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  1. The prevalence of knee osteoarthritis (OA)/degenerative joint disease (DJD) is increasing in the USA. Systematic reviews of treatment efficacy and adverse events (AEs) of hyaluronic acid (HA) injections report...

    Authors: Claire E. O’Hanlon, Sydne J. Newberry, Marika Booth, Sean Grant, Aneesa Motala, Margaret A. Maglione, John D. FitzGerald and Paul G. Shekelle

    Citation: Systematic Reviews 2016 5:186

    Content type: Research

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  2. Policymakers and healthcare stakeholders are increasingly seeking evidence to inform the policymaking process, and often use existing or commissioned systematic reviews to inform decisions. However, the method...

    Authors: Chantelle Garritty, Adrienne Stevens, Gerald Gartlehner, Valerie King and Chris Kamel

    Citation: Systematic Reviews 2016 5:184

    Content type: Commentary

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  3. The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect fro...

    Authors: Yu Fu, Monica S. M. Persson, Archan Bhattacharya, Siew-Li Goh, Joanne Stocks, Marienke van Middelkoop, Sita M. A. Bierma-Zeinstra, David Walsh, Michael Doherty and Weiya Zhang

    Citation: Systematic Reviews 2016 5:183

    Content type: Protocol

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  4. Colorectal cancer represents the fourth most common cancer in England and Wales; survival is high for early stage disease but declines sharply with advanced stage. UK figures suggest that cancer survival rates...

    Authors: Ella Mozdiak, Alexander Tsertsvadze, Michael McFarlane, Monika Widlak, Maria Tabuso, Amber Dunlop and Ramesh Arasaradnam

    Citation: Systematic Reviews 2016 5:182

    Content type: Protocol

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  5. Chinese herbal medicine has been used to treat hypertension in China and East Asia since centuries. In this study, we conduct an overview of systematic reviews of Chinese herbal medicine in the treatment of pr...

    Authors: Zhao Xinke, Li Yingdong, Feng Mingxia, Liu Kai, Chen Kaibing, Lu Yuqing, Sun Shaobo, Song Peng and Liu Bin

    Citation: Systematic Reviews 2016 5:180

    Content type: Research

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  6. In 2013, there was a shortage of approximately 7.2 million health workers worldwide, which is larger among family physicians than among specialists. eLearning could provide a potential solution to some of thes...

    Authors: Živa Cotič, Rebecca Rees, Petra A. Wark and Josip Car

    Citation: Systematic Reviews 2016 5:179

    Content type: Protocol

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  7. mLearning is increasingly presented as an attractive novel educational strategy for medical and nursing education. Yet, evidence base for its effectiveness or factors which influence use, success, implementati...

    Authors: Charmaine Krishnasamy, Sik Yin Ong, Yvonne Yock, Issac Lim, Rebecca Rees and Josip Car

    Citation: Systematic Reviews 2016 5:178

    Content type: Protocol

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  8. Cluster randomised trials (CRTs) are a key instrument to evaluate public health interventions, particularly in low- and middle-income countries (LMICs). Fidelity assessment examines study processes to gauge wh...

    Authors: Myriam Cielo Pérez, Nanor Minoyan, Valéry Ridde, Marie-Pierre Sylvestre and Mira Johri

    Citation: Systematic Reviews 2016 5:177

    Content type: Protocol

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  9. Telemedicine applications aim to address variance in clinical outcomes and increase access to specialist expertise. Despite widespread implementation, there is little robust evidence about cost-effectiveness, ...

    Authors: Nicola Mackintosh, Marius Terblanche, Ritesh Maharaj, Andreas Xyrichis, Karen Franklin, Jamie Keddie, Emily Larkins, Anna Maslen, James Skinner, Samuel Newman, Joana Hiew De Sousa Magalhaes and Jane Sandall

    Citation: Systematic Reviews 2016 5:176

    Content type: Research

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  10. Resource and geographic barriers are the commonly cited constraints preventing the uptake of psychological treatment for chronic pain management. For adults, there is some evidence to support the use of inform...

    Authors: Angeline Traynor, Eimear Morrissey, Jonathan Egan and Brian E. McGuire

    Citation: Systematic Reviews 2016 5:175

    Content type: Protocol

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  11. Journal abstracts including those reporting systematic reviews (SR) should contain sufficiently clear and accurate information for adequate comprehension and interpretation. The aim was to compare the quality ...

    Authors: Jean Joel R. Bigna, Lewis N. Um and Jobert Richie N. Nansseu

    Citation: Systematic Reviews 2016 5:174

    Content type: Research

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  12. Failure to successfully implement and sustain change over the long term continues to be a major problem in health and social care. Translating evidence into routine clinical practice is notoriously complex, an...

