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  1. Up to 40% of UDCA-treated patients do not have an adequate clinical response. Farnesoid X receptor agonists, peroxisome proliferator-activated receptor agonists, and fibroblast growth factor 19 analogs were de...

    Authors: Wei Lin, Jun-xi Wang and Yi-juan Liu
    Citation: Systematic Reviews 2024 13:46
  2. Gardening and horticultural therapy (HT) has been widely recognised as a multicomponent approach that has affected a broad range of health and well-being outcomes. The aim of this umbrella review and meta-anal...

    Authors: I. Panțiru, A. Ronaldson, N. Sima, A. Dregan and R. Sima
    Citation: Systematic Reviews 2024 13:45
  3. Since its introduction 25 years ago, the Invisalign® system has undergone multiple digital and biomechanical evolutions and its effectiveness is often compared to traditional systems without considering the ma...

    Authors: Silvia Caruso, Maria Elena De Felice, Chiara Valenti, Stefano Pagano, Sara Caruso, Roberto Gatto and Guido Lombardo
    Citation: Systematic Reviews 2024 13:43
  4. In low-income countries, women with disabilities have limited access to essential sexual and reproductive health services and are disadvantaged socioeconomically. Even though some studies have been conducted p...

    Authors: Abebe Alemu Anshebo, Yilma Markos, Sujit Behera and Natarajan Gopalan
    Citation: Systematic Reviews 2024 13:42
  5. Recent studies have shown that there exists a significant correlation between oral microbiome and the occurrence of malignancies. However, the prognostic significance of oral microbiome for cancer patients rem...

    Authors: Shuluan Li, Tianyu Wang, Ya Ren, Zhou Liu, Jidong Gao and Zhi Guo
    Citation: Systematic Reviews 2024 13:41
  6. A large body of literature indicates that connected speech profiles in patients with Alzheimer’s disease (AD) can be utilized for diagnosis, disease monitoring, and for developing communication strategies for ...

    Authors: Arpita Bose, Samrah Ahmed, Yesi Cheng and Aida Suárez-Gonzalez
    Citation: Systematic Reviews 2024 13:40
  7. Oral mucositis remains a significant complication during cancer therapy with no effective treatment. Gold nanoparticles offer anti-inflammatory, antioxidant properties with low toxicity. This study systematica...

    Authors: Minati Choudhury, Paul Brunton, Donald Schwass, Daniel Pletzer, Jithendra Ratnayake, George Dias and Geoffrey Tompkins
    Citation: Systematic Reviews 2024 13:39
  8. Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repetitive cessation or reduction in airflow during sleep. Stroke patients have a higher risk of OSA, which can worsen their cognitive ...

    Authors: Hualu Yang, Shuya Lu and Lin Yang
    Citation: Systematic Reviews 2024 13:38
  9. Differentiating sepsis from non-infectious systemic inflammatory response syndrome (SIRS) is challenging. Biomarkers like procalcitonin (PCT) aid early risk assessment and guide antibiotic use. This study aims...

    Authors: Hany A. Zaki, Soumaya Bensliman, Khalid Bashir, Haris Iftikhar, Mohamed H. Fayed, Waleed Salem, Amr Elmoheen and Yavuz Yigit
    Citation: Systematic Reviews 2024 13:37
  10. The review aimed to investigate geographic and sociodemographic factors associated with receipt of systemic anticancer therapies (SACT) for women with secondary (metastatic) breast cancer (SBC).

    Authors: Sally Anne Pearson, Sally Taylor, Antonia Marsden, Jessica Dalton O’Reilly, Ashma Krishan, Sacha Howell and Janelle Yorke
    Citation: Systematic Reviews 2024 13:35
  11. Children with autism spectrum disorders are frequent visitors to high technology environments, and their needs may differ from those of their typically developed peers. Procedures in high technology environmen...

    Authors: Emelie Pettersson, Berit Møller Christensen, Ingalill Gimbler Berglund, Elisabeth Nylander and Karina Huus
    Citation: Systematic Reviews 2024 13:34
  12. Systematic review methods are recognized for their rigor and transparency and are widely adapted to frameworks that cover review types such as systematic reviews, scoping reviews, and systematic evidence maps....

    Authors: Vickie R. Walker, Courtney R. Lemeris, Kristen Magnuson, Christopher A. Sibrizzi, Kelly A. Shipkowski, Kyla W. Taylor and Andrew A. Rooney
    Citation: Systematic Reviews 2024 13:33
  13. With the accelerating growth of the academic corpus, doubling every 9 years, machine learning is a promising avenue to make systematic review manageable. Though several notable advancements have already been m...

