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  1. Systematic reviewers are increasingly trying to obtain regulatory clinical study reports (CSRs) to correct for publication bias. For instance, our organization, the Institute for Quality and Efficiency in Heal...

    Authors: Beate Wieseler, Natalie McGauran, Michaela F Kerekes and Thomas Kaiser

    Citation: Systematic Reviews 2012 1:50

    Content type: Commentary

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  2. Accessible sexual, reproductive, and mental healthcare services are crucial for adolescent health and wellbeing. It has been reported that school-based healthcare (SBHC) has the potential to improve the availa...

    Authors: Amanda J Mason-Jones, Carolyn Crisp, Mariette Momberg, Joy Koech, Petra De Koker and Cathy Mathews

    Citation: Systematic Reviews 2012 1:49

    Content type: Research

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  3. School-based interventions and campaigns are used to promote health and address a wide variety of public health problems. Schools are considered to be key sites for the implementation of health promotion progr...

    Authors: Mark Pearson, Roy Chilton, Helen B Woods, Katrina Wyatt, Tamsin Ford, Charles Abraham and Rob Anderson

    Citation: Systematic Reviews 2012 1:48

    Content type: Protocol

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  4. Diabetes and increased age are known risk factors for physical disability. With the increasing prevalence of diabetes within our aging population, the future burden of disability is expected to increase. To da...

    Authors: Evelyn Wong, Kathryn Backholer, Jessica Harding, Emma Gearon, Christopher Stevenson, Rosanne Freak-Poli and Anna Peeters

    Citation: Systematic Reviews 2012 1:47

    Content type: Protocol

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  5. Co-morbid symptoms (for example, chronic pain, depression, anxiety, and fatigue) are particularly common in military fighters returning from the current conflicts, who have experienced physical and/or psycholo...

    Authors: Courtney Lee, Cindy Crawford, Dawn Wallerstedt, Alexandra York, Alaine Duncan, Jennifer Smith, Meredith Sprengel, Richard Welton and Wayne Jonas

    Citation: Systematic Reviews 2012 1:46

    Content type: Research

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  6. Older adults experience activity and participation limitations that are associated with ageing. Activity and participation limitations affect an older adult’s ability to engage in meaningful daily activities a...

    Authors: Kylie Wales, Lindy Clemson, Natasha A Lannin and Ian D Cameron

    Citation: Systematic Reviews 2012 1:45

    Content type: Protocol

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  7. Many drugs and treatments given to patients for various reasons affect their weight. This side effect is of great importance to patients and is also a concern for the treating physician because weight change m...

    Authors: Juan Pablo Domecq, Gabriela Prutsky, Zhen Wang, Tarig Elraiyah, Juan Pablo Brito, Karen Mauck, Mohammed H Lababidi, Aaron Leppin, Salman Fidahussein, Larry J Prokop, Victor M Montori and Mohammad H Murad

    Citation: Systematic Reviews 2012 1:44

    Content type: Protocol

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  8. All randomized clinical trials (RCTs) require a protocol; however, numerous studies have highlighted protocol deficiencies. Reporting guidelines may improve the content of research reports and, if developed us...

    Authors: Jennifer M Tetzlaff, An-Wen Chan, Jessica Kitchen, Margaret Sampson, Andrea C Tricco and David Moher

    Citation: Systematic Reviews 2012 1:43

    Content type: Research

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  9. The role of intravascular ultrasound (IVUS) in percutaneous coronary interventions (PCI) is still controversial despite several previously published meta-analyses. A meta-analysis to evaluate the controversial...

    Authors: Lucas Lodi-Junqueira, Marcos Roberto de Sousa, Leonardo Carvalho da Paixão, Silvana Márcia Bruschi Kelles, Carlos Faria Santos Amaral and Antonio L Ribeiro

    Citation: Systematic Reviews 2012 1:42

    Content type: Research

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  10. Network meta-analysis is becoming increasingly popular for establishing comparative effectiveness among multiple interventions for the same disease. Network meta-analysis inherits all methodological challenges...

    Authors: Kristian Thorlund and Edward J Mills

    Citation: Systematic Reviews 2012 1:41

    Content type: Methodology

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  11. Perioperative pain management has recently been revolutionized with the recognition of novel mechanisms and introduction of newer drugs. Many randomized trials have studied the use of the gabapentinoid anti-ep...

    Authors: Naveen Eipe, John Penning, Mohammed Ansari, Fatemeh Yazdi and Nadera Ahmadzai

    Citation: Systematic Reviews 2012 1:40

    Content type: Protocol

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  12. Recent developments related to a safe and effective nonabsorbable antibiotic, rifaximin, and identification of postinfectious irritable bowel syndrome as a frequent sequela call for a need to reconsider the va...