    Authors: Stephan U. Dombrowski, Pauline Campbell, Helen Frost, Alex Pollock, Julie McLellan, Steve MacGillivray, Anna Gavine, Margaret Maxwell, Ronan O’Carroll, Helen Cheyne, Justin Presseau and Brian Williams

    Citation: Systematic Reviews 2016 5:173

    Content type: Protocol

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  13. Overviews of methods are potentially useful means to increase clarity and enhance collective understanding of specific methods topics that may be characterized by ambiguity, inconsistency, or a lack of compreh...

    Authors: Stephen J. Gentles, Cathy Charles, David B. Nicholas, Jenny Ploeg and K. Ann McKibbon

    Citation: Systematic Reviews 2016 5:172

    Content type: Methodology

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  14. Given limited resources and time constraints, the use of existing systematic reviews (SR) for the development of evidence-based public health recommendations has become increasingly important. Recently, a five...

    Authors: Thomas Harder, Cornelius Remschmidt, Sebastian Haller, Tim Eckmanns and Ole Wichmann

    Citation: Systematic Reviews 2016 5:171

    Content type: Research

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  15. Western publicly funded health care systems increasingly rely on interdisciplinary teams to support primary care delivery and management of chronic conditions. This knowledge synthesis focuses on what is known...

    Authors: W. Dominika Wranik, Jill A. Hayden, Sheri Price, Robin M.N. Parker, Susan M. Haydt, Jeanette M. Edwards, Esther Suter, Alan Katz, Liesl L. Gambold and Adrian R. Levy

    Citation: Systematic Reviews 2016 5:170

    Content type: Protocol

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  16. Distinguishing hydatidiform moles (HMs) from non-molar specimens and the subclassification of HM are important because complete hydatidiform mole (CHM) is associated with an increased risk of gestational troph...

    Authors: Jose Mauro Madi, Antonio Rodrigues Braga, Machline Paim Paganella, Isnard Elman Litvin and Eliana Márcia Da Ros Wendland

    Citation: Systematic Reviews 2016 5:169

    Content type: Protocol

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  17. Approximately half of new invasive breast cancer cases diagnosed each year in the United States occur among women aged 65 years and older. The increasing life expectancy coupled with the attendant rise in brea...

    Authors: Joshua Demb, Isabel Allen and Dejana Braithwaite

    Citation: Systematic Reviews 2016 5:168

    Content type: Protocol

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  18. NHS England’s Five Year Forward View (NHS England, Five Year Forward View, 2014) formally introduced a strategy for new models of care driven by simultaneous pressures to contain costs, improve care and delive...

    Authors: Alison Turner, Abeda Mulla, Andrew Booth, Shiona Aldridge, Sharon Stevens, Fraser Battye and Peter Spilsbury

    Citation: Systematic Reviews 2016 5:167

    Content type: Protocol

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  19. Life-long specialized care is of the utmost importance to safeguard longevity as well as the quality of life in children diagnosed with a chronic condition (CC). Provision of life-long care, however, infers tr...

    Authors: Mariela Acuña Mora, Philip Moons, Carina Sparud-Lundin, Ewa-Lena Bratt and Eva Goossens

    Citation: Systematic Reviews 2016 5:166

    Content type: Protocol

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  20. Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to ide...

    Authors: Monica S. M. Persson, Yu Fu, Archan Bhattacharya, Siew-Li Goh, Marienke van Middelkoop, Sita M. A. Bierma-Zeinstra, David Walsh, Michael Doherty and Weiya Zhang

    Citation: Systematic Reviews 2016 5:165

    Content type: Protocol

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  21. Grey literature includes a range of documents not controlled by commercial publishing organisations. This means that grey literature can be difficult to search and retrieve for evidence synthesis. Much knowled...

    Authors: Jean Adams, Frances C. Hillier-Brown, Helen J. Moore, Amelia A. Lake, Vera Araujo-Soares, Martin White and Carolyn Summerbell

    Citation: Systematic Reviews 2016 5:164

    Content type: Methodology

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  22. Numerous surveys have shown that orthodontic mini implants (OMIs) are underused in clinical practice. To investigate this implementation issue, we conducted a systematic review to (1) identify barriers and fac...

    Authors: Reint Meursinge Reynders, Laura Ronchi, Luisa Ladu, Nicola Di Girolamo, Jan de Lange, Nia Roberts and Sharon Mickan

    Citation: Systematic Reviews 2016 5:163

    Content type: Research

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    The Erratum to this article has been published in Systematic Reviews 2016 5:181

  23. Impetigo, scabies, and fungal skin infections disproportionately affect populations in resource-limited settings. Evidence for standard treatment of skin infections predominantly stem from hospital-based studi...