    Authors: Amirhossein Saeidmehr, Piers David Gareth Steel and Faramarz F. Samavati
    Citation: Systematic Reviews 2024 13:32
  14. Authors: Ana Cristina Beitia Kraemer Moraes, Chiara das Dores do Nascimento, Everton Granemann Souza, Mauricio Beitia Kraemer, Mauricio Moraes, Neftali Lenin Villarreal Carreno, Evandro Piva and Rafael Guerra Lund
    Citation: Systematic Reviews 2024 13:31

    The original article was published in Systematic Reviews 2023 12:236

  15. The interaction between modelers and policymakers is becoming more common due to the increase in computing speed seen in recent decades. The recent pandemic caused by the SARS-CoV-2 virus was no exception. Thu...

    Authors: Oscar Espinosa, Laura Mora, Cristian Sanabria, Antonio Ramos, Duván Rincón, Valeria Bejarano, Jhonathan Rodríguez, Nicolás Barrera, Carlos Álvarez-Moreno, Jorge Cortés, Carlos Saavedra, Adriana Robayo and Oscar H. Franco
    Citation: Systematic Reviews 2024 13:30
  16. Requiring authors to base their research on a systematic review of the existing literature prevents the generation of redundant scientific studies, thereby avoiding the deprivation of effective therapies for t...

    Authors: Diane Rosen, Nils L. Reiter, Barbara Vogel and Robert Prill
    Citation: Systematic Reviews 2024 13:28
  17. Conditions such as hypermobility spectrum disorders (HSD) and Ehlers-Danlos syndrome (EDS) are most often diagnosed when an individual has joint flexibility beyond the normal physiological limits. Additional c...

    Authors: Natalie L. Clark, Melissa Johnson, Amar Rangan, Katherine Swainston and Lucksy Kottam
    Citation: Systematic Reviews 2024 13:27
  18. Female genital mutilation (FGM) has zero health benefits. It can lead to short- and long-term risks and complications, including physical, sexual, and mental health and well-being of girls and women. It is a w...

    Authors: Asteray Assmie Ayenew, Ben W. Mol, Billie Bradford and Gedefaw Abeje
    Citation: Systematic Reviews 2024 13:26
  19. Network meta-analyses (NMAs) have gained popularity and grown in number due to their ability to provide estimates of the comparative effectiveness of multiple treatments for the same condition. The aim of this...

    Authors: Carole Lunny, Areti-angeliki Veroniki, Julian P. T. Higgins, Sofia Dias, Brian Hutton, James M. Wright, Ian R. White, Penny Whiting and Andrea C. Tricco
    Citation: Systematic Reviews 2024 13:25
  20. This systematic review aimed to investigate the relationship between retraction status and the methodology quality in the retracted non-Cochrane systematic review.

    Authors: Azita Shahraki-Mohammadi, Leila Keikha and Razieh Zahedi
    Citation: Systematic Reviews 2024 13:24
  21. Diabetic kidney disease (DKD) is a common and severe complication of diabetes that can lead to end-stage renal disease with no cure. The first-line drugs recommended by clinical guidelines fail to achieve sati...

    Authors: Meifang Liu, Yuan Ming Di, Anthony Lin Zhang, Junhui Chen, Ruobing Wang, Juan Huang, Lei Zhang, Charlie Changli Xue and Xusheng Liu
    Citation: Systematic Reviews 2024 13:23
  22. Tumor budding (TB) is a negative prognostic factor in colorectal cancer; however, its prognostic impact following neoadjuvant therapy for patients with rectal cancer remains unclear. This study aims to assess ...

    Authors: Jinghui Li, Yongli Ma, Liang Wen, Guosheng Zhang, Chengzhi Huang, Junjiang Wang and Xueqing Yao
    Citation: Systematic Reviews 2024 13:22
  23. Critical bleeding events in adults and children with ITP are medical emergencies; however, evidence-based treatment protocols are lacking. Due to the severe thrombocytopenia, (typically platelet count less tha...

    Authors: Emily Sirotich, Hasmik Nazaryan, Saifur Rahman Chowdhury, Gordon Guyatt, Arnav Agarwal, Russell Leong, Aaron Wen, Emily Xu, Bonnie Liu, Sushmitha Pallapothu, Preksha Rathod, Henry Y. Kwon, Jared Dookie, Amirmohammad Shafiee, Jay Charness, Jennifer DiRaimo…
    Citation: Systematic Reviews 2024 13:21
  24. Distal gastrectomy (DG) is a commonly used surgical procedure for gastric cancer (GC), with three reconstruction methods available: Billroth I, Billroth II, and Roux-en-Y. In 2018, our team published a systema...

