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  1. Randomised controlled trials (RCTs) of complex interventions in primary health care (PHC) are needed to provide evidence-based programmes to achieve the Declaration of Alma Ata goal of making PHC equitable, ac...

    Authors: Hueiming Liu, Janini Muhunthan, Adina Hayek, Maree Hackett, Tracey-Lea Laba, David Peiris and Stephen Jan

    Citation: Systematic Reviews 2016 5:138

    Content type: Protocol

    Published on:

  2. Many interventions have been implemented to improve maternal health outcomes in sub-Saharan Africa (SSA). Currently, however, systematic information on the effectiveness of these interventions remains scarce. ...

    Authors: Frederick M. Wekesah, Chidozie E. Mbada, Adamson S. Muula, Caroline W. Kabiru, Stella K. Muthuri and Chimaraoke O. Izugbara

    Citation: Systematic Reviews 2016 5:137

    Content type: Research

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  3. With the accumulation of evidence regarding potential harms of cancer screening in recent years, researchers, policy-makers, and the public are becoming more critical of population-based cancer screening. Cons...

    Authors: Brianne Wood, Susan Rogers Van Katwyk, Ziad El-Khatib, Susan McFaul, Monica Taljaard, Erica Wright, Ian D. Graham and Julian Little

    Citation: Systematic Reviews 2016 5:136

    Content type: Protocol

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  4. Chronic obstructive pulmonary disease (COPD) is a respiratory syndrome characterized by progressive, partially reversible airway obstruction and lung hyperinflation. COPD has a substantial burden which is seen...

    Authors: Christopher Plishka, Thomas Rotter, Leigh Kinsman, Mohammed Rashaad Hansia, Adegboyega Lawal, Donna Goodridge, Erika Penz and Darcy D. Marciniuk

    Citation: Systematic Reviews 2016 5:135

    Content type: Protocol

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  5. Diabetic retinopathy is a serious complication of diabetes which, if left untreated, can result in blindness. Population screening among people with diabetes has been shown to be clinically effective; however,...

    Authors: Ella Graham-Rowe, Fabiana Lorencatto, John G. Lawrenson, Jennifer Burr, Jeremy M. Grimshaw, Noah M. Ivers, Tunde Peto, Catey Bunce and Jill J. Francis

    Citation: Systematic Reviews 2016 5:134

    Content type: Protocol

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  6. Mesothelin is a membrane-bound glycoprotein. Although the biologic function of mesothelin is not very clear, researchers have found that it plays a role in the survival, proliferation, and migration of tumor c...

    Authors: Mei Wang, Aihua Li, Guangwen Sun, Lawrence Mbuagbaw, Susan Reid, Peter J. Lovrics and Lehana Thabane

    Citation: Systematic Reviews 2016 5:133

    Content type: Protocol

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  7. To provide evidence synthesis for faster-paced healthcare decision-making, rapid reviews have emerged as a streamlined alternative to standard systematic reviews. In 2012, the Veterans Affairs Evidence-based S...

    Authors: Kim Peterson, Nicole Floyd, Lauren Ferguson, Vivian Christensen and Mark Helfand

    Citation: Systematic Reviews 2016 5:132

    Content type: Research

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  8. Randomised controlled trials guard against selection bias and therefore offer the fairest way of evaluating healthcare interventions such as medicinal products, devices and services. Recruitment to trials can ...

    Authors: Heidi R. Gardner, Cynthia Fraser, Graeme MacLennan and Shaun Treweek

    Citation: Systematic Reviews 2016 5:131

    Content type: Protocol

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  9. Acute myocardial infarction (AMI) is a medical emergency in which sudden occlusion of coronary artery(ies) results in ischemia and necrosis of the cardiac tissues. Reperfusion therapies that aim at reopening t...