    Authors: Philippa May, Asha Bowen, Steven Tong, Andrew Steer, Sam Prince, Ross Andrews, Bart Currie and Jonathan Carapetis

    Citation: Systematic Reviews 2016 5:162

    Content type: Protocol

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  24. Osteoporosis is a global high prevalence of chronic metabolic disease with serious disability-adjusted life years losing. Acupuncture is used to treat osteoporosis broadly in China and other countries although...

    Authors: Taipin Guo, Xiao Chen, Xiangnong Wu, Exian Shan, Yaju Jin, Xiantao Tai, Zili Liu, Bowen Zhu, Kai Yuan and Zukun Chen

    Citation: Systematic Reviews 2016 5:161

    Content type: Protocol

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  25. Antiretroviral therapies for human immunodeficiency virus are more effective if infected individuals are diagnosed early, before they have irreversible immunologic damage. A large proportion of patients that a...

    Authors: Benhildah N. Rumbwere Dube, Tom P. Marshall and Ronan P. Ryan

    Citation: Systematic Reviews 2016 5:158

    Content type: Protocol

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  26. Sedatives and analgesics are administered to provide sedation and manage agitation and pain in most critically ill mechanically ventilated patients. Various sedation administration strategies including protoco...

    Authors: Brian Hutton, Lisa D. Burry, Salmaan Kanji, Sangeeta Mehta, Melanie Guenette, Claudio M. Martin, Dean A. Fergusson, Neill K. Adhikari, Ingrid Egerod, David Williamson, Sharon Straus, David Moher, E. Wesley Ely and Louise Rose

    Citation: Systematic Reviews 2016 5:157

    Content type: Protocol

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  27. There is a lack of high-quality meta-analyses and network meta-analyses of immunosuppressive drugs for lupus nephritis. Our objective was to assess the comparative benefits and harms of immunosuppressive drugs...

    Authors: Jasvinder A. Singh, Alomgir Hossain, Ahmed Kotb and George A. Wells

    Citation: Systematic Reviews 2016 5:155

    Content type: Research

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  28. Sedation is an important consideration in the care of the neurocritically ill patient. It provides anxiety and relief, facilitates procedures and nursing tasks, and minimizes intolerance of mechanical ventilat...

    Authors: Alexandre Tran, Henrietta Blinder, Brian Hutton and Shane English

    Citation: Systematic Reviews 2016 5:154

    Content type: Protocol

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  29. Delirium is characterized by acute changes in mental status including inattention, disorganized thinking, and altered level of consciousness, and is highly prevalent in critically ill adults. Delirium has adve...

    Authors: L.D. Burry, B. Hutton, M. Guenette, D. Williamson, S. Mehta, I. Egerod, S. Kanji, N.K. Adhikari, D. Moher, C.M. Martin and L. Rose

    Citation: Systematic Reviews 2016 5:153

    Content type: Protocol

    Published on:

  30. Chronic wounds impose a significant and often underappreciated burden to the individual, the healthcare system and the society as a whole. Preliminary literature search suggests that there are at present no re...

    Authors: Krister Järbrink, Gao Ni, Henrik Sönnergren, Artur Schmidtchen, Caroline Pang, Ram Bajpai and Josip Car

    Citation: Systematic Reviews 2016 5:152

    Content type: Protocol

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  31. Viscoelastic tests, including thromboelastography (TEG) and rotational thromboelastometry (ROTEM), provide a global assessment of haemostatic function at the point of care. The use of a TEG or ROTEM system to ...

    Authors: Kate Elizabeth McCrossin, David Edmund Piers Bramley, Elizabeth Hessian, Evelyn Hutcheon and Georgina Imberger

    Citation: Systematic Reviews 2016 5:151

    Content type: Protocol

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  32. Pressure ulcers are a serious, common, lifelong, and costly secondary complication of spinal cord injury (SCI). Community-dwelling people with a SCI can prevent them with appropriate skin care (i.e. pressure r...

    Authors: Justine Baron, Jillian Swaine, J. Presseau, Arlene Aspinall, Susan Jaglal, Barry White, Dalton Wolfe and Jeremy Grimshaw

    Citation: Systematic Reviews 2016 5:150

    Content type: Protocol

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  33. In term infants, there is evidence that early complementary feeding is a risk factor for childhood obesity. Therefore, timely introduction of complementary feeding during infancy is necessary. The World Health...

    Authors: Karin M. Vissers, Edith J. M. Feskens, Johannes B. van Goudoever and Arieke J. Janse

    Citation: Systematic Reviews 2016 5:149

    Content type: Protocol

    Published on:

  34. This systematic review evaluated St. John’s wort (SJW) for the treatment of Major Depressive Disorder (MDD). The objectives of this review are to (1) evaluate the efficacy and safety of SJW in adults with MDD ...