    Authors: Zhou Zhao, Hancong Li, Xiangcheng Pan, Chaoyong Shen, Mingchun Mu, Xiaonan Yin, Jing Liao, Zhaolun Cai and Bo Zhang
    Citation: Systematic Reviews 2024 13:19
  25. Although the EQ-5D instruments have been initially designed for adult populations, there are new studies evaluating and applying these instruments to children and adolescents. The EuroQol Group adapted and cre...

    Authors: Caique de Melo do Espirito Santo, Verônica Souza Santos, Gisela Cristiane Miyamoto, Alessandro Chiarotto, Marisa Santos and Tiê Parma Yamato
    Citation: Systematic Reviews 2024 13:18
  26. To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening in a primary care setting for hypertension in adults aged 18 years and older. This protocol outlines the scop...

    Authors: Nicole Shaver, Andrew Beck, Alexandria Bennett, Brenda J. Wilson, Chantelle Garritty, Melissa Subnath, Roland Grad, Navindra Persaud, Guylène Thériault, Jennifer Flemming, Brett D. Thombs, John LeBlanc, Janusz Kaczorowski, Peter Liu, Christopher E. Clark, Gregory Traversy…
    Citation: Systematic Reviews 2024 13:17
  27. Addressing childhood stunting is a priority and an important step in the attainment of Global Nutrition Targets for 2025 and Sustainable Development Goals (SDGs). In Rwanda, the prevalence of child stunting re...

    Authors: Chester Kalinda, Maria Albin Qambayot, Sage Marie C. Ishimwe, Denis Regnier, Darius Bazimya, Theogene Uwizeyimana, Samson Desie, Christiane Rudert, Alemayehu Gebremariam, Elizabeth Brennan, Silver Karumba, Rex Wong and Abebe Bekele
    Citation: Systematic Reviews 2024 13:16
  28. Strengthening healthcare systems is a practical approach to enhance healthcare delivery and services. Although there has been a rise in the number of health systems strengthening (HSS) interventions in sub-Sah...

    Authors: Caesar Agula, Ayaga A. Bawah, Patrick O. Asuming, Pearl Kyei and Adriana Biney
    Citation: Systematic Reviews 2024 13:15
  29. The HPV vaccine is characterized by its significant effectiveness in preventing the occurrence of cervical cancer. However, the South Asian countries face multiple challenges in implementing the human papillom...

    Authors: Priyobrat Rajkhowa, Prachi Pundir, Sherize Merlin Dsouza, Divya Sussana Patil, Prakash Narayanan and Helmut Brand
    Citation: Systematic Reviews 2024 13:14
  30. Human ABO blood group type and the antigenic secretor status are hypothesized to associate with oral diseases including oral cancer. Secretor status is the ability of individuals to secrete blood group antigen...

    Authors: T. Walpola, K. L. T. D. Jayawardene and I. Weerasekara
    Citation: Systematic Reviews 2024 13:13
  31. Patient misunderstanding of instructions on medication labels is a common cause of medication errors and can result in ineffective treatment. One way to better improve patient comprehension of medication label...

    Authors: Sara Saif, Tien Thi Thuy Bui, Gyana Srivastava and Yuri Quintana
    Citation: Systematic Reviews 2024 13:12
  32. One concern in meta-analyses is the presence of publication bias (PB) which leads to the dissemination of inflated results. In this study, we assessed how much the meta-analyses in the field of otorhinolaryngo...

    Authors: Fatemeh Mohammadian, Shahin Bastaninejad and Shirin Irani
    Citation: Systematic Reviews 2024 13:11
  33. It is controversial whether the level of glycemic control in patients with type 1 diabetes mellitus (T1DM) correlates with reduced cognitive function. This study explored the influence of glycemic management q...

    Authors: Wenting Hua, Zouxi Du, Tingting Lu and Limin Tian
    Citation: Systematic Reviews 2024 13:10
  34. Intravenous iron (IV-iron) is used as an alternative to, or alongside, red blood cell transfusion (RBC-T) to treat more severe postpartum anemia (PPA), although optimal treatment options remain unclear. No pre...

