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  1. Successful chronic care self-management requires adherence to healthy lifestyle behaviors, but many healthcare-based health promotion interventions have resulted in small and unsustainable changes in patient b...

    Authors: Amy E Bodde, Nathan D Shippee, Carl R May, Frances S Mair, Patricia J Erwin, M Hassan Murad and Victor M Montori

    Citation: Systematic Reviews 2013 2:29

    Content type: Protocol

    Published on:

  2. The aim of these reviews is to inform the design and content of interventions to reduce obesity in young children. The behaviors that are associated with obesity/overweight have been studied extensively; howev...

    Authors: Rajalakshmi Lakshman, Veena Mazarello Paes, Kathryn Hesketh, Claire O’Malley, Helen Moore, Ken Ong, Simon Griffin, Esther van Sluijs and Carolyn Summerbell

    Citation: Systematic Reviews 2013 2:28

    Content type: Protocol

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  3. Socioeconomic inequalities in obesity and associated risk factors for obesity are widening throughout developed countries worldwide. Tackling obesity is high on the public health agenda both in the United King...

    Authors: Clare L Bambra, Frances C Hillier, Helen J Moore, Joanne-Marie Cairns-Nagi and Carolyn D Summerbell

    Citation: Systematic Reviews 2013 2:27

    Content type: Protocol

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  4. Ensuring high quality care for persons with diabetes remains a challenge for healthcare systems globally with consistent evidence of suboptimal care and outcomes. There is increasing interest in quality improv...

    Authors: Julia Worswick, S Carolyn Wayne, Rachel Bennett, Michelle Fiander, Alain Mayhew, Michelle C Weir, Katrina J Sullivan and Jeremy M Grimshaw

    Citation: Systematic Reviews 2013 2:26

    Content type: Research

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  5. Pregabalin is used in the treatment of postherpetic neuralgia, diabetic neuropathic pain, partial seizures, anxiety disorders and fibromyalgia. Recognized adverse effects associated with its use include cognit...

    Authors: Joanne M Ho, Andrea C Tricco, Laure Perrier, Maggie Chen, David N Juurlink and Sharon E Straus

    Citation: Systematic Reviews 2013 2:25

    Content type: Protocol

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  6. Meta-analyses are particularly vulnerable to the effects of publication bias. Despite methodologists’ best efforts to locate all evidence for a given topic the most comprehensive searches are likely to miss un...

    Authors: Christine Schmucker, Annette Bluemle, Matthias Briel, Susan Portalupi, Britta Lang, Edith Motschall, Guido Schwarzer, Dirk Bassler, Katharina F Mueller, Erik von Elm and Joerg J Meerpohl

    Citation: Systematic Reviews 2013 2:24

    Content type: Protocol

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  7. Systematic reviews and meta-analyses of pre-clinical studies, in vivo animal experiments in particular, can influence clinical care. Publication bias is one of the major threats of validity in systematic reviews ...

    Authors: Matthias Briel, Katharina F Müller, Joerg J Meerpohl, Erik von Elm, Britta Lang, Edith Motschall, Viktoria Gloy, Francois Lamontagne, Guido Schwarzer and Dirk Bassler

    Citation: Systematic Reviews 2013 2:23

    Content type: Protocol

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  8. Statins are known to reduce cardiovascular morbidity and mortality in primary and secondary prevention studies. Subsequently, a number of nonrandomised studies have shown statins improve clinical outcomes in p...

    Authors: Kwadwo Osei Bonsu, Amudha Kadirvelu and Daniel Diamond Reidpath

    Citation: Systematic Reviews 2013 2:22

    Content type: Protocol

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  9. The arts are powerful, accessible forms of communication that have the potential to impart knowledge by attracting interest and developing meaningful connections. Knowledge translation aims to reduce the ‘evid...

