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  1. High-intensity interval training (HIIT) has shown to confer cognitive benefits in healthy adults, via a mechanism purportedly driven by the exercise metabolite lactate. However, our understanding of the exerci...

    Authors: Nithin Jacob, Isis So, Bhanu Sharma, Susan Marzolini, Maria Carmela Tartaglia and Robin Green
    Citation: Systematic Reviews 2022 11:31
    Content type: Protocol Published on:

  2. An Italian project aims to review the scientific literature on the possible carcinogenicity of radiofrequency (100 kHz–300 GHz) electromagnetic field (RF-EMF) exposure. The ENEA team has to carry out a systema...

    Authors: Rosanna Pinto, Lucia Ardoino, Paola Giardullo, Paola Villani and Carmela Marino
    Citation: Systematic Reviews 2022 11:29
    Content type: Protocol Published on:

  3. Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) have impairing levels of difficulty paying attention, impulsive behaviour and/or hyperactivity. ADHD causes extensive difficulties ...

    Authors: Abigail E. Russell, Darren Moore, Amy Sanders, Barnaby Dunn, Rachel Hayes, Judi Kidger, Edmund Sonuga-Barke, Linda Pfiffner and Tamsin Ford
    Citation: Systematic Reviews 2022 11:28
    Content type: Protocol Published on:

  4. Dysphagia (swallowing difficulty) is one of the most common and debilitating sequelae of head and neck cancer (HNC). Patient-reported outcome measures (PROMs) are a fundamental component of dysphagia outcomes ...

    Authors: Beatrice Manduchi, Zhiyao Che, Margaret I. Fitch, Jolie Ringash, Doris Howell and Rosemary Martino
    Citation: Systematic Reviews 2022 11:27
    Content type: Protocol Published on:

  6. Microphthalmos and nanophthalmos are uncommon ocular conditions, whereby affected eyes have smaller dimensions compared to the normal population. Microphthalmos and nanophthalmos present several challenges to ...

    Authors: Naseer Ally, Sarah Ismail and Hassan Dawood Alli
    Citation: Systematic Reviews 2022 11:25
    Content type: Protocol Published on:

  7. Authors: Sylvain Boet, Joseph K. Burns, Olivia Cheng-Boivin, Hira Khan, Kendra Derry, Deric Diep, Abdul Hadi Djokhdem, Sung Wook Um, Johnny W. Huang, Danica Paré, Mimi Deng, Liza Begunova, Linda Yi Ning Fei, Maryam Bezzahou, Pium Sonali Andrahennadi, Elysia Grose…
    Citation: Systematic Reviews 2022 11:24
    Content type: Correction Published on:

    The original article was published in Systematic Reviews 2021 10:276

  8. The use of thiazide (T) diuretics for the treatment of hypertension may be associated with adverse metabolic effects, which can be minimized by combining thiazides with potassium-sparing (PS) diuretics. The ad...

    Authors: Vítor M. Martins, Patrícia K. Ziegelmann, Lucas Helal, Filipe Ferrari, Marcelo B. Lucca, Sandra C. Fuchs and Flávio D. Fuchs
    Citation: Systematic Reviews 2022 11:23
    Content type: Protocol Published on:

  9. While the mental health of immigrants is a growing issue that is attracting increasing interest from researchers, the same cannot be said for the mental health of immigrant students especially for internationa...

    Authors: Christelle Dombou, Olumuyiwa Omonaiye, Sarah Fraser, Jude Mary Cénat and Sanni Yaya
    Citation: Systematic Reviews 2022 11:22
    Content type: Protocol Published on:

  10. Depression is one of the commonest mental disorders in primary care but is poorly identified. The objective of this review was to determine the level of detection of depression by primary care clinicians and i...

    Authors: Abebaw Fekadu, Mekdes Demissie, Rahel Birhane, Girmay Medhin, Tesera Bitew, Maji Hailemariam, Abebaw Minaye, Kassahun Habtamu, Barkot Milkias, Inge Petersen, Vikram Patel, Anthony J. Cleare, Rosie Mayston, Graham Thornicroft, Atalay Alem, Charlotte Hanlon…
    Citation: Systematic Reviews 2022 11:21
    Content type: Systematic review update Published on:

  11. Income inequality has been linked to health and mortality. While there has been extensive research exploring the relationship, the evidence for whether the relationship is causal remains disputed. We describe ...