    Authors: E. Caljé, K. M. Groom, L. Dixon, J. Marriott, R. Foon, C. Oyston, F. H. Bloomfield and V. Jordan
    Citation: Systematic Reviews 2024 13:9
  35. Research that examines the intersections of Indigenous Peoples’ health and wellbeing with climate change and biodiversity loss is abundant in the global scholarship. A synthesis of this evidence base is crucia...

    Authors: Laura Jane Brubacher, Tara Tai-Wen Chen, Sheri Longboat, Warren Dodd, Laura Peach, Susan J. Elliott, Kaitlyn Patterson and Hannah Neufeld
    Citation: Systematic Reviews 2024 13:8
  36. Robust, relevant, comprehensive, and up-to-date evidence syntheses are the cornerstone for evidence-informed healthcare decisions. When considering multiple treatment options, network meta-analysis (NMA) syste...

    Authors: Anke Rohwer, Veranyuy Ngah, Dimitris Mavridis, Taryn Young and Michael McCaul
    Citation: Systematic Reviews 2024 13:7
  37. Iron deficiency (ID) is the leading cause of anemia worldwide. The prevalence of preoperative ID ranges from 23 to 33%. Preoperative anemia is associated with worse outcomes, making it important to diagnose an...

    Authors: Stephanie Stangl, Maria Popp, Stefanie Reis, Magdalena Sitter, Lena Saal-Bauernschubert, Selina Schießer, Peter Kranke, Suma Choorapoikayil, Stephanie Weibel and Patrick Meybohm
    Citation: Systematic Reviews 2024 13:5
  38. Deoxyribonucleic acid (DNA) methylation is one of the epigenetic modifications that has gained a lot of interest as a factor influencing fetal programming and as a biomarker for adverse pregnancy and birth out...

    Authors: Innocent Moagi, Lawrence Mabasa, Sonto Maria Maputle, Duduzile Ndwandwe, Ndidzulafhi Selina Raliphaswa, Lizzy Mutshinyalo Netshikweta, Thivhulawi Malwela and Amidou Samie
    Citation: Systematic Reviews 2024 13:4
  39. Quality measurement as part of quality improvement in healthcare is integral for service delivery and development. This is particularly pertinent for health services that deliver care in ways that differ from ...

    Authors: Jamie Scott, Libby Thomas, Tony Joy and Paddy McCrossan
    Citation: Systematic Reviews 2024 13:3
  40. Equitable sex- and gender-based representation in clinical trials is an essential step to ensuring evidence-based care for women. While multi-institutional actions have led to significant improvements in the i...

    Authors: Karen M. Goldstein, Lindsay Chi Yan Kung, Susan Alton Dailey, Aimee Kroll-Desrosiers, Colleen Burke, Megan Shepherd-Banigan, Rebecca Lumsden, Catherine Sims, Julie Schexnayder, Dhara Patel, Sarah Cantrell, Kate L. Sheahan and Jennifer M. Gierisch
    Citation: Systematic Reviews 2024 13:2
  41. Authors: Powsiga Uruthirakumar, Rajendra Surenthirakumaran, Tiffany E. Gooden, Gregory Y. H. Lip, G. Neil Thomas, David J. Moore, Krishnarajah Nirantharakumar, Balachandran Kumarendran, Kumaran Subaschandran, Shribavan Kaneshamoorthy, Vethanayagam Antony Sheron and Mahesan Guruparan
    Citation: Systematic Reviews 2023 12:241

    The original article was published in Systematic Reviews 2023 12:52

  42. Sensitive, robust, and fast point-of-care tests are needed for cutaneous leishmaniasis (CL) diagnosis. The recently developed CL Detect rapid test (InBios) for detecting Leishmania peroxidoxin antigen has been ev...

    Authors: Behailu Taye Gebremeskele, Gashaw Adane, Mohammed Adem and Fitsumbrhan Tajebe
    Citation: Systematic Reviews 2023 12:240
  43. A bibliometric review of the biomedical literature could be essential in synthesizing evidence if thoroughly conducted and documented. Although very similar to review papers in nature, it slightly differs in s...

    Authors: Ali Montazeri, Samira Mohammadi, Parisa M.Hesari, Marjan Ghaemi, Hedyeh Riazi and Zahra Sheikhi-Mobarakeh
    Citation: Systematic Reviews 2023 12:239
  44. College students who experience the negative impact of poverty, such as food, financial, and housing insecurity, are at higher risk for poor academic performance. One recent study examined grief in a college s...

    Authors: Sarah Elizabeth Garza-Levitt, Mary M. McFarland, Kimberly Ponce Gonzalez and Katherine P. Supiano
    Citation: Systematic Reviews 2023 12:235

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