    Authors: Eric A. Apaydin, Alicia R. Maher, Roberta Shanman, Marika S. Booth, Jeremy N. V. Miles, Melony E. Sorbero and Susanne Hempel

    Citation: Systematic Reviews 2016 5:148

    Content type: Research

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  35. ‘Exercise’ is universally recommended as a core treatment for knee and hip osteoarthritis (OA). However, there are very few head-to-head comparative trials to determine the relative efficacy between different ...

    Authors: Siew-Li Goh, Monica S. M. Persson, Archan Bhattacharya, Michelle Hall, Michael Doherty and Weiya Zhang

    Citation: Systematic Reviews 2016 5:147

    Content type: Protocol

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  36. Chronic conditions are increasingly more common and negatively impact quality of life, disability, morbidity, and mortality. Health coaching has emerged as a possible intervention to help individuals with chro...

    Authors: Kasey R. Boehmer, Suzette Barakat, Sangwoo Ahn, Larry J. Prokop, Patricia J. Erwin and M. Hassan Murad

    Citation: Systematic Reviews 2016 5:146

    Content type: Protocol

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  37. Phantom limb pain (PLP) is characterized by the anatomical shifting of neighbouring somatosensory and motor areas into a deafferented cortical area of the brain contralateral to the amputated limb. It has been...

    Authors: Katleho Limakatso, Lieselotte Corten and Romy Parker

    Citation: Systematic Reviews 2016 5:145

    Content type: Protocol

    Published on:

  38. The parameters of the optic disc and peripapillary retinal nerve fibre layer (pRNFL) in premature children may vary with disease processes that contribute to visual impairment and blindness and so could be use...

    Authors: Alexandra L. Creavin, Cathy E. M. Williams, Kate Tilling, Karen Luyt, Nicholas Timpson and Julian P. T. Higgins

    Citation: Systematic Reviews 2016 5:144

    Content type: Protocol

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  39. The aim of this study is to assess the impact of routine MRI surveillance to detect tumour recurrence in children with no new neurological signs or symptoms compared with alternative follow-up practices, inclu...

    Authors: Caroline Main, Simon P. Stevens, Simon Bailey, Robert Phillips, Barry Pizer, Keith Wheatley, Pamela R. Kearns, Martin English, Sophie Wilne and Jayne S. Wilson

    Citation: Systematic Reviews 2016 5:143

    Content type: Protocol

    Published on:

  40. Oral potentially malignant disorders (OPMDs) are chronic lesions or conditions characterized by a potential for malignant transformation. Apart from being possible pre-cursors to oral cancer, OPMDs themselves ...

    Authors: Zohaib Khan, Sheraz Khan, Lara Christianson, Sara Rehman, Obinna Ekwunife and Florence Samkange-Zeeb

    Citation: Systematic Reviews 2016 5:142

    Content type: Protocol

    Published on:

  41. The rising prevalence of obesity, particularly in childhood, is a global public health emergency. There is some evidence that exposure to non-parental childcare before age 6 years is associated with subsequent...

    Authors: Silvia Costa, Jean Adams, Veronica Phillips and Sara E Benjamin Neelon

    Citation: Systematic Reviews 2016 5:141

    Content type: Protocol

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  42. Meta-research studies investigating methods, systems, and processes designed to improve the efficiency of systematic review workflows can contribute to building an evidence base that can help to increase value...

    Authors: Ian Shemilt, Nada Khan, Sophie Park and James Thomas

    Citation: Systematic Reviews 2016 5:140

    Content type: Research

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  43. With the non-medical use of prescription opioids increasingly becoming a method of abuse in Canada, the number of patients requiring methadone maintenance treatment (MMT) for opioid use disorder has increased ...

    Authors: Laura Zielinski, Meha Bhatt, Rebecca B. Eisen, Stefan Perera, Neera Bhatnagar, James MacKillop, Meir Steiner, Stephanie McDermid Vaz, Lehana Thabane and Zainab Samaan

    Citation: Systematic Reviews 2016 5:139

    Content type: Protocol

    Published on:

  44. Randomised controlled trials (RCTs) of complex interventions in primary health care (PHC) are needed to provide evidence-based programmes to achieve the Declaration of Alma Ata goal of making PHC equitable, ac...

    Authors: Hueiming Liu, Janini Muhunthan, Adina Hayek, Maree Hackett, Tracey-Lea Laba, David Peiris and Stephen Jan

    Citation: Systematic Reviews 2016 5:138

    Content type: Protocol

    Published on:

  45. Many interventions have been implemented to improve maternal health outcomes in sub-Saharan Africa (SSA). Currently, however, systematic information on the effectiveness of these interventions remains scarce. ...

    Authors: Frederick M. Wekesah, Chidozie E. Mbada, Adamson S. Muula, Caroline W. Kabiru, Stella K. Muthuri and Chimaraoke O. Izugbara

    Citation: Systematic Reviews 2016 5:137

    Content type: Research

    Published on:

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