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  1. Trial registries were established to combat publication bias by creating a comprehensive and unambiguous record of initiated clinical trials. However, the proliferation of registries and registration policies ...

    Authors: Gert van Valkenhoef, Russell F. Loane and Deborah A. Zarin

    Citation: Systematic Reviews 2016 5:116

    Content type: Research

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  2. The NHS needs valid information on the safety and effectiveness of healthcare interventions. Cochrane systematic reviews are an important source of this information. Traditionally, Cochrane has attempted to id...

    Authors: Ian Roberts and Katharine Ker

    Citation: Systematic Reviews 2016 5:115

    Content type: Commentary

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  3. There is increasing pressure to address the social determinants of health (SDoH) and health inequities through the implementation of culturally acceptable interventions particularly in Sub-Saharan Africa (SSA)...

    Authors: Ebenezer Owusu-Addo, Andre M.N. Renzaho, Ajay S. Mahal and Ben J. Smith

    Citation: Systematic Reviews 2016 5:114

    Content type: Protocol

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  4. Studies show that people with dementia do not receive the same amount of analgesia after a hip or pelvic fracture compared to those without cognitive impairment. However, there is no systematic review that sho...

    Authors: S. Kuske, K. Moschinski, S. Andrich, A. Stephan, I. Gnass, E. Sirsch and A. Icks

    Citation: Systematic Reviews 2016 5:113

    Content type: Protocol

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  5. Over the years, family-centered care has evolved as the “gold standard” model for the provision of healthcare services. With the advent of family-centered approach to care comes the inherent need to provide su...

    Authors: Jermaine M. Dambi, Jennifer Jelsma, Tecla Mlambo, Matthew Chiwaridzo, Cathrine Tadyanemhandu, Mildred T. Chikwanha and Lieselotte Corten

    Citation: Systematic Reviews 2016 5:112

    Content type: Protocol

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  6. The prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is increasing. This has spurred the development and publication of clinical practice guidelines (CPGs) for the management of paedia...

    Authors: Dena Zeraatkar, Ahmed Nahari, Pei-Wen Wang, Emily Kearsley, Nicole Falzone, Michael Xu, Laura Banfield, Lehana Thabane and M. Constantine Samaan

    Citation: Systematic Reviews 2016 5:111

    Content type: Protocol

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  7. The diagnosis, management, and treatment for hepatitis C virus (HCV) infection (the “HCV care continuum”) have improved in recent years. People who use drugs (PWUD) have a prevalence of HCV infection from 30 t...

    Authors: Jennifer R. Reed, Ashly E. Jordan, David C. Perlman, Daniel J. Smith and Holly Hagan

    Citation: Systematic Reviews 2016 5:110

    Content type: Protocol

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  8. Infant and young child feeding practices, including breastfeeding and complementary feeding of children under 2 years old, are crucially influenced by parent and family perceptions and experiences. Given the u...

    Authors: Alessandra N. Bazzano, Aiko Kaji, Erica Felker-Kantor, Lisa Saldanha and John Mason

    Citation: Systematic Reviews 2016 5:109

    Content type: Protocol

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  9. Proliferative vitreoretinopathy (PVR) is a known complication of retinal detachment surgery. It has been postulated that the establishment of PVR involves inflammatory and ischaemic processes. Surgical and cli...

    Authors: Rishika Chaudhary, Janine Dretzke, Robert Scott, Ann Logan and Richard Blanch

    Citation: Systematic Reviews 2016 5:107

    Content type: Protocol

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  10. People with bipolar disorder (BD) have a mortality gap of up to 20 years compared to the general population. Physical conditions, such as cardiovascular disease (CVD) and cancer, cause the majority of excess d...

    Authors: Frances J. Kay-Lambkin, Louise Thornton, Julia M. Lappin, Tanya Hanstock, Louisa Sylvia, Felice Jacka, Amanda L. Baker, Michal Berk, Phillip B. Mitchell, Robin Callister, Naomi Rogers, Stephanie Webster, Simon Dennis, Christopher Oldmeadow, Andrew MacKinnon, Christopher Doran…

    Citation: Systematic Reviews 2016 5:106

    Content type: Protocol

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  11. Despite its shortcomings, warfarin is still the most commonly prescribed anticoagulant to prevent thromboembolism in children. In adults, numerous studies confirmed the robust relationship between warfarin mai...

    Authors: Masanobu Takeuchi, Tohru Kobayashi, Leonardo R. Brandão and Shinya Ito

    Citation: Systematic Reviews 2016 5:105

    Content type: Protocol

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  12. Cochrane Child Health maintains a register of child-relevant Cochrane systematic reviews (SRs) to provide a comprehensive source of high-quality evidence. However, a large number of SRs are published outside o...

