol

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  40. Systematic reviews are important for decision-makers. They offer many potential benefits but are often written in technical language, are too long, and do not contain contextual details which makes them hard t...

    Authors: Jennifer Petkovic, Vivian Welch and Peter Tugwell

    Citation: Systematic Reviews 2015 4:122

    Content type: Protocol

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  41. Of the more than 104,000 Canadians who underwent elective total joint arthroplasty (TJA) surgery in 2012–2013 for hip and knee osteoarthritis (OA), 40 and 60 %, respectively, were obese. Obesity is associated ...

    Authors: Michelle Lui, C. Allyson Jones and Marie D. Westby

    Citation: Systematic Reviews 2015 4:121

    Content type: Research

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  42. The demand for accelerated forms of evidence synthesis is on the rise, largely in response to requests by health care decision makers for expeditious assessment and up-to-date information about health care tec...

    Authors: Julie Polisena, Chantelle Garritty, Craig A. Umscheid, Chris Kamel, Kevin Samra, Jeannette Smith and Ann Vosilla

    Citation: Systematic Reviews 2015 4:137

    Content type: Commentary

    Published on:

  43. Africa is considered an area of high endemicity for hepatitis A virus infection. However, in the past two decades, tremendous progress has been made in improving water sources and sanitation which are risk fac...

    Authors: Tiwonge J. Kanyenda, Leila H. Abdullahi, Gregory D. Hussey and Benjamin M. Kagina

    Citation: Systematic Reviews 2015 4:129

    Content type: Protocol

    Published on:

  44. Many systematic reviews have evaluated the effectiveness of interventions to prevent, delay, or decrease frailty symptoms, but no effort has been made to identify, map, and synthesize the findings from reviews...

    Authors: Michael G. Wilson, François Béland, Dominic Julien, Lise Gauvin, G. Emmanuel Guindon, Denis Roy, Kaitryn Campbell, Donna G. Comeau, Heather Davidson, Parminder Raina, Deborah Sattler and Brenda Vrkljan

    Citation: Systematic Reviews 2015 4:128

    Content type: Protocol

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  45. Inhaled steroids have been studied for both prevention and treatment of bronchopulmonary dysplasia (BPD). Results have been inconsistent. Recently, a large randomized controlled trial (RCT) has been reported.

    Authors: Eric S. Shinwell, Igor Portnov, Joerg Meerpohl, Tanja Karen and Dirk Bassler

    Citation: Systematic Reviews 2015 4:127

    Content type: Protocol

    Published on:

  46. Specialist palliative care (SPC) interventions aim to relieve and prevent suffering in the physical, psychological, social, and spiritual domain. Therefore, SPC is carried out by a multi-professional team with...

    Authors: Jan Gaertner, Waldemar Siemens, Gerd Antes, Joerg J Meerpohl, Carola Xander, Guido Schwarzer, Stephanie Stock and Gerhild Becker

    Citation: Systematic Reviews 2015 4:123

    Content type: Protocol

    Published on:

  47. One of the most efficient radiation protection methods to reduce the risk of adverse health outcomes in case of accidental radioactive iodine release is the administration of potassium iodine (KI). Although KI...

    Authors: Steffen Dreger, Manuela Pfinder, Lara Christianson, Stefan K Lhachimi and Hajo Zeeb

    Citation: Systematic Reviews 2015 4:126

    Content type: Protocol

    Published on:

  48. Fine needle aspiration biopsy (FNAB) is an accurate test commonly used to determine whether thyroid nodules are malignant in adults. However, less is known about its diagnostic accuracy for this purpose in chi...

    Authors: Sarah W. Lai, Derek J. Roberts, Doreen M. Rabi and Karin Y. Winston

    Citation: Systematic Reviews 2015 4:120

    Content type: Protocol

    Published on:

  49. Polycystic ovarian syndrome (PCOS) is a common reproductive endocrine disease that is seen among adolescent women. Currently, there is limited evidence to support treatment options leading to considerable vari...

    Authors: Reem A. Al Khalifah, Iván D. Flórez, Brittany Dennis, Binod Neupane, Lehana Thabane and Ereny Bassilious

    Citation: Systematic Reviews 2015 4:125

    Content type: Protocol

    Published on:

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