    Authors: Chee Yoong Foo, Daniel D. Reidpath and Nathorn Chaiyakunapruk

    Citation: Systematic Reviews 2016 5:130

    Content type: Protocol

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  10. The purpose of this study was to advance a checklist of evaluative criteria designed to assess patient-reported outcome (PRO) measures’ developmental measurement properties and applicability, which can be used...

    Authors: David O. Francis, Melissa L. McPheeters, Meaghan Noud, David F. Penson and Irene D. Feurer

    Citation: Systematic Reviews 2016 5:129

    Content type: Methodology

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  11. Musculoskeletal (MSK) conditions are the most frequently reported chronic conditions and one of the biggest causes of disability in the UK. Given the ageing population and the impact of these problems, the dem...

    Authors: Kate Button, Fiona Morgan, Helen Hodgson, Alison L. Weightman and Steve Jones

    Citation: Systematic Reviews 2016 5:128

    Content type: Protocol

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  12. Cytomegalovirus (CMV) reactivation in critically ill patients is a well-recognized phenomenon with an incidence as high as 71 %. A number of studies have investigated the association between CMV reactivation a...

    Authors: Philippe Lachance, Justin Chen, Robin Featherstone and Wendy Sligl

    Citation: Systematic Reviews 2016 5:127

    Content type: Protocol

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  13. This evidence map describes the volume and focus of Tai Chi research reporting health outcomes. Originally developed as a martial art, Tai Chi is typically taught as a series of slow, low-impact movements that...

    Authors: Michele R. Solloway, Stephanie L. Taylor, Paul G. Shekelle, Isomi M. Miake-Lye, Jessica M. Beroes, Roberta M. Shanman and Susanne Hempel

    Citation: Systematic Reviews 2016 5:126

    Content type: Research

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  14. There is a lack of systematic and comprehensive evaluations whether food intakes lower or increase risk of chronic diseases. In this network meta-analysis of prospective cohort studies, we aim to evaluate the ...

    Authors: Lukas Schwingshackl, Anna Chaimani, Angela Bechthold, Khalid Iqbal, Marta Stelmach-Mardas, Georg Hoffmann, Carolina Schwedhelm, Sabrina Schlesinger and Heiner Boeing

    Citation: Systematic Reviews 2016 5:125

    Content type: Protocol

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  15. The aim of this study is to use a systematic review framework to identify and synthesise the evidence on the use of proton beam therapy (PBT) for the treatment of children with CNS tumours and where possible c...

    Authors: Caroline Main, Madhumita Dandapani, Mark Pritchard, Rachel Dodds, Simon P. Stevens, Nicky Thorp, Roger E. Taylor, Keith Wheatley, Barry Pizer, Matthew Morrall, Robert Phillips, Martin English, Pamela R. Kearns, Sophie Wilne and Jayne S. Wilson

    Citation: Systematic Reviews 2016 5:124

    Content type: Protocol

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  16. Scientific focus on rugby has increased over the recent years, providing evidence of the physical or physiological characteristics and game-specific skills needed in the sport. Identification of tests commonly...

    Authors: Matthew Chiwaridzo, Gillian D. Ferguson and Bouwien C. M. Smits-Engelsman

    Citation: Systematic Reviews 2016 5:122

    Content type: Protocol

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  17. Use of menopausal hormonal therapy (MHT)-containing estrogen and a synthetic progestin is associated with an increased risk of breast cancer. It is unclear if progesterone in combination with estrogen carries ...

    Authors: Noor Asi, Khaled Mohammed, Qusay Haydour, Michael R. Gionfriddo, Oscar L. Morey Vargas, Larry J. Prokop, Stephanie S. Faubion and Mohammad Hassan Murad

    Citation: Systematic Reviews 2016 5:121

    Content type: Research

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  18. Childhood obesity is one of the most serious, global, public health challenges and has adverse health consequences in both the short-and long-term. The purpose of this study is to establish the change in body ...