    Authors: Lisa Hartling, Kassi Shave, Denise Thomson, Ricardo M. Fernandes, Aireen Wingert and Katrina Williams

    Citation: Systematic Reviews 2016 5:104

    Content type: Research

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  13. Authors: Paul E. Beaule, Beverley Shea, Hesham Abdelbary, Nadera Ahmadzai, Becky Skidmore, Ranjeeta Mallick, Brian Hutton, Alexandra C. Bunting, Julian Moran, Roxanne Ward and David Moher

    Citation: Systematic Reviews 2016 5:103

    Content type: Erratum

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    The original article was published in Systematic Reviews 2015 4:148

  14. Lay health workers (LHWs) are utilised as a channel of delivery in many health interventions. While they have no formal professional training related to their role, they utilise their connections with the targ...

    Authors: Faith Hodgins, Wendy Gnich, Alastair J. Ross, Andrea Sherriff and Heather Worlledge-Andrew

    Citation: Systematic Reviews 2016 5:102

    Content type: Protocol

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  15. Pediatric brain tumors are the most common solid tumors in children. Advances in understanding the hallmarks of cancer biology and novel therapies have led to an increasing number of survivors of childhood bra...

    Authors: Kuan-Wen Wang, Marlie Valencia, Laura Banfield, Ruth Chau, Adam Fleming, Sheila K. Singh, Sarah Burrow, Russell J. de Souza, Lehana Thabane and M. Constantine Samaan

    Citation: Systematic Reviews 2016 5:101

    Content type: Protocol

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  16. Chronic liver disease (CLD) is a major health burden worldwide. Liver cirrhosis, a form of CLD is the fifth most common cause of death in the UK. Acute-on-chronic liver failure (ACLF) is the result of an acute...

    Authors: Nwe Ni Than, Claire L. Tomlinson, Debashis Haldar, Andrew L. King, David Moore and Philip N. Newsome

    Citation: Systematic Reviews 2016 5:100

    Content type: Protocol

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  17. The extracorporeal membrane carbon dioxide removal (ECCO2R) system is primarily designed for the purpose of removing CO2 from the body for patients with potentially reversible severe acute hypercapnic respiratory...

    Authors: Zulian Liu, Rui V. Duarte, Sue Bayliss, George Bramley and Carole Cummins

    Citation: Systematic Reviews 2016 5:98

    Content type: Protocol

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  18. The term “health literacy” (HL) was first coined in 1974, and its most common definition is currently defined as a person’s ability to access, understand, evaluate, communicate, and use health information to m...

    Authors: Jessica Shum, Iraj Poureslami, Mary M. Doyle-Waters and J. Mark FitzGerald

    Citation: Systematic Reviews 2016 5:97

    Content type: Protocol

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  19. Hypertension control through pharmacological treatment has led to substantial benefits in the prevention of morbidity and mortality from cardiovascular diseases. However, evidence from a number of studies sugg...

    Authors: Eimear C. Morrissey, Hannah Durand, Robby Nieuwlaat, Tamara Navarro, R. Brian Haynes, Jane C. Walsh and Gerard J. Molloy

    Citation: Systematic Reviews 2016 5:96

    Content type: Protocol

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  20. “Clinical ethics consultation” (CEC) is the provision of consultative services by an individual or team with the aim of helping health professionals, patients, and their families grapple with difficult ethical...

    Authors: Louis Leslie, Rebecca Frances Cherry, Abbas Mulla, Jean Abbott, Kristin Furfari, Jacqueline J. Glover, Benjamin Harnke and Matthew K. Wynia

    Citation: Systematic Reviews 2016 5:95

    Content type: Protocol

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  21. Ankle sprains are a significant clinical problem. Researchers have identified a multitude of factors contributing to the presence of recurrent ankle sprains including deficits in balance, postural control, kin...

    Authors: Cassandra Thompson, Siobhan Schabrun, Rick Romero, Andrea Bialocerkowski and Paul Marshall

    Citation: Systematic Reviews 2016 5:94

    Content type: Protocol

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  22. The use of non-drug, non-health-service interventions has been proposed as a cost-effective alternative to help those with long-term conditions manage their illness and improve their health and well-being. Int...

