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  1. Content type: Protocol

    When patients have been on opioid therapy for more than 90 days, more than half of them continue using opioids years later. Knowing that long-term opioid consumption could lead to harmful side effects includin...

    Authors: M. Gabrielle Pagé, Irina Kudrina, Hervé Tchala Vignon Zomahoun, Daniela Ziegler, Pierre Beaulieu, Céline Charbonneau, Jennifer Cogan, Raoul Daoust, Marc O. Martel, Andrée Néron, Philippe Richebé and Hance Clarke

    Citation: Systematic Reviews 2018 7:97

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  2. Content type: Protocol

    ‘Pain rewarded’ is a hypothesis wherein acute pain sufferers are exposed to reinforcers and punishers from their environment that shape their behaviour, i.e. pain responses. Such a point of view has been taken...

    Authors: Wacław M. Adamczyk, Kerstin Luedtke, Ewa Buglewicz and Przemysław Bąbel

    Citation: Systematic Reviews 2018 7:93

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  3. Content type: Protocol

    As general population life expectancy has increased, the need to investigate the quality of life has arisen, especially because it is important that people have a healthy long life and with good quality. Studi...

    Authors: Janete Capel Hernandes, Viviane Cruvinel Di Castro, Mauro Elias Mendonça and Celmo Celeno Porto

    Citation: Systematic Reviews 2018 7:92

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  4. Content type: Protocol

    Neoadjuvant chemotherapy (NACT), a standard of care for locally advanced breast cancer patients, is widely used for early breast cancer patients also. The varying role of regimens used as NACT needs to be inve...

    Authors: Mona Pathak, Sada Nand Dwivedi, S. V. S. Deo, Bhaskar Thakur, Vishnubhatla Sreenivas and G. K. Rath

    Citation: Systematic Reviews 2018 7:89

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  5. Content type: Protocol

    Individuals with substance use and addictive disorders often display greater risk-taking behaviour, higher impulsivity, and altered reward processing compared to individuals without these disorders. While it i...

    Authors: Katherine R. Naish, Lana Vedelago, James MacKillop and Michael Amlung

    Citation: Systematic Reviews 2018 7:90

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  6. Content type: Protocol

    Dementia is a globally prevalent disease that requires ongoing and increasing levels of care, often provided in the first instance by informal caregivers. Supporting transitions in informal caregiving in demen...

    Authors: Marianne Cranwell, Anna Gavine, Linda McSwiggan and Timothy B. Kelly

    Citation: Systematic Reviews 2018 7:91

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  7. Content type: Protocol

    Menu labelling is continuing to gather public and legislative support as one of the potential environmental strategies for addressing the obesity pandemic. However, issues relating to implementation have been ...

    Authors: Claire Kerins, Jennifer McSharry, Catherine Hayes, Ivan J. Perry, Fiona Geaney and Colette Kelly

    Citation: Systematic Reviews 2018 7:88

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  8. Content type: Editorial

    The journal recently celebrated its fifth anniversary. Like systematic reviews themselves, the journal is thriving and publishing a variety of protocols, reviews, and methods papers. We have also had success i...

    Authors: David Moher, Lesley A. Stewart and Paul Shekelle

    Citation: Systematic Reviews 2018 7:87

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  9. Content type: Protocol

    Meningococcal disease (MD) is notoriously difficult to diagnose in the early stages of the illness and presents similarly to many self-limiting viral infections. This mandates a cautious approach to diagnosis ...

    Authors: Thomas Waterfield, Derek Fairley, Fiona Lynn, Bronagh Blackwood and Michael D. Shields

    Citation: Systematic Reviews 2018 7:86

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  10. Content type: Research

    Self-management support interventions may potentially delay kidney function decline and associated complications in patients with comorbid diabetes and chronic kidney disease. However, the effectiveness of the...

    Authors: Edward Zimbudzi, Clement Lo, Marie L. Misso, Sanjeeva Ranasinha, Peter G. Kerr, Helena J. Teede and Sophia Zoungas

    Citation: Systematic Reviews 2018 7:84

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  11. Content type: Protocol

    Systematic reviews (SRs) of randomised controlled trials (RCTs) can provide the best evidence to inform decision-making, but their methodological and reporting quality varies. Tools exist to guide the critical...