    Authors: Laura Birch, Rachel Perry, Chris Penfold, Rhona Beynon and Julian Hamilton-Shield

    Citation: Systematic Reviews 2016 5:120

    Content type: Protocol

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  19. Older adults with mild dementia are at an increased risk of falls. Preventing those at risk from falling requires complex interventions involving patient-tailored strength- and balance-challenging exercises, h...

    Authors: Vicky Booth, Rowan Harwood, Victoria Hood, Tahir Masud and Philippa Logan

    Citation: Systematic Reviews 2016 5:119

    Content type: Protocol

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  20. Vascular damage contributes to the high cardiovascular morbidity and mortality in end-stage renal disease (ESRD). Increased aortic stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) is a strong...

    Authors: Rosendo A. Rodriguez, Beverley Shea, Richard Hae and Kevin D. Burns

    Citation: Systematic Reviews 2016 5:118

    Content type: Protocol

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  21. Many patients with kidney failure “crash” onto dialysis or initiate dialysis in an unplanned fashion. There are varying definitions, but essentially, a patient is labeled as having a crash dialysis start if he...

    Authors: Amber O. Molnar, Swapnil Hiremath, Pierre A. Brown and Ayub Akbari

    Citation: Systematic Reviews 2016 5:117

    Content type: Protocol

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  22. Trial registries were established to combat publication bias by creating a comprehensive and unambiguous record of initiated clinical trials. However, the proliferation of registries and registration policies ...

    Authors: Gert van Valkenhoef, Russell F. Loane and Deborah A. Zarin

    Citation: Systematic Reviews 2016 5:116

    Content type: Research

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  23. The NHS needs valid information on the safety and effectiveness of healthcare interventions. Cochrane systematic reviews are an important source of this information. Traditionally, Cochrane has attempted to id...

    Authors: Ian Roberts and Katharine Ker

    Citation: Systematic Reviews 2016 5:115

    Content type: Commentary

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  24. There is increasing pressure to address the social determinants of health (SDoH) and health inequities through the implementation of culturally acceptable interventions particularly in Sub-Saharan Africa (SSA)...

    Authors: Ebenezer Owusu-Addo, Andre M.N. Renzaho, Ajay S. Mahal and Ben J. Smith

    Citation: Systematic Reviews 2016 5:114

    Content type: Protocol

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  25. Studies show that people with dementia do not receive the same amount of analgesia after a hip or pelvic fracture compared to those without cognitive impairment. However, there is no systematic review that sho...

    Authors: S. Kuske, K. Moschinski, S. Andrich, A. Stephan, I. Gnass, E. Sirsch and A. Icks

    Citation: Systematic Reviews 2016 5:113

    Content type: Protocol

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  26. Over the years, family-centered care has evolved as the “gold standard” model for the provision of healthcare services. With the advent of family-centered approach to care comes the inherent need to provide su...

    Authors: Jermaine M. Dambi, Jennifer Jelsma, Tecla Mlambo, Matthew Chiwaridzo, Cathrine Tadyanemhandu, Mildred T. Chikwanha and Lieselotte Corten

    Citation: Systematic Reviews 2016 5:112

    Content type: Protocol

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  27. The prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is increasing. This has spurred the development and publication of clinical practice guidelines (CPGs) for the management of paedia...

    Authors: Dena Zeraatkar, Ahmed Nahari, Pei-Wen Wang, Emily Kearsley, Nicole Falzone, Michael Xu, Laura Banfield, Lehana Thabane and M. Constantine Samaan

    Citation: Systematic Reviews 2016 5:111

    Content type: Protocol

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  28. The diagnosis, management, and treatment for hepatitis C virus (HCV) infection (the “HCV care continuum”) have improved in recent years. People who use drugs (PWUD) have a prevalence of HCV infection from 30 t...

    Authors: Jennifer R. Reed, Ashly E. Jordan, David C. Perlman, Daniel J. Smith and Holly Hagan

    Citation: Systematic Reviews 2016 5:110

    Content type: Protocol

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  29. Infant and young child feeding practices, including breastfeeding and complementary feeding of children under 2 years old, are crucially influenced by parent and family perceptions and experiences. Given the u...