    Authors: Kerryn Husk, Kelly Blockley, Rebecca Lovell, Alison Bethel, Dan Bloomfield, Sara Warber, Mark Pearson, Iain Lang, Richard Byng and Ruth Garside

    Citation: Systematic Reviews 2016 5:93

    Content type: Protocol

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  23. Autologous skin grafting is an important modality for wound coverage; however, it can result in donor site morbidity. Epidermal grafting is an emerging option to overcome this challenge. Furthermore, it can be...

    Authors: Muholan Kanapathy, Oliver J Smith, Nadine Hachach-Haram, Nicola Bystrzonowski, Afshin Mosahebi and Toby Richards

    Citation: Systematic Reviews 2016 5:92

    Content type: Protocol

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  24. Eczema, synonymous with atopic eczema or atopic dermatitis, is a chronic skin disease that has a similar impact on health-related quality of life as other chronic diseases. The proposed research aims to provid...

    Authors: Tracey Helen Sach, Emma McManus, Christopher Mcmonagle and Nick Levell

    Citation: Systematic Reviews 2016 5:90

    Content type: Protocol

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  25. Pulmonary arterial hypertension (PAH) is a rare disease (15 cases per million) that is characterized by widespread loss of the pulmonary microcirculation and elevated pulmonary vascular resistance leading to p...

    Authors: Colin M. Suen, Alex Zhai, Manoj M. Lalu, Christopher Welsh, Brendan M. Levac, Dean Fergusson, Lauralyn McIntyre and Duncan J. Stewart

    Citation: Systematic Reviews 2016 5:89

    Content type: Protocol

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  26. Poor physical health and fitness increases the risk of death and complications after major elective surgery. Pre-admission interventions to improve patients’ health and fitness (referred to as prehabilitation)...

    Authors: Rachel Perry, Lauren J. Scott, Alison Richards, Anne M. Haase, Jelena Savović, Andrew R. Ness, Charlotte Atkinson, Jessica Harris, Lucy Culliford, Sanjoy Shah and Maria Pufulete

    Citation: Systematic Reviews 2016 5:88

    Content type: Protocol

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  27. There is growing interest in using machine learning approaches to priority rank studies and reduce human burden in screening literature when conducting systematic reviews. In addition, identifying addressable ...

    Authors: Brian E. Howard, Jason Phillips, Kyle Miller, Arpit Tandon, Deepak Mav, Mihir R. Shah, Stephanie Holmgren, Katherine E. Pelch, Vickie Walker, Andrew A. Rooney, Malcolm Macleod, Ruchir R. Shah and Kristina Thayer

    Citation: Systematic Reviews 2016 5:87

    Content type: Methodology

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  28. Osteoarthritis affects 1 % of the world’s population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are commonly used in Brazil to manage symptoms associated with...

    Authors: Mariana Del Grossi Moura, Luciane Cruz Lopes, Maique Weber Biavatti, Jason W. Busse, Li Wang, Sean Alexander Kennedy, Neera Bhatnaga and Cristiane de Cássia Bergamaschi

    Citation: Systematic Reviews 2016 5:86

    Content type: Protocol

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  29. Under the shadow of the tobacco epidemic, the sale and use of e-cigarettes and other vapour devices is increasing dramatically. A contentious debate has risen within public health over the harms and benefits o...

    Authors: Marjorie MacDonald, Renee O’Leary, Tim Stockwell and Dan Reist

    Citation: Systematic Reviews 2016 5:85

    Content type: Protocol

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  30. Growing literature has demonstrated that patients admitted to hospital during weekends tend to have less favourable outcomes, including increased mortality, compared with similar patients admitted during weekd...

    Authors: Yen-Fu Chen, Amunpreet Boyal, Elizabeth Sutton, Xavier Armoiry, Samuel Watson, Julian Bion and Carolyn Tarrant

    Citation: Systematic Reviews 2016 5:84

    Content type: Protocol

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  31. Sepsis is a life-threatening condition and major contributor to public health and economic burden in the industrialised world. The difficulties in accurate diagnosis lead to great variability in estimates of s...

    Authors: Alexander Tsertsvadze, Pam Royle, Farah Seedat, Jennifer Cooper, Rebecca Crosby and Noel McCarthy

    Citation: Systematic Reviews 2016 5:81

    Content type: Research

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  32. The Cochrane risk of bias tool for randomized clinical trials was introduced in 2008 and has frequently been commented on and used in systematic reviews. We wanted to evaluate the tool by reviewing published c...