    Authors: Allison Gates, Michelle Gates, Gonçalo Duarte, Maria Cary, Monika Becker, Barbara Prediger, Ben Vandermeer, Ricardo M. Fernandes, Dawid Pieper and Lisa Hartling

    Citation: Systematic Reviews 2018 7:85

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  12. Content type: Protocol

    Non-infectious uveitis represents a sub-type of intraocular inflammation often associated with disorders of immune dysregulation. If untreated, the intraocular inflammation may progress to severe visual impair...

    Authors: Joshua Blair, Robert Barry, Philip I. Murray, David J. Moore and Alastair K. Denniston

    Citation: Systematic Reviews 2018 7:83

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  13. Content type: Research

    Early diagnosis of human immunodeficiency virus (HIV) is important because antiretroviral therapies are more effective if infected individuals are diagnosed early. Diagnosis of HIV relies on laboratory testing...

    Authors: Benhildah N. Rumbwere Dube, Tom P. Marshall, Ronan P. Ryan and Modupe Omonijo

    Citation: Systematic Reviews 2018 7:82

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  14. Content type: Research

    Anemia continued to become a major public health problem in developing nations including Ethiopia. Especially, school children are more vulnerable for anemia and consequences of anemia. Generating accurate epi...

    Authors: Robel Tezera, Zekariyas Sahile, Delelegn Yilma, Equilnet Misganaw and Ermiyas Mulu

    Citation: Systematic Reviews 2018 7:80

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  15. Content type: Protocol

    Of various chronic diseases, low back pain (LBP) is the most common and debilitating musculoskeletal condition among older adults aged 65 years or older. While more than 17 million older adults in the USA suff...

    Authors: Arnold Y. L. Wong, Katarina Sjögren Forss, Jenny Jakobsson, Veronika Schoeb, Christine Kumlien and Gunilla Borglin

    Citation: Systematic Reviews 2018 7:81

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  16. Content type: Protocol

    Conducting a health technology assessment (HTA) of public health interventions (PHIs) poses some challenges. PHIs are often complex interventions, which affect the number and degree of interactions of the aspe...

    Authors: Tim Mathes, Gerald Willms, Stephanie Polus, Constance Stegbauer, Melanie Messer, Corinna Klingler, Heidi Ehrenreich, Dea Niebuhr, Georg Marckmann, Ansgar Gerhardus and Dawid Pieper

    Citation: Systematic Reviews 2018 7:79

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  17. Content type: Protocol

    Needle-related procedures are the most important source of pain in children in hospital setting. Unmanaged pain could result in short- and long-term physiological, psychological, and emotional consequences. Al...

    Authors: Ariane Ballard, Christelle Khadra, Samara Adler, Evelyne Doyon-Trottier and Sylvie Le May

    Citation: Systematic Reviews 2018 7:78

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  18. Content type: Protocol

    Adult brachial plexus injuries (BPI) are becoming more common. The reconstruction and prognosis of pre-ganglionic injuries (root avulsions) are different to other types of BPI injury. Preoperative magnetic res...

    Authors: Ryckie G. Wade, Yemisi Takwoingi, Justin C. R. Wormald, John P. Ridgway, Steven Tanner, James J. Rankine and Grainne Bourke

    Citation: Systematic Reviews 2018 7:76

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  19. Content type: Commentary

    Systematic reviews (SR) are vital to health care, but have become complicated and time-consuming, due to the rapid expansion of evidence to be synthesised. Fortunately, many tasks of systematic reviews have th...

    Authors: Elaine Beller, Justin Clark, Guy Tsafnat, Clive Adams, Heinz Diehl, Hans Lund, Mourad Ouzzani, Kristina Thayer, James Thomas, Tari Turner, Jun Xia, Karen Robinson and Paul Glasziou

    Citation: Systematic Reviews 2018 7:77

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  20. Content type: Protocol

    There will be a lack of 18 million healthcare workers by 2030. Multiplying the number of well-trained healthcare workers through innovative ways such as eLearning is highly recommended in solving this shortage...

