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  1. Approximately 35 million people world-wide have Alzheimer’s disease and this is projected to nearly double by 2030. Cognitive enhancers, including cholinesterase inhibitors (for example, donepezil, galantamine...

    Authors: Andrea C Tricco, Sondra vanderVaart, Charlene Soobiah, Erin Lillie, Laure Perrier, Maggie H Chen, Brenda Hemmelgarn, Sumit R Majumdar and Sharon E Straus

    Citation: Systematic Reviews 2012 1:31

    Content type: Protocol

    Published on:

  2. High rates of childhood maltreatment have been documented in HIV-positive men and women. In addition, mental disorders are highly prevalent in both HIV-infected individuals and victims of childhood maltreatmen...

    Authors: Georgina Spies, Tracie O Afifi, Sarah L Archibald, Christine Fennema-Notestine, Jitender Sareen and Soraya Seedat

    Citation: Systematic Reviews 2012 1:30

    Content type: Research

    Published on:

  4. This paper argues that the current proliferation of types of systematic reviews creates challenges for the terminology for describing such reviews. Terminology is necessary for planning, describing, appraising...

    Authors: David Gough, James Thomas and Sandy Oliver

    Citation: Systematic Reviews 2012 1:28

    Content type: Commentary

    Published on:

  5. Canada’s diverse society and statutory commitment to multiculturalism means that the synthesis of knowledge related to the health care experiences of immigrants is essential to realize the health potential for...

    Authors: Gina M A Higginbottom, Myfanwy Morgan, Jayantha Dassanayake, Helgi Eyford, Mirande Alexandre, Yvonne Chiu, Joan Forgeron and Deb Kocay

    Citation: Systematic Reviews 2012 1:27

    Content type: Protocol

    Published on:

  6. The objective of this systematic review was to examine the benefits, harms and pharmacokinetic interactions arising from the co-administration of commonly used dietary supplements with cardiovascular drugs. Ma...

    Authors: Salmaan Kanji, Dugald Seely, Fatemeh Yazdi, Jennifer Tetzlaff, Kavita Singh, Alexander Tsertsvadze, Andrea C Tricco, Margaret E Sears, Teik C Ooi, Michele A Turek, Becky Skidmore and Mohammed T Ansari

    Citation: Systematic Reviews 2012 1:26

    Content type: Research

    Published on:

  7. Elderly individuals who have memory problems without significant limitations in activities of daily living are often diagnosed as having mild cognitive impairment (MCI). Some of these individuals progress to d...

    Authors: Andrea C Tricco, Charlene Soobiah, Erin Lillie, Laure Perrier, Maggie H Chen, Brenda Hemmelgarn, Sumit R Majumdar and Sharon E Straus

    Citation: Systematic Reviews 2012 1:25

    Content type: Protocol

    Published on:

  8. Reporting of health research is often inadequate and incomplete. Complete and transparent reporting is imperative to enable readers to assess the validity of research findings for use in healthcare and policy ...

    Authors: Larissa Shamseer, Adrienne Stevens, Becky Skidmore, Lucy Turner, Douglas G Altman, Allison Hirst, John Hoey, Anita Palepu, Iveta Simera, Kenneth Schulz and David Moher

    Citation: Systematic Reviews 2012 1:24

    Content type: Protocol

    Published on:

  9. In April 2005, researchers based at the Medical Research Council Clinical Trials Unit, set out to involve women affected by cervical cancer in a systematic review and meta-analysis of individual patient data t...

    Authors: Claire L Vale, Jayne F Tierney, Nicolette Spera, Andrea Whelan, Alison Nightingale and Bec Hanley

    Citation: Systematic Reviews 2012 1:23

    Content type: Research

    Published on:

  10. There is a significant public health burden associated with substance use in Canada. The early detection and/or treatment of risky substance use has the potential to dramatically improve outcomes for those who...