    Authors: Shannon D Scott, Pamela Brett-MacLean, Mandy Archibald and Lisa Hartling

    Citation: Systematic Reviews 2013 2:19

    Content type: Protocol

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  10. Fibromyalgia is associated with substantial socioeconomic loss and, despite considerable research including numerous randomized controlled trials (RCTs) and systematic reviews, there exists uncertainty regardi...

    Authors: Jason W Busse, Shanil Ebrahim, Gaelan Connell, Eric A Coomes, Paul Bruno, Keshena Malik, David Torrance, Trung Ngo, Karin Kirmayr, Daniel Avrahami, John J Riva, Peter Struijs, David Brunarski, Stephen J Burnie, Frances LeBlanc, Ivan A Steenstra…

    Citation: Systematic Reviews 2013 2:18

    Content type: Protocol

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  11. Primary informal caregivers provide a substantial amount of the care and support for persons with Alzheimer’s disease (AD). This review aims to investigate the association between the quality of life (QoL) of ...

    Authors: Afeez Abiola Hazzan, Jenny Ploeg, Harry Shannon, Parminder Raina and Mark Oremus

    Citation: Systematic Reviews 2013 2:17

    Content type: Protocol

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  12. The benefits of aspirin as an anti-platelet agent are well established; however, there has been much debate about the lack of uniformity in the efficacy of aspirin to inhibit platelet function. In some patient...

    Authors: Smriti Raichand, David Moore, Richard D Riley, Marie Lordkipanidzé, Janine Dretzke, Jennifer O’Donnell, Sue Jowett, Sue Bayliss and David A Fitzmaurice

    Citation: Systematic Reviews 2013 2:16

    Content type: Protocol

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  13. Black and Minority Ethnic (BME) groups in receipt of specialist mental health care have reported higher rates of detention under the mental health act, less use of psychological therapies, and more dissatisfac...

    Authors: Kamaldeep Bhui, Rosemarie McCabe, Scott Weich, Swaran Singh, Mark Johnson and Ala Szczepura

    Citation: Systematic Reviews 2013 2:15

    Content type: Protocol

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  14. After a spinal cord injury, quality of life, as well as the determinants of quality of life, has been widely assessed. However, to date, there have been no systematic reviews on the impact of quality improveme...

    Authors: Sarah EP Munce, Laure Perrier, Andrea C Tricco, Sharon E Straus, Michael G Fehlings, Monika Kastner, Eunice Jang, Fiona Webster and Susan B Jaglal

    Citation: Systematic Reviews 2013 2:14

    Content type: Protocol

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  15. Coronary computed tomography angiography has become the foremost noninvasive imaging modality of the coronary arteries and is used as an alternative to the reference standard, conventional coronary angiography...

    Authors: Georg M Schuetz, Peter Schlattmann, Stephan Achenbach, Matthew Budoff, Mario J Garcia, Robert Roehle, Gianluca Pontone, Willem Bob Meijboom, Daniele Andreini, Hatem Alkadhi, Lily Honoris, Nuno Bettencourt, Jörg Hausleiter, Sebastian Leschka, Bernhard L Gerber, Matthijs FL Meijs…

    Citation: Systematic Reviews 2013 2:13

    Content type: Protocol

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  16. One of the effective strategies for reducing the number of maternal deaths is delivery by a skilled birth attendant. Low utilization of skilled birth attendants has been attributed to delay in seeking care, de...

    Authors: Andrea Solnes Miltenburg, Yadira Roggeveen, Marianne van Elteren, Laura Shields, Joske Bunders, Jos van Roosmalen and Jelle Stekelenburg

    Citation: Systematic Reviews 2013 2:11

    Content type: Protocol

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  17. Lung cancer is considered a terminal illness with a five-year survival rate of about 16%. Informed decision-making related to the management of a disease requires accurate prognosis of the disease with or with...

    Authors: Hesborn Wao, Rahul Mhaskar, Ambuj Kumar, Branko Miladinovic and Benjamin Djulbegovic

    Citation: Systematic Reviews 2013 2:10

    Content type: Research

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  18. Improved life expectancy is resulting in increased outpatient treatment of people with chronic physical health conditions and reliance on the provision of informal care in the community. However, informal care...