    Authors: Gloria C. Law, Christian Apfelbacher, Pawel P. Posadzki, Sandra Kemp and Lorainne Tudor Car

    Citation: Systematic Reviews 2018 7:75

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  21. Content type: Protocol

    Hearing loss is one of the leading causes of disability worldwide, with greater than 20% of Canadian adults having measurable hearing loss in at least one ear. Patients with hearing loss experience impaired qu...

    Authors: Nadera Ahmadzai, Shaun Kilty, Dianna Wolfe, Jamie Bonaparte, David Schramm, Elizabeth Fitzpatrick, Vincent Lin, Wei Cheng, Becky Skidmore, David Moher and Brian Hutton

    Citation: Systematic Reviews 2018 7:74

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  22. Content type: Research

    Organizational contextual features have been recognized as important determinants for implementing evidence-based practices across healthcare settings for over a decade. However, implementation scientists have...

    Authors: Shelly-Anne Li, Lianne Jeffs, Melanie Barwick and Bonnie Stevens

    Citation: Systematic Reviews 2018 7:72

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  23. Content type: Protocol

    Exertional lower body musculoskeletal injuries (ELBI) cost billions of dollars and compromise the readiness and job performance of military service and public safety workers (i.e., tactical populations). The p...

    Authors: Shawn D. Flanagan, Aaron M. Sinnott, Kellen T. Krajewski, Caleb D. Johnson, Shawn R. Eagle, Alice D. LaGoy, Meaghan E. Beckner, Anne Z. Beethe, Rose Turner, Mita Lovalekar, Courtenay Dunn-Lewis, Chris Connaboy and Bradley C. Nindl

    Citation: Systematic Reviews 2018 7:73

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  24. Content type: Research

    Pharmacist counselling is an important service that has been associated with improved outcomes. The primary aim of this review was to identify, describe, and determine the effectiveness of interventions for im...

    Authors: Sinaa Al Aqeel, Norah Abanmy, Hiba AlShaya and Albatoul Almeshari

    Citation: Systematic Reviews 2018 7:71

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  25. Content type: Research

    Health information is readily accessible but is of variable quality. General knowledge about how to assess whether claims about health interventions are trustworthy is not common, so people’s health decisions ...

    Authors: Leila Cusack, Chris B. Del Mar, Iain Chalmers, Elizabeth Gibson and Tammy C. Hoffmann

    Citation: Systematic Reviews 2018 7:68

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  26. Content type: Protocol

    Cryptosporidium is a protozoan parasite of humans and other animals worldwide and is one of the greatest contributors to human diarrhoeal illness. Transmission can occur indirectly via contaminated food or water,...

    Authors: Caoimhe McKerr, Sarah J. O’Brien, Rachel M. Chalmers, Roberto Vivancos and Robert M. Christley

    Citation: Systematic Reviews 2018 7:70

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  27. Content type: Protocol

    To investigate the use of physical activity monitors (PAMs) for the elderly, the scientific literature should be systematically reviewed and the effect quantified, as the evidence seems inconclusive.

    Authors: Rasmus Tolstrup Larsen, Jan Christensen, Carsten Bogh Juhl, Henning Boje Andersen and Henning Langberg

    Citation: Systematic Reviews 2018 7:69

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  28. Content type: Protocol

    People with a mental illness experience a higher morbidity and mortality from chronic diseases relative to the general population. A higher prevalence of risk behaviours, including tobacco smoking, poor nutrit...

    Authors: Caitlin Fehily, Kate Bartlem, John Wiggers, Luke Wolfenden, Timothy Regan, Julia Dray, Jacqueline Bailey and Jenny Bowman

    Citation: Systematic Reviews 2018 7:67

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  29. Content type: Protocol

    Implementation science is the study of strategies used to integrate evidence-based practices into real-world settings (Eccles and Mittman, Implement Sci. 1(1):1, 2006). Central to the identification of replica...