    Authors: Lars Jørgensen, Asger S. Paludan-Müller, David R. T. Laursen, Jelena Savović, Isabelle Boutron, Jonathan A. C. Sterne, Julian P. T. Higgins and Asbjørn Hróbjartsson

    Citation: Systematic Reviews 2016 5:80

    Content type: Research

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  33. Interventions to improve medication adherence are diverse and complex. Consequently, synthesizing this evidence is challenging. We aimed to extend the results from an existing systematic review of intervention...

    Authors: Leila Kahwati, Meera Viswanathan, Carol E. Golin, Heather Kane, Megan Lewis and Sara Jacobs

    Citation: Systematic Reviews 2016 5:83

    Content type: Research

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  34. Systematic reviews evaluating complex interventions often encounter substantial clinical heterogeneity in intervention components and implementation features making synthesis challenging. Qualitative comparati...

    Authors: Leila Kahwati, Sara Jacobs, Heather Kane, Megan Lewis, Meera Viswanathan and Carol E. Golin

    Citation: Systematic Reviews 2016 5:82

    Content type: Methodology

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  35. Systematic reviews of behaviour change interventions for smoking cessation vary in scope, quality, and applicability. The current review aims to generate more accurate and useful findings by (1) a detailed ana...

    Authors: Marijn de Bruin, Wolfgang Viechtbauer, Maarten C. Eisma, Jamie Hartmann-Boyce, Robert West, Eleanor Bull, Susan Michie and Marie Johnston

    Citation: Systematic Reviews 2016 5:77

    Content type: Protocol

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  36. Critically ill patients have an increased risk of developing delirium during their intensive care stay. To date, pharmacological interventions have not been shown to be effective for delirium management but no...

    Authors: Leona Bannon, Jennifer McGaughey, Mike Clarke, Daniel Francis McAuley and Bronagh Blackwood

    Citation: Systematic Reviews 2016 5:75

    Content type: Protocol

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  37. Erythema migrans represents an early cutaneous and most common manifestation of Lyme borreliosis. Recommendations regarding pharmacological agents, dose and duration of treatment are subject of intense debate....

    Authors: Gabriel Torbahn, Heidelore Hofmann, Roman Allert, Michael H. Freitag, Rick Dersch, Volker Fingerle, Harriet Sommer, Edith Motschall, Jörg J. Meerpohl and Christine Schmucker

    Citation: Systematic Reviews 2016 5:73

    Content type: Protocol

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  38. Lumbar spinal fusion for degenerative disorders of the lumbar spine is frequently used, despite current research presenting inconclusive evidence. This study aims to systematically review and meta-analyse the ...

    Authors: Niek Koenders, Alison Rushton, Nicola Heneghan, Martin L. Verra, Paul Willems, Thomas Hoogeboom and J Bart Staal

    Citation: Systematic Reviews 2016 5:72

    Content type: Protocol

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  39. The parameters of the optic disc and peripapillary retinal nerve fibre layer (pRNFL) in children may vary with disease processes that contribute to visual impairment and blindness and so could be useful as an ...

    Authors: Alexandra L. Creavin, Cathy Williams, Kate Tilling, Nicholas Timpson and Julian P. T. Higgins

    Citation: Systematic Reviews 2016 5:71

    Content type: Protocol

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  40. District health managers play a key role in the effectiveness of decentralized health systems in low- and middle-income countries. Inadequate management and leadership skills often hamper their ability to impr...

    Authors: Zakaria Belrhiti, Andrew Booth, Bruno Marchal and Roosmarijn Verstraeten

    Citation: Systematic Reviews 2016 5:70

    Content type: Protocol

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  41. Authors: Karen M. Goldstein, Jennifer R. McDuffie, Megan Shepherd-Banigan, Deanna Befus, Remy R. Coeytaux, Megan G. Van Noord, Adam P. Goode, Varsha Masilamani, Soheir Adam, Avishek Nagi and John W. Williams Jr

    Citation: Systematic Reviews 2016 5:69

    Content type: Erratum

    Published on:

    The original article was published in Systematic Reviews 2016 5:56

  42. The global transfer of nursing and midwifery education to higher education institutes has led to student nurses and midwives experiencing challenges previously faced by traditional third-level students, includ...

    Authors: Jean Carragher and Jennifer McGaughey

    Citation: Systematic Reviews 2016 5:68

    Content type: Protocol

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  43. For people with end-stage kidney disease on hemodialysis, exercise during the dialysis treatment (intradialytic exercise) may promote exercise adherence and enhance aspects of the dialysis treatment. However, ...

    Authors: Stephanie Thompson, Alex Clark, Anita Molzahn, Scott Klarenbach and Marcello Tonelli

    Citation: Systematic Reviews 2016 5:67

    Content type: Protocol

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