    Authors: Joanne Woodford, Paul Farrand, David Richards and David J Llewellyn

    Citation: Systematic Reviews 2013 2:9

    Content type: Protocol

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  19. Inflammatory bowel disease is an idiopathic chronic disease that affects around 28 million people worldwide. Symptoms are distressing and have a detrimental effect on patients’ quality of life. A possible link...

    Authors: Mariyana Schoultz, Iain Atherton, Gill Hubbard and Angus JM Watson

    Citation: Systematic Reviews 2013 2:8

    Content type: Protocol

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  20. The Beta-Blockers in Heart Failure Collaborative Group (BB-HF) was formed to obtain and analyze individual patient data from the major randomized controlled trials of beta-blockers in heart failure. Even thoug...

    Authors: Dipak Kotecha, Luis Manzano, Douglas G Altman, Henry Krum, Guliz Erdem, Nicola Williams and Marcus D Flather

    Citation: Systematic Reviews 2013 2:7

    Content type: Methodology

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  21. In 2010, there were approximately 8.8 million incident cases of tuberculosis (TB) worldwide. The treatment of TB is at least six months long and may be complicated by a high pill burden. In addition, TB patien...

    Authors: Mweete D Nglazi, Linda-Gail Bekker, Robin Wood, Gregory D Hussey and Charles S Wiysonge

    Citation: Systematic Reviews 2013 2:6

    Content type: Protocol

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  22. Many reports point to the beneficial effect of male partner involvement in programs for the prevention of mother-to-child-transmission (PMTCT) of HIV in curbing pediatric HIV infections. This paper summarizes ...

    Authors: Frederick Morfaw, Lawrence Mbuagbaw, Lehana Thabane, Clarissa Rodrigues, Ana-Paula Wunderlich, Philip Nana and John Kunda

    Citation: Systematic Reviews 2013 2:5

    Content type: Research

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  23. PROSPERO, an international prospective register of systematic review protocols in health and social care, was launched in February 2011. After one year of operation we describe access and use, explore user exp...

    Authors: Alison Booth, Mike Clarke, Gordon Dooley, Davina Ghersi, David Moher, Mark Petticrew and Lesley Stewart

    Citation: Systematic Reviews 2013 2:4

    Content type: Research

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  24. Problem alcohol use is common among illicit drug users and is associated with adverse health outcomes. It is also an important factor in poor prognosis among drug users with hepatitis C virus (HCV) as it impac...

    Authors: Jan Klimas, Catherine-Anne Field, Walter Cullen, Clodagh SM O’Gorman, Liam G Glynn, Eamon Keenan, Jean Saunders, Gerard Bury and Colum Dunne

    Citation: Systematic Reviews 2013 2:3

    Content type: Research

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  25. Methodological research has found that non-published studies often have different results than those that are published, a phenomenon known as publication bias. When results are not published, or are published...

    Authors: Susan Portalupi, Erik von Elm, Christine Schmucker, Britta Lang, Edith Motschall, Guido Schwarzer, Isabel T Gross, Roberta W Scherer, Dirk Bassler and Joerg J Meerpohl

    Citation: Systematic Reviews 2013 2:2

    Content type: Protocol

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  26. An automated dose dispensing (ADD) service has been implemented in primary healthcare in some European countries. In this service, regularly used medicines are machine-packed into unit-dose bags for each time ...

    Authors: Juha Sinnemäki, Sinikka Sihvo, Jaana Isojärvi, Marja Blom, Marja Airaksinen and Antti Mäntylä

    Citation: Systematic Reviews 2013 2:1

    Content type: Research

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  27. Pulmonary rehabilitation (PR) and self-management (SM) support programmes are effective in the management of patients with chronic obstructive pulmonary disease (COPD), but these interventions are not widely i...