    Authors: Cara C. Lewis, Kayne D. Mettert, Caitlin N. Dorsey, Ruben G. Martinez, Bryan J. Weiner, Elspeth Nolen, Cameo Stanick, Heather Halko and Byron J. Powell

    Citation: Systematic Reviews 2018 7:66

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  30. Content type: Protocol

    Transportation interventions seek to decrease delay in reaching a health facility for emergency obstetric care and are, thus, believed to contribute to reductions in such adverse pregnancy and childbirth outco...

    Authors: John Ehiri, Halimatou Alaofè, Ibitola Asaolu, Joy Chebet, Ekpereonne Esu and Martin Meremikwu

    Citation: Systematic Reviews 2018 7:65

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  31. Content type: Research

    Previous research shows that many authors of Cochrane overviews were also involved in some of the included systematic reviews (SRs). This type of dual (co-)authorship (DCA) may be a conflict of interest and a ...

    Authors: Dawid Pieper, Andreas Waltering, Jakob Holstiege and Roland Brian Büchter

    Citation: Systematic Reviews 2018 7:63

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  32. Content type: Protocol

    In the context of rising dementia prevalence, the workload of general practitioners (GPs) in dementia care is set to increase. However, there are many aspects of dementia care that GPs find challenging. Behavi...

    Authors: Aisling A. Jennings, Tony Foley, Kieran A. Walsh, Alice Coffey, John P. Browne and Colin P. Bradley

    Citation: Systematic Reviews 2018 7:62

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  33. Content type: Protocol

    Three types of central venous access devices (CVADs)—peripherally inserted central catheters (PICCs), skin-tunnelled central catheters (Hickman-type devices), and implantable chest wall Ports (Ports)—are routi...

    Authors: Caoimhe Ryan, Hannah Hesselgreaves, Olivia Wu, Jim Paul, Judith Dixon-Hughes and Jonathan G. Moss

    Citation: Systematic Reviews 2018 7:61

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  34. Content type: Protocol

    Nearly 15% of all pregnancies end in fatal perinatal obstetric complications including bleeding, infections, hypertension, obstructed labor, and complications of abortion. Between 1990 and 2015, an estimated 1...

    Authors: Ayele Geleto, Catherine Chojenta, Abdulbasit Mussa and Deborah Loxton

    Citation: Systematic Reviews 2018 7:60

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  35. Content type: Research

    We investigated whether information in would impact the conclusions of five ongoing systematic reviews.

    Authors: Gaelen P. Adam, Stacey Springs, Thomas Trikalinos, John W. Williams Jr, Jennifer L. Eaton, Megan Von Isenburg, Jennifer M. Gierisch, Lisa M. Wilson, Karen A. Robinson, Meera Viswanathan, Jennifer Cook Middleton, Valerie L. Forman-Hoffman, Elise Berliner and Robert M. Kaplan

    Citation: Systematic Reviews 2018 7:59

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  36. Content type: Protocol

    Mid-portion Achilles tendinopathy (AT) is prevalent amongst athletic and non-athletic populations with pain, stiffness and impaired function typically reported. While different management options exist, loadin...

    Authors: Myles Murphy, Mervyn Travers and William Gibson

    Citation: Systematic Reviews 2018 7:58

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  37. Content type: Protocol

    Depression and anxiety symptoms are reported to be common among university students in many regions of the world and impact on quality of life and academic attainment. The extent of the problem of depression a...

    Authors: James January, Munyaradzi Madhombiro, Shalote Chipamaunga, Sunanda Ray, Alfred Chingono and Melanie Abas

    Citation: Systematic Reviews 2018 7:57

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  38. Content type: Protocol

    Despite a decline in child and adult smoking prevalence, young people who smoke (even occasionally) can rapidly become addicted to nicotine, with most adult smokers initiating smoking before they are 18. Schoo...

    Authors: Fiona Dobbie, Kathryn Angus, Hannah Littlecott, Karen Allum, Valerie Wells, Amanda Amos, Sally Haw and Linda Bauld

    Citation: Systematic Reviews 2018 7:56

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  39. Content type: Protocol

    The Sustainable Development Goal (SDG) 3 emphasises on reducing neonatal deaths caused by low birth weight (LBW) complications by the implementation and utilisation of Kangaroo Mother Care (KMC) in low- and mi...