    Authors: Michal Shimonovich, Anna Pearce, Hilary Thomson, Gerry McCartney and Srinivasa Vittal Katikireddi
    Citation: Systematic Reviews 2022 11:20
    Content type: Protocol Published on:

  12. The need to include males who require joint spousal decisions is critical in achieving key reproductive health indicators. Low involvement of males in family planning use is one of the contributing factors for...

    Authors: Etsay Woldu Anbesu, Setognal Birara Aychiluhm and Zinabu Hadush Kahsay
    Citation: Systematic Reviews 2022 11:19
    Content type: Protocol Published on:

  13. Lymphedema is a condition that affects up to 130 million subjects worldwide. Since it is related to several complications and a significant reduction in terms of quality of life, it is a heavy burden not only ...

    Authors: Patrick A. Will, Zhenzhen Wan, Svenja E. Seide, Juan Enrique Berner, Ulrich Kneser, Emre Gazyakan and Christoph Hirche
    Citation: Systematic Reviews 2022 11:18
    Content type: Protocol Published on:

  14. Patient safety is a fundamental principle of health care but is one of the biggest challenges currently faced and a serious public health problem, since the occurrence of adverse events is probably one of the ...

    Authors: Helga Catarina Santos Alves de Oliveira, Ricardo Rafael Marques, Maria Alice dos Santos Curado, Maria Filomena Mendes Gaspar and Paulo Jorge dos Santos Sousa
    Citation: Systematic Reviews 2022 11:17
    Content type: Protocol Published on:

  16. This study developed, calibrated and evaluated a machine learning (ML) classifier designed to reduce study identification workload in maintaining the Cochrane COVID-19 Study Register (CCSR), a continuously upd...

    Authors: Ian Shemilt, Anna Noel-Storr, James Thomas, Robin Featherstone and Chris Mavergames
    Citation: Systematic Reviews 2022 11:15
    Content type: Methodology Published on:

  17. There are over 1 million adults with a learning disability in the UK, of whom approximately 20% displaying behaviours that challenge others. Two thirds of people with learning disabilities live in the family h...

    Authors: J. Vseteckova, J. Jordan, E. Tilley, M. Larkin, S. Ryan and L. M. Wallace
    Citation: Systematic Reviews 2022 11:14
    Content type: Protocol Published on:

  18. Identifying cancer-specific physical activity programs and post-secondary courses targeting students in academic settings (i.e., “real world” opportunities) may promote physical activity behaviors among cancer...

    Authors: Angela J. Fong, Catherine M. Sabiston, Kaitlyn D. Kauffeldt and Jennifer R. Tomasone
    Citation: Systematic Reviews 2022 11:13
    Content type: Methodology Published on:

  19. Stigma is a social process that impedes access to support for mental health conditions and alcohol and other drug (AOD) use, particularly for people from migrant and ethnic minority backgrounds. There is limit...

    Authors: Caitlin H. Douglass, Megan S. C. Lim, Karen Block, Gerald Onsando, Margaret Hellard, Peter Higgs, Charles Livingstone and Danielle Horyniak
    Citation: Systematic Reviews 2022 11:12
    Content type: Protocol Published on:

  20. Systematic review is an indispensable tool for optimal evidence collection and evaluation in evidence-based medicine. However, the explosive increase of the original literatures makes it difficult to accomplis...

    Authors: Yuelun Zhang, Siyu Liang, Yunying Feng, Qing Wang, Feng Sun, Shi Chen, Yiying Yang, Xin He, Huijuan Zhu and Hui Pan
    Citation: Systematic Reviews 2022 11:11
    Content type: Protocol Published on:

  21. Complementary and Alternative Medicine (CAM) has gained popularity among the general population, but its acceptance and use among medical specialists have been inconclusive. This systematic review aimed to ide...