    Authors: Alessandra N. Bazzano, Aiko Kaji, Erica Felker-Kantor, Lisa Saldanha and John Mason

    Citation: Systematic Reviews 2016 5:109

    Content type: Protocol

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  30. Proliferative vitreoretinopathy (PVR) is a known complication of retinal detachment surgery. It has been postulated that the establishment of PVR involves inflammatory and ischaemic processes. Surgical and cli...

    Authors: Rishika Chaudhary, Janine Dretzke, Robert Scott, Ann Logan and Richard Blanch

    Citation: Systematic Reviews 2016 5:107

    Content type: Protocol

    Published on:

  31. People with bipolar disorder (BD) have a mortality gap of up to 20 years compared to the general population. Physical conditions, such as cardiovascular disease (CVD) and cancer, cause the majority of excess d...

    Authors: Frances J. Kay-Lambkin, Louise Thornton, Julia M. Lappin, Tanya Hanstock, Louisa Sylvia, Felice Jacka, Amanda L. Baker, Michal Berk, Phillip B. Mitchell, Robin Callister, Naomi Rogers, Stephanie Webster, Simon Dennis, Christopher Oldmeadow, Andrew MacKinnon, Christopher Doran…

    Citation: Systematic Reviews 2016 5:106

    Content type: Protocol

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  32. Despite its shortcomings, warfarin is still the most commonly prescribed anticoagulant to prevent thromboembolism in children. In adults, numerous studies confirmed the robust relationship between warfarin mai...

    Authors: Masanobu Takeuchi, Tohru Kobayashi, Leonardo R. Brandão and Shinya Ito

    Citation: Systematic Reviews 2016 5:105

    Content type: Protocol

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  33. Cochrane Child Health maintains a register of child-relevant Cochrane systematic reviews (SRs) to provide a comprehensive source of high-quality evidence. However, a large number of SRs are published outside o...

    Authors: Lisa Hartling, Kassi Shave, Denise Thomson, Ricardo M. Fernandes, Aireen Wingert and Katrina Williams

    Citation: Systematic Reviews 2016 5:104

    Content type: Research

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  34. Authors: Paul E. Beaule, Beverley Shea, Hesham Abdelbary, Nadera Ahmadzai, Becky Skidmore, Ranjeeta Mallick, Brian Hutton, Alexandra C. Bunting, Julian Moran, Roxanne Ward and David Moher

    Citation: Systematic Reviews 2016 5:103

    Content type: Erratum

    Published on:

    The original article was published in Systematic Reviews 2015 4:148

  35. Lay health workers (LHWs) are utilised as a channel of delivery in many health interventions. While they have no formal professional training related to their role, they utilise their connections with the targ...

    Authors: Faith Hodgins, Wendy Gnich, Alastair J. Ross, Andrea Sherriff and Heather Worlledge-Andrew

    Citation: Systematic Reviews 2016 5:102

    Content type: Protocol

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  36. Pediatric brain tumors are the most common solid tumors in children. Advances in understanding the hallmarks of cancer biology and novel therapies have led to an increasing number of survivors of childhood bra...

    Authors: Kuan-Wen Wang, Marlie Valencia, Laura Banfield, Ruth Chau, Adam Fleming, Sheila K. Singh, Sarah Burrow, Russell J. de Souza, Lehana Thabane and M. Constantine Samaan

    Citation: Systematic Reviews 2016 5:101

    Content type: Protocol

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  37. Chronic liver disease (CLD) is a major health burden worldwide. Liver cirrhosis, a form of CLD is the fifth most common cause of death in the UK. Acute-on-chronic liver failure (ACLF) is the result of an acute...