    Authors: Matthew M Young, Adrienne Stevens, Amy Porath-Waller, Tyler Pirie, Chantelle Garritty, Becky Skidmore, Lucy Turner, Cheryl Arratoon, Nancy Haley, Karen Leslie, Rhoda Reardon, Beth Sproule, Jeremy Grimshaw and David Moher

    Citation: Systematic Reviews 2012 1:22

    Content type: Protocol

    Published on:

  12. Obstructive sleep apnea is a relatively common disorder that can lead to lost productivity and cardiovascular disease. The form of positive airway treatment that should be offered is unclear.

    Authors: Stanley Ip, Carolyn D'Ambrosio, Kamal Patel, Ndidiamaka Obadan, Georgios D Kitsios, Mei Chung and Ethan M Balk

    Citation: Systematic Reviews 2012 1:20

    Content type: Research

    Published on:

  13. Over the past few years, information retrieval has become more and more professionalized, and information specialists are considered full members of a research team conducting systematic reviews. Research grou...

    Authors: Elke Hausner, Siw Waffenschmidt, Thomas Kaiser and Michael Simon

    Citation: Systematic Reviews 2012 1:19

    Content type: Methodology

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  14. In meta-regression, as the number of trials in the analyses decreases, the risk of false positives or false negatives increases. This is partly due to the assumption of normality that may not hold in small sam...

    Authors: Joel J Gagnier, David Moher, Heather Boon, Claire Bombardier and Joseph Beyene

    Citation: Systematic Reviews 2012 1:18

    Content type: Methodology

    Published on:

  15. Mild traumatic brain injury (MTBI) is a major public-health concern and represents 70-90% of all treated traumatic brain injuries. The last best-evidence synthesis, conducted by the WHO Collaborating Centre fo...

    Authors: Carol Cancelliere, J David Cassidy, Pierre Côté, Cesar A Hincapié, Jan Hartvigsen, Linda J Carroll, Connie Marras, Eleanor Boyle, Vicki Kristman, Ryan Hung, Britt-Marie Stålnacke, Peter Rumney, Victor Coronado, Lena W Holm, Jörgen Borg, Catharina Nygren-de Boussard…

    Citation: Systematic Reviews 2012 1:17

    Content type: Protocol

    Published on:

  16. There is growing evidence of the impact of overweight and obesity on short- and long-term functioning, health and well-being. Internationally, childhood obesity rates continue to rise in some countries (for ex...

    Authors: Clare L Bambra, Frances C Hillier, Helen J Moore and Carolyn D Summerbell

    Citation: Systematic Reviews 2012 1:16

    Content type: Protocol

    Published on:

  17. Systematic reviews have become increasingly critical to informing healthcare policy; however, they remain a time-consuming and labor-intensive activity. The extraction of data from constituent studies comprise...

    Authors: Stanley Ip, Nira Hadar, Sarah Keefe, Christopher Parkin, Ramon Iovin, Ethan M Balk and Joseph Lau

    Citation: Systematic Reviews 2012 1:15

    Content type: Commentary

    Published on:

  18. Several systematic reviews and meta-analyses populate the literature on the effectiveness of laparoscopic surgery for colorectal cancer. The utility of this body of work is unclear. The objective of this study...

    Authors: Guillaume Martel, Suleena Duhaime, Jeffrey S Barkun, Robin P Boushey, Craig R Ramsay and Dean A Fergusson

    Citation: Systematic Reviews 2012 1:14

    Content type: Research

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  19. Infection with the HIV and AIDS are leading causes of morbidity and mortality among women and children worldwide. Prevention of mother-to-child transmission of HIV (PMTCT) programs were developed to protect wo...

    Authors: Frederick LI Morfaw, Lehana Thabane, Lawrence CE Mbuagbaw and Philip N Nana

    Citation: Systematic Reviews 2012 1:13

    Content type: Protocol

    Published on:

  20. The aim of this individual participant data (IPD) meta-analysis is to assess whether the effects of repeat prenatal corticosteroid treatment given to women at risk of preterm birth to benefit their babies are ...