    Authors: Sanjin Alajbegovic, John W Sanders, Deborah E Atherly and Mark S Riddle

    Citation: Systematic Reviews 2012 1:39

    Content type: Research

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  14. Systematic reviews are promoted as being important to inform decision-making. However, when presented with a set of reviews in a complex area, how easy is it to understand how and why they may differ from one ...

    Authors: Jenny Woodman, James Thomas and Kelly Dickson

    Citation: Systematic Reviews 2012 1:37

    Content type: Research

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  15. The purpose of this project was to conduct an overview of existing systematic reviews to evaluate the effectiveness of reminders in changing professional behavior in clinical settings.

    Authors: Amy Cheung, Michelle Weir, Alain Mayhew, Nicole Kozloff, Kaitlyn Brown and Jeremy Grimshaw

    Citation: Systematic Reviews 2012 1:36

    Content type: Systematic review update

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  16. Influenza vaccines are most effective when the antigens in the vaccine match those of circulating influenza strains. The extent to which the vaccine is protective when circulating strains differ from vaccine a...

    Authors: Andrea C Tricco, Ayman Chit, David Hallett, Charlene Soobiah, Genevieve Meier, Maggie Chen, Mariam Tashkandi, Chris Bauch and Mark Loeb

    Citation: Systematic Reviews 2012 1:35

    Content type: Protocol

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  18. Hyperprolactinemia is a common endocrine disorder that can be associated with significant morbidity. We conducted a systematic review and meta-analyses of outcomes of hyperprolactinemic patients, including mic...

    Authors: Amy T Wang, Rebecca J Mullan, Melanie A Lane, Ahmad Hazem, Chaithra Prasad, Nicola W Gathaiya, M Mercè Fernández-Balsells, Amy Bagatto, Fernando Coto-Yglesias, Jantey Carey, Tarig A Elraiyah, Patricia J Erwin, Gunjan Y Gandhi, Victor M Montori and Mohammad Hassan Murad

    Citation: Systematic Reviews 2012 1:33

    Content type: Research

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  20. Approximately 35 million people world-wide have Alzheimer’s disease and this is projected to nearly double by 2030. Cognitive enhancers, including cholinesterase inhibitors (for example, donepezil, galantamine...

    Authors: Andrea C Tricco, Sondra vanderVaart, Charlene Soobiah, Erin Lillie, Laure Perrier, Maggie H Chen, Brenda Hemmelgarn, Sumit R Majumdar and Sharon E Straus

    Citation: Systematic Reviews 2012 1:31

    Content type: Protocol

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  21. High rates of childhood maltreatment have been documented in HIV-positive men and women. In addition, mental disorders are highly prevalent in both HIV-infected individuals and victims of childhood maltreatmen...

    Authors: Georgina Spies, Tracie O Afifi, Sarah L Archibald, Christine Fennema-Notestine, Jitender Sareen and Soraya Seedat

    Citation: Systematic Reviews 2012 1:30

    Content type: Research

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  23. This paper argues that the current proliferation of types of systematic reviews creates challenges for the terminology for describing such reviews. Terminology is necessary for planning, describing, appraising...

    Authors: David Gough, James Thomas and Sandy Oliver

    Citation: Systematic Reviews 2012 1:28

    Content type: Commentary

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  24. Canada’s diverse society and statutory commitment to multiculturalism means that the synthesis of knowledge related to the health care experiences of immigrants is essential to realize the health potential for...

    Authors: Gina M A Higginbottom, Myfanwy Morgan, Jayantha Dassanayake, Helgi Eyford, Mirande Alexandre, Yvonne Chiu, Joan Forgeron and Deb Kocay

    Citation: Systematic Reviews 2012 1:27

    Content type: Protocol

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  25. The objective of this systematic review was to examine the benefits, harms and pharmacokinetic interactions arising from the co-administration of commonly used dietary supplements with cardiovascular drugs. Ma...

    Authors: Salmaan Kanji, Dugald Seely, Fatemeh Yazdi, Jennifer Tetzlaff, Kavita Singh, Alexander Tsertsvadze, Andrea C Tricco, Margaret E Sears, Teik C Ooi, Michele A Turek, Becky Skidmore and Mohammed T Ansari

    Citation: Systematic Reviews 2012 1:26

    Content type: Research

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  26. Elderly individuals who have memory problems without significant limitations in activities of daily living are often diagnosed as having mild cognitive impairment (MCI). Some of these individuals progress to d...