    Authors: Ratna Sohanpal, Richard Hooper, Rachel Hames, Stefan Priebe and Stephanie Taylor

    Citation: Systematic Reviews 2012 1:66

    Content type: Methodology

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  28. Influenza is an acute respiratory illness caused by influenza viruses, which occurs in epidemics worldwide every year. Children are an important target for prevention methods, including vaccination. While evid...

    Authors: Gabriela J Prutsky, Juan Pablo Domecq, Tarig Elraiyah, Zhen Wang, Lisa A Grohskopf, Larry J Prokop, Victor M Montori and Mohammad Hassan Murad

    Citation: Systematic Reviews 2012 1:65

    Content type: Protocol

    Published on:

  29. Low back pain (LBP) is one of the leading causes of disability and has a major socioeconomic impact. Despite a large amount of research in the field, there remains uncertainty about the best treatment approach...

    Authors: Jill A Hayden, Jennifer L Cartwright, Richard D Riley and Maurits W vanTulder

    Citation: Systematic Reviews 2012 1:64

    Content type: Protocol

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  30. In patients undergoing open cardiothoracic and upper abdominal surgery, postoperative pulmonary complications remain an important cause of postoperative morbidity and mortality, impacting upon hospital length ...

    Authors: Christina M Mans, Julie C Reeve, Catherine A Gasparini and Mark R Elkins

    Citation: Systematic Reviews 2012 1:63

    Content type: Protocol

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  31. The aim of this systematic review was to systematically assess the potential patient-relevant benefit (primary aim) and diagnostic and prognostic accuracy (secondary aim) of positron emission tomography (PET) ...

    Authors: Milly A Schröer-Günther, Robert F Wolff, Marie E Westwood, Fülöp J Scheibler, Christoph Schürmann, Brigitta G Baumert, Stefan Sauerland and Jos Kleijnen

    Citation: Systematic Reviews 2012 1:62

    Content type: Systematic review update

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  32. Neuropathic pain can reduce the quality of life and independence of 30% to 50% of patients with diabetes. The comparative effectiveness of analgesics for patients with diabetic neuropathy remains unclear. The ...

    Authors: Marcio L Griebeler, Apostolos Tsapas, Juan P Brito, Zhen Wang, Olivia J Phung, Victor M Montori and M Hassan Murad

    Citation: Systematic Reviews 2012 1:61

    Content type: Protocol

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  33. The Consolidated Standards of Reporting Trials (CONSORT) Statement is intended to facilitate better reporting of randomised clinical trials (RCTs). A systematic review recently published in the Cochrane Librar...

    Authors: Lucy Turner, Larissa Shamseer, Douglas G Altman, Kenneth F Schulz and David Moher

    Citation: Systematic Reviews 2012 1:60

    Content type: Research

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  34. Setting priorities for the prevention and management of heart failure requires an empirical understanding of the pattern of disease burden. We aim to describe the methods for a systematic review of the literat...

    Authors: Derrick A Bennett, Thomas K Eliasz, Anna Forbes, Alastair Kiszely, Rajit Khosla, Tatjana Petrinic, Devarsetty Praveen, Roohi Shrivastava, Du Xin, Anushka Patel, Stephen MacMahon and Kazem Rahimi

    Citation: Systematic Reviews 2012 1:59

    Content type: Protocol

    Published on:

  35. Immigrants from developing and middle-income countries are an emerging priority in HIV prevention in high-income countries. This may be explained in part by accelerating international migration and population ...

    Authors: Tadgh McMahon and Paul R Ward

    Citation: Systematic Reviews 2012 1:56

    Content type: Research

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  36. Studies have reported an impact of central obesity on people’s health. The literature is scarce on the effects of waist circumference (WC) on pulmonary function. Our objective was to review the literature on t...

    Authors: Fernando César Wehrmeister, Ana Maria Baptista Menezes, Ludmila Correa Muniz, Jeovany Martínez-Mesa, Marlos Rodrigues Domingues and Bernardo Lessa Horta

    Citation: Systematic Reviews 2012 1:55

    Content type: Research

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  37. Patients’ expectations of treatment effects may contribute to positive (placebo) and negative (nocebo) outcomes. The effect of patient expectations may be pronounced in subjectively assessed conditions, such a...