    Authors: Caroline A Crowther, Fariba Aghajafari, Lisa M Askie, Elizabeth V Asztalos, Peter Brocklehurst, Tanya K Bubner, Lex W Doyle, Sourabh Dutta, Thomas J Garite, Debra A Guinn, Mikko Hallman, Mary E Hannah, Pollyanna Hardy, Kimberly Maurel, Premasish Mazumder, Cindy McEvoy…

    Citation: Systematic Reviews 2012 1:12

    Content type: Protocol

    Published on:

  21. Hospital partnerships, mergers and cooperatives are arrangements frequently seen as a means of improving health service delivery. Many of the assumptions used in planning hospital cooperatives are not stated c...

    Authors: Thomas Rotter, Daniela Popa, Beatrice Riley, Tim Ellermann, Ulrike Ryll, Genc Burazeri, Piet Daemen, Guy Peeters and Helmut Brand

    Citation: Systematic Reviews 2012 1:11

    Content type: Protocol

    Published on:

  22. Rapid reviews have emerged as a streamlined approach to synthesizing evidence - typically for informing emergent decisions faced by decision makers in health care settings. Although there is growing use of rap...

    Authors: Sara Khangura, Kristin Konnyu, Rob Cushman, Jeremy Grimshaw and David Moher

    Citation: Systematic Reviews 2012 1:10

    Content type: Methodology

    Published on:

  23. Challenges exist when searching for diagnostic test accuracy (DTA) studies that include the design of DTA search strategies and selection of appropriate filters. This paper compares the performance of three ME...

    Authors: Rachel Mann and Simon M Gilbody

    Citation: Systematic Reviews 2012 1:9

    Content type: Methodology

    Published on:

  24. A common and potentially life-threatening complication of the treatment of childhood cancer is infection, which frequently presents as fever with neutropenia. The standard management of such episodes is the ex...

    Authors: Robert S Phillips, Alex J Sutton, Richard D Riley, Julia C Chisholm, Susan V Picton and Lesley A Stewart

    Citation: Systematic Reviews 2012 1:8

    Content type: Protocol

    Published on:

  25. Prospective registration of systematic reviews promotes transparency, helps reduce potential for bias and serves to avoid unintended duplication of reviews. Registration offers advantages to many stakeholders ...

    Authors: Lesley Stewart, David Moher and Paul Shekelle

    Citation: Systematic Reviews 2012 1:7

    Content type: Editorial

    Published on:

  28. Developing and registering protocols may seem like an added burden to systematic review investigators. This paper discusses benefits of protocol registration and debunks common misperceptions on the barriers o...

    Authors: Stephanie M Chang and Jean Slutsky

    Citation: Systematic Reviews 2012 1:4

    Content type: Commentary

    Published on:

  29. Clinical practice and public health guidelines are important tools for translating research findings into practice with the aim of assisting health practitioners as well as patients and consumers in health beh...

    Authors: Philip Van der Wees, Amir Qaseem, Minna Kaila, Guenter Ollenschlaeger and Richard Rosenfeld

    Citation: Systematic Reviews 2012 1:3

    Content type: Commentary

    Published on:

  30. Following publication of the PRISMA statement, the UK Centre for Reviews and Dissemination (CRD) at the University of York in England began to develop an international prospective register of systematic review...

    Authors: Alison Booth, Mike Clarke, Gordon Dooley, Davina Ghersi, David Moher, Mark Petticrew and Lesley Stewart

    Citation: Systematic Reviews 2012 1:2

    Content type: Methodology

    Published on:

  31. Welcome to a new age in publishing systematic reviews. We hope the launch of Systematic Reviews will resonate with a broad spectrum of readers interested in using them in a variety of ways, such as providing comp...

    Authors: David Moher, Lesley Stewart and Paul Shekelle

    Citation: Systematic Reviews 2012 1:1

    Content type: Editorial

    Published on:

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