    Authors: Andrea C Tricco, Charlene Soobiah, Erin Lillie, Laure Perrier, Maggie H Chen, Brenda Hemmelgarn, Sumit R Majumdar and Sharon E Straus

    Citation: Systematic Reviews 2012 1:25

    Content type: Protocol

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  27. Reporting of health research is often inadequate and incomplete. Complete and transparent reporting is imperative to enable readers to assess the validity of research findings for use in healthcare and policy ...

    Authors: Larissa Shamseer, Adrienne Stevens, Becky Skidmore, Lucy Turner, Douglas G Altman, Allison Hirst, John Hoey, Anita Palepu, Iveta Simera, Kenneth Schulz and David Moher

    Citation: Systematic Reviews 2012 1:24

    Content type: Protocol

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  28. In April 2005, researchers based at the Medical Research Council Clinical Trials Unit, set out to involve women affected by cervical cancer in a systematic review and meta-analysis of individual patient data t...

    Authors: Claire L Vale, Jayne F Tierney, Nicolette Spera, Andrea Whelan, Alison Nightingale and Bec Hanley

    Citation: Systematic Reviews 2012 1:23

    Content type: Research

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  29. There is a significant public health burden associated with substance use in Canada. The early detection and/or treatment of risky substance use has the potential to dramatically improve outcomes for those who...

    Authors: Matthew M Young, Adrienne Stevens, Amy Porath-Waller, Tyler Pirie, Chantelle Garritty, Becky Skidmore, Lucy Turner, Cheryl Arratoon, Nancy Haley, Karen Leslie, Rhoda Reardon, Beth Sproule, Jeremy Grimshaw and David Moher

    Citation: Systematic Reviews 2012 1:22

    Content type: Protocol

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  31. Obstructive sleep apnea is a relatively common disorder that can lead to lost productivity and cardiovascular disease. The form of positive airway treatment that should be offered is unclear.

    Authors: Stanley Ip, Carolyn D'Ambrosio, Kamal Patel, Ndidiamaka Obadan, Georgios D Kitsios, Mei Chung and Ethan M Balk

    Citation: Systematic Reviews 2012 1:20

    Content type: Research

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  32. Over the past few years, information retrieval has become more and more professionalized, and information specialists are considered full members of a research team conducting systematic reviews. Research grou...

    Authors: Elke Hausner, Siw Waffenschmidt, Thomas Kaiser and Michael Simon

    Citation: Systematic Reviews 2012 1:19

    Content type: Methodology

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  33. In meta-regression, as the number of trials in the analyses decreases, the risk of false positives or false negatives increases. This is partly due to the assumption of normality that may not hold in small sam...

    Authors: Joel J Gagnier, David Moher, Heather Boon, Claire Bombardier and Joseph Beyene

    Citation: Systematic Reviews 2012 1:18

    Content type: Methodology

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  34. Mild traumatic brain injury (MTBI) is a major public-health concern and represents 70-90% of all treated traumatic brain injuries. The last best-evidence synthesis, conducted by the WHO Collaborating Centre fo...

    Authors: Carol Cancelliere, J David Cassidy, Pierre Côté, Cesar A Hincapié, Jan Hartvigsen, Linda J Carroll, Connie Marras, Eleanor Boyle, Vicki Kristman, Ryan Hung, Britt-Marie Stålnacke, Peter Rumney, Victor Coronado, Lena W Holm, Jörgen Borg, Catharina Nygren-de Boussard…

    Citation: Systematic Reviews 2012 1:17

    Content type: Protocol

    Published on:

  35. There is growing evidence of the impact of overweight and obesity on short- and long-term functioning, health and well-being. Internationally, childhood obesity rates continue to rise in some countries (for ex...

    Authors: Clare L Bambra, Frances C Hillier, Helen J Moore and Carolyn D Summerbell

    Citation: Systematic Reviews 2012 1:16

    Content type: Protocol

    Published on:

  36. Systematic reviews have become increasingly critical to informing healthcare policy; however, they remain a time-consuming and labor-intensive activity. The extraction of data from constituent studies comprise...

    Authors: Stanley Ip, Nira Hadar, Sarah Keefe, Christopher Parkin, Ramon Iovin, Ethan M Balk and Joseph Lau

    Citation: Systematic Reviews 2012 1:15

    Content type: Commentary

    Published on:

  37. Several systematic reviews and meta-analyses populate the literature on the effectiveness of laparoscopic surgery for colorectal cancer. The utility of this body of work is unclear. The objective of this study...