    Authors: Phanupong Phutrakool and Krit Pongpirul
    Citation: Systematic Reviews 2022 11:10
    Content type: Research Published on:

  22. In recent decades, the literature on Social Network Analysis and health has experienced a significant increase. Disease transmission, health behavior, organizational networks, social capital, and social suppor...

    Authors: Rosario Fernández-Peña, María-Antonia Ovalle-Perandones, Pilar Marqués-Sánchez, Carmen Ortego-Maté and Nestor Serrano-Fuentes
    Citation: Systematic Reviews 2022 11:9
    Content type: Protocol Published on:

  23. Prospective registration aims to reduce bias in the conduct and reporting of research and to increase transparency. In addition, prospective registration of systematic reviews is argued to help preventing unin...

    Authors: Dawid Pieper and Tanja Rombey
    Citation: Systematic Reviews 2022 11:8
    Content type: Commentary Published on:

  25. People with depression often present with concurrent cognitive impairment. Computerized cognitive training (CCT) is a safe and efficacious strategy to maintain or enhance cognitive performance in a range of cl...

    Authors: Amit Lampit, Nathalie H. Launder, Ruth Minkov, Alice Rollini, Christopher G. Davey, Carsten Finke, Nicola T. Lautenschlager and Hanna Malmberg Gavelin
    Citation: Systematic Reviews 2022 11:6
    Content type: Protocol Published on:

  26. Infection is a common problem and a major cause of morbidity and mortality for patients in intensive care units (ICUs). According to published meta-analyses, oral care has been found to reduce the risk of noso...

    Authors: Xiaoxia Tang, Yunxia Shen, Xuejiao Pan, Jianglong Liao, Yanfei Xu, Wen Luo, Xiaolin Zhang, Chun’e Li, Qing Wan, Xin Cai, Xiaomei Zhang, Tao Wang and Guilan Zhang
    Citation: Systematic Reviews 2022 11:5
    Content type: Protocol Published on:

  27. Despite the fact that nephron-sparing treatment is considered preferable from a surgical perspective patients’ quality of life (QoL) following different types of nephron-sparing treatments remains unclear.

    Authors: Theresa Junker, Louise Duus, Benjamin S. B. Rasmussen, Nessn Azawi, Lars Lund, Ole Graumann and Birgitte Nørgaard
    Citation: Systematic Reviews 2022 11:4
    Content type: Research Published on:

  28. The aim of the present study was to provide an overview of gingival crevicular fluid (GCF) bone turnover markers (BTMs) concerning the physiology of orthodontic tooth movement (OTM) and assess their potential ...

    Authors: L. Kakali, I. Giantikidis, I. Sifakakis, E. Kalimeri, I. Karamani, E. Mavrogonatou and D. Kloukos
    Citation: Systematic Reviews 2022 11:3
    Content type: Systematic review update Published on:

  29. Early prostate cancer (PCa) treatment interventions may leave men with debilitating sexual side effects, especially when not diagnosed or present at initial follow-up treatment. Men are often embarrassed to di...

    Authors: Pierre Röscher, Ronisha Sathiram, Joanne E. Milios and Jacqueline M. van Wyk
    Citation: Systematic Reviews 2022 11:2
    Content type: Research Published on:

  30. Individuals with obesity are at higher risk of experiencing complications during their pregnancy and may also experience infertility, requiring assisted reproductive technologies (ART) to conceive. The current...

    Authors: Kameela Alibhai, Isabella Churchill, Tannys Vause and Heather Anne Lochnan
    Citation: Systematic Reviews 2022 11:1
    Content type: Protocol Published on:

  31. In December 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 was identified as the cause of an acute respiratory disease, coronavirus disease 2019 (COVID-19). Given the lack of valida...

    Authors: Thanansayan Dhivagaran, Umaima Abbas, Fahad Butt, Luckshann Arunasalam and Oswin Chang
    Citation: Systematic Reviews 2021 10:317
    Content type: Protocol Published on:

  32. Whether due to aging, disability, injury, or other circumstances, an increasing number of Canadians experience functional limitations that reduce their ability to participate in activities of daily life. While...