    Authors: Christina T. Mathias, Solange Mianda and Themba G. Ginindza

    Citation: Systematic Reviews 2018 7:55

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  40. Content type: Protocol

    Caring for patients with subarachnoid hemorrhage (SAH) presents unique challenges, due in part to the severity of the underlying insult, competing systemic injuries, and unpredictable clinical course. Even whe...

    Authors: Shaurya Taran, Vatsal Trivedi, Jeffrey M. Singh, Shane W. English and Victoria A. McCredie

    Citation: Systematic Reviews 2018 7:53

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  41. Content type: Protocol

    Childhood obesity is a major global public health problem, with governments increasingly having to undertake various strategies to reduce excess weight in their populations. Considering the increasing number o...

    Authors: Mandana Zanganeh, Peymane Adab, Bai Li and Emma Frew

    Citation: Systematic Reviews 2018 7:54

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  42. Content type: Protocol

    Heart failure (HF) in pediatric populations is a major public health concern. It is associated with high rates of hospital admissions, disability, and mortality in high-income countries (HIC), but its burden i...

    Authors: Aurélie T. Sibetcheu, Valirie Ndip Agbor, Ulrich Flore Nyaga, Jean Joël Bigna and Jean Jacques Noubiap

    Citation: Systematic Reviews 2018 7:52

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  43. Content type: Protocol

    There is heterogeneity among obese individuals, as some appear to have healthier metabolic profiles and decreased health risks. These individuals are defined as metabolically healthy obese (MHO), whilst those ...

    Authors: E. M. Robson, S. Costa, M. Hamer and W. Johnson

    Citation: Systematic Reviews 2018 7:50

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  44. Content type: Protocol

    The high impact of a cancer diagnosis on patients and their families and the increasing costs of cancer treatment call for optimal and efficient oncological care. To improve the quality of care and to minimize...

    Authors: Jolanda C. van Hoeve, Robin W. M. Vernooij, Adegboyega K. Lawal, Michelle Fiander, Peter Nieboer, Sabine Siesling and Thomas Rotter

    Citation: Systematic Reviews 2018 7:49

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  45. Content type: Correction

    The correct title of the article [1] should be “Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol”.

    Authors: Evan Mayo-Wilson, Susan Hutfless, Tianjing Li, Gillian Gresham, Nicole Fusco, Jeffrey Ehmsen, James Heyward, Swaroop Vedula, Diana Lock, Jennifer Haythornthwaite, Jennifer L. Payne, Theresa Cowley, Elizabeth Tolbert, Lori Rosman, Claire Twose, Elizabeth A. Stuart…

    Citation: Systematic Reviews 2018 7:48

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    The original article was published in Systematic Reviews 2015 4:143

  46. Content type: Protocol

    Pre-exposure prophylaxis (PrEP) with antiretrovirals is an efficacious and effective intervention to decrease the risk of HIV (human immunodeficiency virus) acquisition. Yet drug and delivery costs prohibit ac...

    Authors: Kednapa Thavorn, Howsikan Kugathasan, Darrell H. S. Tan, Nasheed Moqueet, Stefan D. Baral, Becky Skidmore, Derek MacFadden, Anna Simkin and Sharmistha Mishra

    Citation: Systematic Reviews 2018 7:47

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  47. Content type: Protocol

    DNA methylation (global and gene-specific) has been reported as an epigenetic mechanism that could be involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Furthermore, epigenetic therapy has been s...

    Authors: Tinashe Mutize, Zibusiso Mkandla and Bongani B. Nkambule

    Citation: Systematic Reviews 2018 7:46

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  48. Content type: Protocol

    Technology has been implemented since the 1970s with the hope of improving glycaemic control and reducing the burden of complications for those living with type 1 diabetes. A clinical and cost-effectiveness co...

    Authors: Anthony Pease, Clement Lo, Arul Earnest, Danny Liew and Sophia Zoungas

    Citation: Systematic Reviews 2018 7:44

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