    Authors: Guillaume Martel, Suleena Duhaime, Jeffrey S Barkun, Robin P Boushey, Craig R Ramsay and Dean A Fergusson

    Citation: Systematic Reviews 2012 1:14

    Content type: Research

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  38. Infection with the HIV and AIDS are leading causes of morbidity and mortality among women and children worldwide. Prevention of mother-to-child transmission of HIV (PMTCT) programs were developed to protect wo...

    Authors: Frederick LI Morfaw, Lehana Thabane, Lawrence CE Mbuagbaw and Philip N Nana

    Citation: Systematic Reviews 2012 1:13

    Content type: Protocol

    Published on:

  39. The aim of this individual participant data (IPD) meta-analysis is to assess whether the effects of repeat prenatal corticosteroid treatment given to women at risk of preterm birth to benefit their babies are ...

    Authors: Caroline A Crowther, Fariba Aghajafari, Lisa M Askie, Elizabeth V Asztalos, Peter Brocklehurst, Tanya K Bubner, Lex W Doyle, Sourabh Dutta, Thomas J Garite, Debra A Guinn, Mikko Hallman, Mary E Hannah, Pollyanna Hardy, Kimberly Maurel, Premasish Mazumder, Cindy McEvoy…

    Citation: Systematic Reviews 2012 1:12

    Content type: Protocol

    Published on:

  40. Hospital partnerships, mergers and cooperatives are arrangements frequently seen as a means of improving health service delivery. Many of the assumptions used in planning hospital cooperatives are not stated c...

    Authors: Thomas Rotter, Daniela Popa, Beatrice Riley, Tim Ellermann, Ulrike Ryll, Genc Burazeri, Piet Daemen, Guy Peeters and Helmut Brand

    Citation: Systematic Reviews 2012 1:11

    Content type: Protocol

    Published on:

  41. Rapid reviews have emerged as a streamlined approach to synthesizing evidence - typically for informing emergent decisions faced by decision makers in health care settings. Although there is growing use of rap...

    Authors: Sara Khangura, Kristin Konnyu, Rob Cushman, Jeremy Grimshaw and David Moher

    Citation: Systematic Reviews 2012 1:10

    Content type: Methodology

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  42. Challenges exist when searching for diagnostic test accuracy (DTA) studies that include the design of DTA search strategies and selection of appropriate filters. This paper compares the performance of three ME...

    Authors: Rachel Mann and Simon M Gilbody

    Citation: Systematic Reviews 2012 1:9

    Content type: Methodology

    Published on:

  43. A common and potentially life-threatening complication of the treatment of childhood cancer is infection, which frequently presents as fever with neutropenia. The standard management of such episodes is the ex...

    Authors: Robert S Phillips, Alex J Sutton, Richard D Riley, Julia C Chisholm, Susan V Picton and Lesley A Stewart

    Citation: Systematic Reviews 2012 1:8

    Content type: Protocol

    Published on:

  44. Prospective registration of systematic reviews promotes transparency, helps reduce potential for bias and serves to avoid unintended duplication of reviews. Registration offers advantages to many stakeholders ...

    Authors: Lesley Stewart, David Moher and Paul Shekelle

    Citation: Systematic Reviews 2012 1:7

    Content type: Editorial

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  47. Developing and registering protocols may seem like an added burden to systematic review investigators. This paper discusses benefits of protocol registration and debunks common misperceptions on the barriers o...

    Authors: Stephanie M Chang and Jean Slutsky

    Citation: Systematic Reviews 2012 1:4

    Content type: Commentary

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  48. Clinical practice and public health guidelines are important tools for translating research findings into practice with the aim of assisting health practitioners as well as patients and consumers in health beh...

    Authors: Philip Van der Wees, Amir Qaseem, Minna Kaila, Guenter Ollenschlaeger and Richard Rosenfeld

    Citation: Systematic Reviews 2012 1:3

    Content type: Commentary

    Published on:

  49. Following publication of the PRISMA statement, the UK Centre for Reviews and Dissemination (CRD) at the University of York in England began to develop an international prospective register of systematic review...

    Authors: Alison Booth, Mike Clarke, Gordon Dooley, Davina Ghersi, David Moher, Mark Petticrew and Lesley Stewart

    Citation: Systematic Reviews 2012 1:2

    Content type: Methodology

    Published on:

  50. Welcome to a new age in publishing systematic reviews. We hope the launch of Systematic Reviews will resonate with a broad spectrum of readers interested in using them in a variety of ways, such as providing comp...

    Authors: David Moher, Lesley Stewart and Paul Shekelle

    Citation: Systematic Reviews 2012 1:1

    Content type: Editorial

    Published on:

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ISSN: 2046-4053