    Authors: Brad W. R. Roberts, Abdulrahman Al Bochi, Mark Weiler, Yashoda Sharma, Cesar Marquez-Chin, Steven Pong, Jessica Babineau, Waqas Sajid, Tilak Dutta and Albert H. Vette
    Citation: Systematic Reviews 2021 10:316
    Content type: Protocol Published on:

  33. The comparative safety and efficacy between anti-vascular endothelial growth factor agents (anti-VEGFs) and between combined therapies for patients with neovascular age-related macular degeneration (nAMD) is u...

    Authors: Andrea C. Tricco, Sonia M. Thomas, Erin Lillie, Areti Angeliki Veroniki, Jemila S. Hamid, Ba’ Pham, Taehoon Lee, Arnav Agarwal, Jane P. Sharpe, Alistair Scott, Rachel Warren, Ronak Brahmbhatt, Erin Macdonald, Ghayath Janoudi, Rajeev H. Muni, Carolina L. M. Francisconi…
    Citation: Systematic Reviews 2021 10:315
    Content type: Research Published on:

  34. Dyspnea with bilateral pulmonary edema is common among patients in emergency departments (EDs) or intensive care units (ICUs). For the initial management of patients with this condition, cardiopulmonary edema ...

    Authors: Takero Terayama, Takuya Taniguchi, Ryosuke Imai, Keisuke Anan, Takuo Yoshida, Koichi Ando, Satoshi Okamori and Yohei Okada
    Citation: Systematic Reviews 2021 10:314
    Content type: Protocol Published on:

  35. The Extension for Community Healthcare Outcomes (ECHO) Model of continuing tele-education is an innovative guided-practice model aiming at amplifying healthcare professionals’ competencies in the management of...

    Authors: Gabrielle Chicoine, José Côté, Jacinthe Pepin, Guillaume Fontaine, Marc-André Maheu-Cadotte, Quan Nha Hong, Geneviève Rouleau, Daniela Ziegler and Didier Jutras-Aswad
    Citation: Systematic Reviews 2021 10:313
    Content type: Protocol Published on:

  36. Swallowing impairment (dysphagia) following brain injury can lead to life-threatening complications such as dehydration, aspiration pneumonia and acute choking episodes. In adult therapeutic practice, there is...

    Authors: Rhiannon Halfpenny, Alexandra Stewart, Paula Kelly, Eleanor Conway and Christina Smith
    Citation: Systematic Reviews 2021 10:312
    Content type: Protocol Published on:

  37. Urban health is a field of research and practice that has attracted the interest of various disciplines. While it is encouraged for diverse disciplines to contribute to a multidisciplinary field of study such ...

    Authors: Jinhee Kim, Ben Harris-Roxas, Evelyne de Leeuw, David Lilley, Alana Crimeen and Peter Sainsbury
    Citation: Systematic Reviews 2021 10:311
    Content type: Protocol Published on:

  39. Although systematic reviews are considered as central components in evidence-based practice, they currently face an important challenge to keep up with the exponential publication rate of clinical trials. Afte...

    Authors: S. Elbers, H. Wittink, U. Kaiser, J. Kleijnen, J. Pool, A. Köke and R. Smeets
    Citation: Systematic Reviews 2021 10:309
    Content type: Commentary Published on:

  40. Solitary pulmonary nodule (SPN) is a common finding in routine clinical practice when performing chest imaging tests. The vast majority of these nodules are benign, and only a small proportion are malignant. T...

    Authors: Marina Senent-Valero, Julián Librero and María Pastor-Valero
    Citation: Systematic Reviews 2021 10:308
    Content type: Research Published on:

  41. Home visiting services for older adults have been offered for decades to maintain and promote health and independent functioning, thus enhancing quality of life. Previous systematic reviews have provided a mix...

    Authors: Yea Lu Tay, Nurul Salwana Abu Bakar, Ruzimah Tumiran, Noor Hasidah Ab Rahman, Noor Areefa Ameera Mohd Ma’amor, Weng Keong Yau and Zalilah Abdullah
    Citation: Systematic Reviews 2021 10:307
    Content type: Protocol Published on:

  42. There are limited data on the clinical benefits of adding surgical resection in patients with recurrent or metastatic gastrointestinal stromal tumors (GISTs). This protocol outlines the planned scope and metho...