    Authors: Frederik Feys, Geertruida E Bekkering, Kavita Singh and Dirk Devroey

    Citation: Systematic Reviews 2012 1:54

    Content type: Protocol

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  38. There is concern that some veterans of armed forces, in particular those with mental health, drug or alcohol problems, experience difficulty returning to a civilian way of life and may subsequently come into c...

    Authors: James Taylor, Tessa Parkes, Sally Haw and Ruth Jepson

    Citation: Systematic Reviews 2012 1:53

    Content type: Protocol

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  39. The enhanced recovery after surgery (ERAS) programme is a multimodal evidence-based approach to surgical care which begins in the preoperative setting and extends through to patient discharge in the postoperat...

    Authors: Lesley Gotlib Conn, Ori D Rotstein, Elisa Greco, Andrea C Tricco, Laure Perrier, Charlene Soobiah and Tony Moloney

    Citation: Systematic Reviews 2012 1:52

    Content type: Protocol

    Published on:

  40. The use of financial incentives and penalties to encourage uptake of healthy behaviors is increasingly seen as a viable intervention in developed countries. Previous reviews of the effectiveness of financial i...

    Authors: Jean Adams, Emma L Giles, Shannon Robalino, Elaine McColl and Falko F Sniehotta

    Citation: Systematic Reviews 2012 1:51

    Content type: Protocol

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  41. Systematic reviewers are increasingly trying to obtain regulatory clinical study reports (CSRs) to correct for publication bias. For instance, our organization, the Institute for Quality and Efficiency in Heal...

    Authors: Beate Wieseler, Natalie McGauran, Michaela F Kerekes and Thomas Kaiser

    Citation: Systematic Reviews 2012 1:50

    Content type: Commentary

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  42. Accessible sexual, reproductive, and mental healthcare services are crucial for adolescent health and wellbeing. It has been reported that school-based healthcare (SBHC) has the potential to improve the availa...

    Authors: Amanda J Mason-Jones, Carolyn Crisp, Mariette Momberg, Joy Koech, Petra De Koker and Cathy Mathews

    Citation: Systematic Reviews 2012 1:49

    Content type: Research

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  43. School-based interventions and campaigns are used to promote health and address a wide variety of public health problems. Schools are considered to be key sites for the implementation of health promotion progr...

    Authors: Mark Pearson, Roy Chilton, Helen B Woods, Katrina Wyatt, Tamsin Ford, Charles Abraham and Rob Anderson

    Citation: Systematic Reviews 2012 1:48

    Content type: Protocol

    Published on:

  44. Diabetes and increased age are known risk factors for physical disability. With the increasing prevalence of diabetes within our aging population, the future burden of disability is expected to increase. To da...

    Authors: Evelyn Wong, Kathryn Backholer, Jessica Harding, Emma Gearon, Christopher Stevenson, Rosanne Freak-Poli and Anna Peeters

    Citation: Systematic Reviews 2012 1:47

    Content type: Protocol

    Published on:

  45. Co-morbid symptoms (for example, chronic pain, depression, anxiety, and fatigue) are particularly common in military fighters returning from the current conflicts, who have experienced physical and/or psycholo...

    Authors: Courtney Lee, Cindy Crawford, Dawn Wallerstedt, Alexandra York, Alaine Duncan, Jennifer Smith, Meredith Sprengel, Richard Welton and Wayne Jonas

    Citation: Systematic Reviews 2012 1:46

    Content type: Research

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  46. Older adults experience activity and participation limitations that are associated with ageing. Activity and participation limitations affect an older adult’s ability to engage in meaningful daily activities a...

    Authors: Kylie Wales, Lindy Clemson, Natasha A Lannin and Ian D Cameron

    Citation: Systematic Reviews 2012 1:45

    Content type: Protocol

    Published on:

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