    Authors: Nwe Ni Than, Claire L. Tomlinson, Debashis Haldar, Andrew L. King, David Moore and Philip N. Newsome

    Citation: Systematic Reviews 2016 5:100

    Content type: Protocol

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  38. The extracorporeal membrane carbon dioxide removal (ECCO2R) system is primarily designed for the purpose of removing CO2 from the body for patients with potentially reversible severe acute hypercapnic respiratory...

    Authors: Zulian Liu, Rui V. Duarte, Sue Bayliss, George Bramley and Carole Cummins

    Citation: Systematic Reviews 2016 5:98

    Content type: Protocol

    Published on:

  39. The term “health literacy” (HL) was first coined in 1974, and its most common definition is currently defined as a person’s ability to access, understand, evaluate, communicate, and use health information to m...

    Authors: Jessica Shum, Iraj Poureslami, Mary M. Doyle-Waters and J. Mark FitzGerald

    Citation: Systematic Reviews 2016 5:97

    Content type: Protocol

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  40. Hypertension control through pharmacological treatment has led to substantial benefits in the prevention of morbidity and mortality from cardiovascular diseases. However, evidence from a number of studies sugg...

    Authors: Eimear C. Morrissey, Hannah Durand, Robby Nieuwlaat, Tamara Navarro, R. Brian Haynes, Jane C. Walsh and Gerard J. Molloy

    Citation: Systematic Reviews 2016 5:96

    Content type: Protocol

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  41. “Clinical ethics consultation” (CEC) is the provision of consultative services by an individual or team with the aim of helping health professionals, patients, and their families grapple with difficult ethical...

    Authors: Louis Leslie, Rebecca Frances Cherry, Abbas Mulla, Jean Abbott, Kristin Furfari, Jacqueline J. Glover, Benjamin Harnke and Matthew K. Wynia

    Citation: Systematic Reviews 2016 5:95

    Content type: Protocol

    Published on:

  42. Ankle sprains are a significant clinical problem. Researchers have identified a multitude of factors contributing to the presence of recurrent ankle sprains including deficits in balance, postural control, kin...

    Authors: Cassandra Thompson, Siobhan Schabrun, Rick Romero, Andrea Bialocerkowski and Paul Marshall

    Citation: Systematic Reviews 2016 5:94

    Content type: Protocol

    Published on:

  43. The use of non-drug, non-health-service interventions has been proposed as a cost-effective alternative to help those with long-term conditions manage their illness and improve their health and well-being. Int...

    Authors: Kerryn Husk, Kelly Blockley, Rebecca Lovell, Alison Bethel, Dan Bloomfield, Sara Warber, Mark Pearson, Iain Lang, Richard Byng and Ruth Garside

    Citation: Systematic Reviews 2016 5:93

    Content type: Protocol

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  44. Autologous skin grafting is an important modality for wound coverage; however, it can result in donor site morbidity. Epidermal grafting is an emerging option to overcome this challenge. Furthermore, it can be...

    Authors: Muholan Kanapathy, Oliver J Smith, Nadine Hachach-Haram, Nicola Bystrzonowski, Afshin Mosahebi and Toby Richards

    Citation: Systematic Reviews 2016 5:92

    Content type: Protocol

    Published on:

  45. Eczema, synonymous with atopic eczema or atopic dermatitis, is a chronic skin disease that has a similar impact on health-related quality of life as other chronic diseases. The proposed research aims to provid...

    Authors: Tracey Helen Sach, Emma McManus, Christopher Mcmonagle and Nick Levell

    Citation: Systematic Reviews 2016 5:90

    Content type: Protocol

    Published on:

  46. Pulmonary arterial hypertension (PAH) is a rare disease (15 cases per million) that is characterized by widespread loss of the pulmonary microcirculation and elevated pulmonary vascular resistance leading to p...

    Authors: Colin M. Suen, Alex Zhai, Manoj M. Lalu, Christopher Welsh, Brendan M. Levac, Dean Fergusson, Lauralyn McIntyre and Duncan J. Stewart

    Citation: Systematic Reviews 2016 5:89

    Content type: Protocol

    Published on:

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