    Authors: Zhaolun Cai, Chunyu Xin, Zhiyuan Jiang, Chunyu Liu, Chaoyong Shen, Guozhen Zhao, Yuan Yin, Xiaonan Yin, Zhou Zhao, Mingchun Mu and Bo Zhang
    Citation: Systematic Reviews 2021 10:306
    Content type: Protocol Published on:

  43. Early onset fetal growth restriction secondary to placental insufficiency can lead to severe maternal and neonatal morbidity and mortality. Pre-clinical studies and a few small randomised clinical trials have ...

    Authors: Jessica Liauw, Katie Groom, Wessel Ganzevoort, Christian Gluud, Christopher J. D. McKinlay, Andrew Sharp, Laura Mackay, Chirag Kariya, Ken Lim, Peter von Dadelszen, Jacqueline Limpens and Janus C. Jakobsen
    Citation: Systematic Reviews 2021 10:305
    Content type: Protocol Published on:

  44. Several resources have been developed (e.g., reporting guidelines) to promote high-standard practices in health research. However, there was no continuous and systematic assessment of recommended practices in ...

    Authors: Nórton Luís Oliveira, Cíntia Ehlers Botton, Angélica Trevisan De Nardi and Daniel Umpierre
    Citation: Systematic Reviews 2021 10:304
    Content type: Research Published on:

  45. Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by persistent deficits in social functioning and the presence of restricted and repetitive behaviours (RRBs). RRBs refer to four subtypes...

    Authors: Tegan Sellick, Alexandra Ure and Katrina Williams
    Citation: Systematic Reviews 2021 10:303
    Content type: Protocol Published on:

  46. The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Depression is a significant complication of T2DM, leading to poor management of T2DM. Thus, early detection and treatment of depression in...

    Authors: Xiaobo Liu, Chao Dong, Hong Jiang, Dongling Zhong, Yuxi Li, Huiling Zhang, Jun Zhang, Jin Fan, Juan Li, Li Guan and Rongjiang Jin
    Citation: Systematic Reviews 2021 10:302
    Content type: Protocol Published on:

  47. The global prevalence of diabetes is nearly 9%, with an upward trend in type 2 diabetes mellitus (T2DM) and gestational diabetes (GDM). Although evidence shows that vulnerable groups are affected disproportion...

    Authors: Jessica Breuing, Christine Joisten, Annika Lena Neuhaus, Simone Heß, Lena Kusche, Fabiola Haas, Mark Spiller and Dawid Pieper
    Citation: Systematic Reviews 2021 10:301
    Content type: Research Published on:

  48. To the best of our knowledge, a scoping review of the published literature investigating the determinants of adult stroke survivors’ reintegration to normal living has not been conducted. This scoping review a...

    Authors: Michael Opeoluwa Ogunlana, Pragashnie Govender, Olufemi Oyeleye Oyewole and Ifeoma Blessing Nwosu
    Citation: Systematic Reviews 2021 10:300
    Content type: Protocol Published on:

  49. The COVID-19 pandemic has devastated the global community with nearly 4.9 million deaths as of October 2021. While organ transplant (OT) recipients (OTr) may be at increased risk for severe COVID-19 due to the...

    Authors: Alexis H. Lerner, Elizabeth J. Klein, Anna Hardesty, Orestis A. Panagiotou, Chelsea Misquith and Dimitrios Farmakiotis
    Citation: Systematic Reviews 2021 10:299
    Content type: Protocol Published on:

  50. Idiopathic pulmonary fibrosis (IPF) is one of the common types of interstitial lung disease having high prevalence and mortality worldwide. As a result of patient-centred hindering factors of adherence to cent...

    Authors: Revati Amin, K. Vaishali, G. Arun Maiya, Aswini Kumar Mohapatra, Uday Narayan Yadav and Shradha S. Parsekar
    Citation: Systematic Reviews 2021 10:297
    Content type: Protocol Published on:
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